The Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitis

Ates, Dervis; Doner, Hulusi Cem; Kurban, Sevil; Köksal, Hande

doi:10.1080/08820139.2021.1879846

Cited by 7 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We demonstrated elevated CD4 + T lymphocytes secreting IFN-γ and TNF-α cytokines. We also showed diminished CD4 + T lymphocytes producing IL-10 and decreased CD4 + CD25 + CD127 cells (Ates et al, 2021;Emsen et al, 2021;Koksal et al, 2020;Saydam et al, 2020;Ucaryilmaz et al, 2020) resting state and activated state are different (Miyara & Sakaguchi, 2011). CD45RA and CD45RO are used to distinguish the immature Treg cells (CD45RA + Foxp3 low ) from activated memory CD45RA − Foxp3 high Treg cells (Machura et al, 2008).…”

Section: Discussionmentioning

confidence: 77%

“…Recent studies focused on immunopathology have explored the underlying immunological alterations in IGM by investigating the differential lymphocyte subsets and cytokine expressions in immune cells (Ates et al, 2021; Emsen et al, 2021; Koksal et al, 2020; Saydam et al, 2020; Ucaryilmaz et al, 2020). Lymphocytes obtained from patients were stimulated ex vivo with PMA and ionomycin to activate T cells.…”

Section: Discussionmentioning

confidence: 99%

“…Immunological dysfunction has recently been suggested to play a major role in the pathogenesis of IGM (Ates et al, 2021; Emsen et al, 2021; Koksal et al,2020; Saydam et al, 2020; Ucaryilmaz et al, 2020). Although there is no consensus on the treatment of primary IGM, the generally accepted concept is the administration of oral corticosteroids for the diffuse form and surgical excision for the localized form (Asoglu et al, 2005; Erozgen et al, 2010; Karanlik et al, 2014; Lei et al, 2017; Ma et al, 2020; Mizrakli et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ozone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach

Cabıoğlu

Aktaş

Emiroglu

et al. 2022

Cell Biology International

View full text Add to dashboard Cite

Immunological dysfunction has been suggested to play a major role in the pathogenesis of idiopathic granulomatous mastitis (IGM). We recently showed that ozone therapy was effective in patients with steroid-resistant IGM. This study assessed alterations in intracellular cytokine expression patterns in different T-lymphocyte subsets after ozone therapy in refractory IGM. Peripheral blood T lymphocyte subsets (CD8 + , CD4 + , CD4 + CD25 + CD127 − ) were analyzed via flowcytometry for intracellular cytokine expressions IFN-γ, TNF-α, IL-10, and TGF-β before and after completion of 4-month systemic ozone therapy. Ozone therapy significantly increased the CD4 + IFN-γ + (p = 0.032), CD4 + TNF-α + (p = 0.028), and the CD8 + TNF-α + (p = 0.012) T cells. In contrast, significant decreases in CD4 + IL-10 + (p = 0.047) and CD8 + IL-10 + T cells (p = 0.022) and CD4 + CD25 + CD127 −//low Treg cells secreting TGF-β (p = 0.005) were found after ozone therapy. When patients were analyzed according to the response to ozone therapy, patients with a complete remission were more likely to have increased CD3 − CD16 + CD56 + natural killer cells (p = 0.0027) and decreased CD19 + B lymphocytes (p = 0.046) following ozone therapy. Our results suggest that ozone therapy stimulated a T-helper-1 response associated with IFN-γ production and downregulation of TGF-β expression in CD4 + CD25 + CD127 − Treg cells. These alterations in the immune system following ozone therapy can improve wound healing and restore immune dysfunction in patients with refractory IGM.

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ozone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach

Cabıoğlu

Aktaş

Emiroglu

et al. 2022

Cell Biology International

View full text Add to dashboard Cite

show abstract

“…Soluble TREM1 expression has been implicated in idiopathic granulomatous mastitis. It has been proposed that the inhibition of soluble TREM1 may have a significant role in controlling idiopathic granulomatous mastitis (Ates et al, 2022). TREM1 gene was compared in inoculated low somatic scores ewes to control and it was found that TREM1 was among the top differentially expressed genes (Sophie, 2017).…”

Section: Discussionmentioning

confidence: 99%

SNPs in splicing region and miRNA binding region of Bos taurus TREM-1 gene reveals its association with mastitis

Pandupuspitasari,

Khan,

Setiaji

et al. 2023

J. Indonesian Trop. Anim. Agric.

View full text Add to dashboard Cite

Proper splicing is important for the functioning of a gene, and any interruption in splicing causes several deleterious events. Triggering receptors present on myeloid cells, TREM-1, are implicated in inflammation and act as amplifiers by mediating the release of proinflammatory chemokines and cytokines in response to fungal and bacterial infections. In bovines, mastitis is an inflammatory disease in which mammary gland inflammation is generally caused by bacteria. We found rs109937179 and rs208224995 SNPs in the splicing and miRNA binding region of TREM-1 gene in Chinese Holstein cows. The genotype distribution of the alleles for TREM-1 (rs109937179 and rs208224995) gene polymorphisms was investigated in 364 and 320 Chinese Holstein cows, respectively. We found that the GG genotype of the rs109937179 polymorphism and rs208224995 genotype of CA within the TREM-1 gene were associated with an increased risk of mastitis. Importantly, rs109937179 was found in the splicing region of TREM-1, and rs208224995 has a miRNA binding region for bta-miR- 2329-3p in the 3'UTR, which determines its effective roles in gene expression regulation.

show abstract

“…The detected high level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is dedicated to IGM according to a case-control study. In particular, blockade of TREM may be a promising treatment option for resistant or multiple recurrent patients with IGM ( 114 ). In contrast to breast cancer, some preoperative parameters (C-reactive protein, albumin, fibrinogen, fibrinogen/albumin, NLR, etc.)…”

Section: Immune Pathogenesis Of Igmmentioning

confidence: 99%

Immune pathogenesis of idiopathic granulomatous mastitis: from etiology toward therapeutic approaches

Wang,

He,

Liu

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Idiopathic granulomatous mastitis (IGM) is a noncancerous, chronic inflammatory disorder of breast with unknown causes, posing significant challenges to the quality of life due to its high refractoriness and local aggressiveness. The typical symptoms of this disease involve skin redness, a firm and tender breast mass and mastalgia; others may include swelling, fistula, abscess (often without fever), nipple retraction, and peau d’orange appearance. IGM often mimics breast abscesses or malignancies, particularly inflammatory breast cancer, and is characterized by absent standardized treatment options, inconsistent patient response and unknown mechanism. Definite diagnosis of this disease relies on core needle biopsy and histopathological examination. The prevailing etiological theory suggests that IGM is an autoimmune disease, as some patients respond well to steroid treatment. Additionally, the presence of concurrent erythema nodosum or other autoimmune conditions supports the autoimmune nature of the disease. Based on current knowledge, this review aims to elucidate the autoimmune-favored features of IGM and explore its potential etiologies. Furthermore, we discuss the immune-mediated pathogenesis of IGM using existing research and propose immunotherapeutic strategies for managing this condition.

show abstract

The Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitis

Cited by 7 publications

References 33 publications

Ozone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach

Ozone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach

SNPs in splicing region and miRNA binding region of Bos taurus TREM-1 gene reveals its association with mastitis

Immune pathogenesis of idiopathic granulomatous mastitis: from etiology toward therapeutic approaches

Contact Info

Product

Resources

About