The effect of soluble pyrophosphates on dental calculus in adults

W, Zacherl; Pfeiffer, Helmut; Swancar, James R.

doi:10.14219/jada.archive.1985.0441

Cited by 20 publications

(15 citation statements)

References 3 publications

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“…This inhibitory effect was maintained in the group of children who received dental prophylaxis within 6 months of the trial ending. The anticalcu lus effect of ZCT observed in this trial on teenagers is similar to that reported by other workers to be due to use of denti frices containing soluble pyrophosphate salts by adults [Lobene, 1986;Mallatt et al, 1985;Schiff, 1986;Zacherl et al, 1985].…”

supporting

confidence: 90%

In vivo Anticalculus Effect of a Dentifrice Containing 0.5% Zinc Citrate Trihydrate (Short Communication)

et al. 1987

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supporting

confidence: 90%

In vivo Anticalculus Effect of a Dentifrice Containing 0.5% Zinc Citrate Trihydrate (Short Communication)

et al. 1987

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“…Pyrophosphate at various concentrations has been widely used as an anti-calculus agent in dentifrices and mouthrinses. Dentifrices containing pyrophosphate have been confirmed to produce significant calculus reduction (Zacherl et al, 1985). However, pyrophosphate is susceptible to rapid breakdown in the oral cavity by bacterial and host phosphatases and pyrophosphatases.…”

Section: (5):426-441 (2002)mentioning

confidence: 99%

Supragingival Calculus: Formation and Control

Yip

2002

Critical Reviews in Oral Biology & Medicine

151

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Dental calculus is composed of inorganic components and organic matrix. Brushite, dicalcium phosphate dihydrate, octacalcium phosphate, hydroxyapatite, and whitlockite form the mineral part of dental calculus. Salivary proteins selectively adsorb on the tooth surface to form an acquired pellicle. It is followed by the adherence of various oral micro-organisms. Fimbriae, flagella, and some other surface proteins are essential for microbial adherence. Microbial co-aggregation and co-adhesion enable some micro-organisms, which are incapable of adhering, to adhere to the pellicle-coated tooth surface. Once organisms attach to the tooth surface, new genes could be expressed so that mature dental plaque can form and biofilm bacteria assume increased resistance to antimicrobial agents. Supersaturation of saliva and plaque fluid with respect to calcium phosphates is the driving force for plaque mineralization. Both salivary flow rate and plaque pH appear to influence the saturation degree of calcium phosphates. Acidic phospholipids and specific proteolipids present in cell membranes play a key role in microbial mineralization. The roles of crystal growth inhibitors, promoters, and organic acids in calculus formation are discussed. Application of biofilm culture systems in plaque mineralization is concisely reviewed. Anti-calculus agents used-centering on triclosan plus polyvinyl methyl ether/maleic acid copolymer, pyrophosphate plus polyvinyl methyl ether/maleic acid copolymer, and zinc ion-in commercial dentifrices are also discussed in this paper.

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“…The ability of anticalculus dentifrices containing 3.3% pyrophosphate ion to inhibit calculus formation has been demonstrated repeatedly [Lobene and Volpe, 1987;Schiff, 1987;Rosling and Lindhe, 1987;Mallat, 1985;Zacherl et al, 1985]. Because pyrophos phate functions to inhibit calculus formation by inter fering with the formation and growth of crystal nuclei in plaque [McGaughey, 1983], it has the potential of interfering with the natural anticaries mechanism of remineralization.…”

mentioning

confidence: 99%

Evaluation of the Effects of a Pyrophosphate-Fluoride Anticalculus Dentifrice on Remineralization and Fluoride Uptake in situ

Mellberg

Petrou²,

Fletcher³

et al. 1991

Caries Res

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Enamel slabs and thin sections with artificially formed caries lesions were placed in the removable dentures of 15 subjects who brushed them three times daily for 2 weeks with a 1.3% pyrophosphate/1,100 ppm F/1.5% Gantrez dentifrice, a 1,100-ppm F dentifrice without pyrophosphate or Gantrez, or a placebo dentifrice in a double-blind, crossover study. Analysis of the thin sections by quantitative microradiography showed that the pyrophosphate/F dentifrice remineralized the lesions 15.9% (p < 0.05) and the fluoride dentifrice 11.2%, whereas the placebo produced 4.4% demineralization. Fluoride uptake by the enamel slabs was similar for both fluoride dentifrices and significantly greater from the placebo dentifrice (p < 0.05). The findings suggest that the anticaries mechanisms of fluoride include not only the prevention of demineralization, but also the promotion of remineralization.

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The effect of soluble pyrophosphates on dental calculus in adults

Cited by 20 publications

References 3 publications

In vivo Anticalculus Effect of a Dentifrice Containing 0.5% Zinc Citrate Trihydrate (Short Communication)

In vivo Anticalculus Effect of a Dentifrice Containing 0.5% Zinc Citrate Trihydrate (Short Communication)

Supragingival Calculus: Formation and Control

Evaluation of the Effects of a Pyrophosphate-Fluoride Anticalculus Dentifrice on Remineralization and Fluoride Uptake in situ

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