The effect of smoking after surgery for Crohn’s disease: a meta-analysis of observational studies

Reese, George; Nanidis, Theodore; Borysiewicz, Catherine; Yamamoto, Takayuki; Orchard, Timothy R.; Tekkis, Paris

doi:10.1007/s00384-008-0542-9

Cited by 246 publications

(151 citation statements)

References 45 publications

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“…Smoking and perforating disease are reported to be significant risk factors for postoperative recurrence. [8][9][10] We also searched for factors which might have affected the clinical recurrence rates. None of the following factors appeared to affect the incidence of the clinical recurrence: age, gender, duration of CD, smoking habit, previous surgery, and concomitant abscess or fistula at laparotomy.…”

Section: Discussionmentioning

confidence: 99%

The impact of early endoscopic lesions on the clinical course of patients following ileocolonic resection for Crohn’s disease: A 5‐year prospective cohort study

et al. 2013

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Background: Early endoscopic lesions following resection for Crohn's disease (CD) are often observed. Currently, the relationship between this endoscopic observation and subsequent occurrence of CD lesions or recurrence is not understood well, but should be valuable in the context of predicting CD course. This prospective study was to investigate the impact of early endoscopic lesions on future clinical recurrence rates following ileocolonic resection for CD. Methods: Forty patients who had maintained clinical remission, CD activity index (CDAI) <150 with mesalazine during 6 months after ileocolonic resection for CD were included. At 6 months after surgery, ileocolonoscopy was performed, and the endoscopic activity score at the proximal site of the anastomosis was determined according to Rutgeerts. All patients were regularly monitored for 5 years, and clinical recurrence was defined as CDAI ! 150. Corticosteroids, immunosuppressants, or biological agents were not given unless there was clinical recurrence. Results: At 6 months after surgery, the endoscopic scores were i0 or i1 in 27 patients, i2 in seven patients, i3 in four patients, and i4 in two patients. During the following 5 years, the clinical recurrence occurred in three (11%) patients with endoscopic score of i0 or i1, four (57%) patients with i2 score, three (75%) patients with i3 score, and two (100%) patients with i4 score, showing a significant positive correlation (p ¼ 0.001) between the endoscopic severity of the proximal site of the anastomosis at 6 months after surgery and the clinical recurrence rate during the following 5 years. Conclusions: The assessment of endoscopic lesions at the proximal site of the anastomosis appeared to be valuable for predicting subsequent clinical recurrence after ileocolonic resection for CD. Further studies in larger cohorts of patients are warranted to strengthen our findings.

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Section: Discussionmentioning

confidence: 99%

The impact of early endoscopic lesions on the clinical course of patients following ileocolonic resection for Crohn’s disease: A 5‐year prospective cohort study

et al. 2013

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“…W większości badań nie wykazano zwiększenia ich liczby [107][108][109]. Palenie tytoniu zwiększa 2,5-krotnie ryzyko nawrotu choroby po leczeniu operacyjnym [110].…”

Section: Le Ec Cz Ze En Ni Ie E C Ch Hi Ir Ru Ur Rg Gi Ic Cz Zn Ne Eunclassified

Guidelines for the management of Crohn’s disease. Recommendations of the Working Group of the Polish National Consultant in Gastroenterology and the Polish Society of Gastroenterology

Łodyga¹,

Eder²,

Bartnik³

et al. 2012

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“…Patients who continue to smoke following the fi rst operation have an over twofold increased risk of experiencing clinical postoperative recurrence ( 14 ) and need for second intestinal resection ( 13 ).…”

Section: Conflict Of Interestmentioning

confidence: 99%

Editorial: Smoking Cessation for Crohn’s Disease: Clearing the Haze

Kaplan

2016

American Journal of Gastroenterology

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The TABACROHN Study Group conducted a multicenter prospective cohort study, demonstrating that smoking cessation improved the prognosis of Crohn's disease. Patients who continued to smoke were 50% more likely to relapse compared with non-smokers. Smoking cessation reduced the risk of fl aring, regardless of exposure to anti-tumor necrosis factor agents. Despite the evidence that smoking cessation is benefi cial, many patients do not quit smoking after their diagnosis of Crohn's disease. Lack of awareness, physical addiction, and social context of smoking inhibit smoking cessation. In spite of this, comprehensive smoking cessation programs have been shown to be effective and reduce costs.

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The effect of smoking after surgery for Crohn’s disease: a meta-analysis of observational studies

Cited by 246 publications

References 45 publications

The impact of early endoscopic lesions on the clinical course of patients following ileocolonic resection for Crohn’s disease: A 5‐year prospective cohort study

The impact of early endoscopic lesions on the clinical course of patients following ileocolonic resection for Crohn’s disease: A 5‐year prospective cohort study

Guidelines for the management of Crohn’s disease. Recommendations of the Working Group of the Polish National Consultant in Gastroenterology and the Polish Society of Gastroenterology

Editorial: Smoking Cessation for Crohn’s Disease: Clearing the Haze

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