Guidelines for the management of Crohn’s disease. Recommendations of the Working Group of the Polish National Consultant in Gastroenterology and the Polish Society of Gastroenterology

Efficiency and safety of one-year anti-TNF-α treatment in Crohn’s disease: a Polish single-centre experience

“…The guidelines do not regulate when and in which patients anti-TNF-α therapy might be stopped, due to insufficient literature and divergent results [9,10]. The Polish National Insurance Office currently funds IFX therapy in CD patients for up to 2 years and ADA up to 1 year.…”

The diagnostic usefulness of fecal lactoferrin in the assessment of Crohn's disease activity

“…They require a highly qualified personnel and a fully equipped endoscopic laboratory. Despite that, colonoscopy still remains the gold standard for the diagnosis of IBD [1].…”

“…The clinical disease activity was evaluated using Crohn's Disease Activity Index (CDAI), stating that remission was a value less than 150 points, a mild activitybetween 150 and 219 points, moderate activity-between 220 and 450 points, and a severe disease flare-above 450 points [1]. Depending on the localization of the disease, patients underwent a colonoscopy (81 patients) or magnetic resonance enterography (MRE) (89 patients).…”

“…It is assumed that the average time from the first symptoms to the full diagnosis is 4 years. In order to make a final diagnosis, a patient requires a full diagnostic work-up and endoscopic evaluation such as gastroscopy and ileocolonoscopy as well as other imaging studies, which prolongs the time to final diagnosis [1].…”

The Spectrum of Extra-intestinal Manifestation of Crohn's Disease

“…The Montreal Classification by the World Congress of Gastroenterology (WCOG) categorizes CD based on factors including age at diagnosis, disease location, and behavior [2]. CD symptoms are non-specific and vary widely as presentation includes general symptoms such as fever, fatigue, and weight loss, accompanied by intestinal symptoms such as abdominal pain and chronic diarrhea due to inflammation of intestinal mucosa [3,4]. Along with intestinal symptoms, CD also involves extra-intestinal manifestations (EIMs) in 6-36% of patients.…”