1995
DOI: 10.2527/1995.732516x
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The effect of slaframine on salivary output and subacute and acute acidosis in growing beef steers2

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Cited by 37 publications
(24 citation statements)
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“…Therefore, these chemicals may be useful for physiologically manipulating the animal in production situations, such as the feeding of high-grain, low-roughage diets. Although slaframine administration was shown to prevent the decrease in ruminal pH associated with subacute acidosis (Hibbard et al, 1995a), an extended use of slaframine resulted in reduced feed intake and lower animal response (Hibbard et aI., 1995b). Although slaframine administration was shown to prevent the decrease in ruminal pH associated with subacute acidosis (Hibbard et al, 1995a), an extended use of slaframine resulted in reduced feed intake and lower animal response (Hibbard et aI., 1995b).…”
Section: Physiological Modification Of the Animalmentioning
confidence: 99%
“…Therefore, these chemicals may be useful for physiologically manipulating the animal in production situations, such as the feeding of high-grain, low-roughage diets. Although slaframine administration was shown to prevent the decrease in ruminal pH associated with subacute acidosis (Hibbard et al, 1995a), an extended use of slaframine resulted in reduced feed intake and lower animal response (Hibbard et aI., 1995b). Although slaframine administration was shown to prevent the decrease in ruminal pH associated with subacute acidosis (Hibbard et al, 1995a), an extended use of slaframine resulted in reduced feed intake and lower animal response (Hibbard et aI., 1995b).…”
Section: Physiological Modification Of the Animalmentioning
confidence: 99%
“…Some alternatives have been explored including the use of immunizations (Shu et al 1999(Shu et al , 2000, direct fed microbials (Ghorbani et al 2002;Beauchemin et al 2003), and other feed additives (i.e. slaframine, Hibbard et al 1995;malate, Montaño et al 1999). Additionally, many plants, including some forage species in pastures, can produce antimicrobial secondary metabolites that can have beneficial effects on rumen fermentation (Evans and Martin 2000;Benchaar et al 2006;Flythe 2009;Flythe and Kagan 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Under these conditions, rumen papilla are not fully developed with slower absorption of short chain fatty acids (SCFA), increasing their concentration which leads to a decrease in ruminal pH below physiological limits (Kleen et al., 2003). According to Nordlund and Garrett (1994), SARA can be defined as a condition characterized by a rumen pH below 5.8, with an increased total concentration of SCFA, ratio between acetic, propionic and butyric acid that has been shifted towards propionic and butyric acid, and an elevated concentration of lactic acid in the rumen fluid that does not exceed 5–10 mmol/l (Hibbard et al, 1995). The ruminal wall and its papillae herein play an important role and their development has been described (Dirksen et al., 1984).…”
Section: Introductionmentioning
confidence: 99%