The effect of size and surface ligands of iron oxide nanoparticles on blood compatibility

Liu, Tao; Bai, Ru; Zhou, Huige; Wang, Rongqi; Liu, Jing; Zhao, Yuliang; Chen, Chunying

doi:10.1039/c9ra10969b

Cited by 42 publications

(23 citation statements)

References 52 publications

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“…When NPs are used in biomedical applications two very important characteristics must be considered: toxicity and cellular uptake (Rees et al, 2019;Santos-Rasera et al, 2019;Zhang C. et al, 2019). In fact, the biocompatibility of NPs is one of the most critical characteristics of nanoplatforms to be suitable for biomedical purposes (Elmowafy et al, 2019;Liu et al, 2020), and the NPs capability to be internalized by target cells, compared to not-target cells, is a very important goal (Emami et al, 2019;Khan et al, 2019;Khanna et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Sanità

Carrese

Lamberti

2020

Front. Mol. Biosci.

316

147

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The use of nanoparticles (NP) in diagnosis and treatment of many human diseases, including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the uptake efficiency significantly limit their use in clinical practice. The physico-chemical properties of NPs including surface composition, superficial charge, size and shape are considered the key factors that affect the biocompatibility and uptake efficiency of these nanoplatforms. Thanks to the possibility of modifying physico-chemical properties of NPs, it is possible to improve their biocompatibility and uptake efficiency through the functionalization of the NP surface. In this review, we summarize some of the most recent studies in which NP surface modification enhances biocompatibility and uptake. Furthermore, the most used techniques used to assess biocompatibility and uptake are also reported.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Sanità

Carrese

Lamberti

2020

Front. Mol. Biosci.

316

147

View full text Add to dashboard Cite

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“…[35] Hyaluronic acid-and chitosan-modified iron oxide nanoparticles did not affect platelet aggregation up to 1 mg Fe mL −1 , while polyacrylic acid-modified iron oxide nanoparticles did induce significant platelet aggregation at this concentration. [36] We then hypothesized that the observed anti-platelet effect could independently or concomitantly be attributed to (i) the trapping of fibrinogen and/or vWF in the protein corona of PVA-SPIONs which would significantly reduce the availability of these bridging plasma proteins for platelet aggregation, (ii) steric hindrance due to the presence of the SPIONs in the platelet suspensions thus interfering with platelet bridging (i.e., platelet aggregation) following their activation, and (iii) conformational change of fibrinogen in the presence of the SPIONs, thus impairing platelet bridging and subsequent aggregation (Figure 8). Indeed, fibrinogen and vWF have been detected in the adsorbed plasma protein corona of SPIONs [30] and our SPIONs have a high specific surface area (≈150 m 2 g −1 ) to support protein adsorption.…”

Section: Discussionmentioning

confidence: 99%

“…[ 34 ] Other SPION formulations have no influence on platelet functions. [ 35,36 ] Specifically, counterpart 30 nm carbon‐coated iron–carbide nanomagnets do not influence normal platelet aggregation with tested nanomagnet concentrations below 1 mg mL −1 , whether or not they are coated with PEG. [ 35 ] Hyaluronic acid‐ and chitosan‐modified iron oxide nanoparticles did not affect platelet aggregation up to 1 mg Fe mL −1 , while polyacrylic acid‐modified iron oxide nanoparticles did induce significant platelet aggregation at this concentration.…”

Section: Discussionmentioning

confidence: 99%

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Anti‐Platelet Effect Induced by Iron Oxide Nanoparticles: Correlation with Conformational Change in Fibrinogen

Kottana

Maurizi

Schnoor

et al. 2020

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Iron oxide nanoparticles are developed for various biomedical applications, however, there is limited understanding regarding their effects and toxicity on blood components. The particles traveling in circulation inevitably interact with blood cells and plasma proteins and may interfere with hemostasis. Specifically, this study focuses on the influence of superparamagnetic iron oxide nanoparticles (SPIONs) coated with a biocompatible polymer, polyvinyl alcohol (PVA), on platelet function. Here, engineered SPIONs that are functionalized with various PVA coatings to provide these particles with different surface charges and polymer packing are described. These formulations are assessed for any interference with human platelet functions and coagulation, ex vivo. Positively charged SPIONs induce a significant change in platelet GPIIb‐IIIa conformation, indicative of platelet activation at the dose of 500 µg mL−1. Remarkably, engineered PVA(polyvinyl alcohol)‐SPIONs all display a robust dose‐dependent anti‐platelet effect on platelet aggregation, regardless of the PVA charge and molecular weight. After assessing hypotheses involving SPION‐induced steric hindrance in platelet–platelet bridging, as well as protein corona involvement in the antiplatelet effect, the study concludes that the presence of PVA‐SPIONs induces fibrinogen conformational change, which correlates with the observed dose‐dependent anti‐platelet effect.

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“…One example of these side effects was that the agents could not be administered as an intravenous bolus without risking the possible appearance of severe backache. Thus, it is imperative to evaluate biosafety before going to market [ 281 ]. Additionally, the clinically approved SPIONs were unable to differentiate between hepatocellular carcinoma and healthy liver tissue.…”

Section: Imaging Pre-clinical and Clinical Studies Of Core-shell Iron Oxide Agentsmentioning

confidence: 99%

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging.

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The effect of size and surface ligands of iron oxide nanoparticles on blood compatibility

Abstract: Due to the unique physicochemical properties, superparamagnetic iron oxide nanoparticles (SPIONs) have attracted increased attention, which show different effects on red blood cell, plasma, platelet, C3 complement and vascular endothelial cell.

Cited by 42 publications

References 52 publications

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Anti‐Platelet Effect Induced by Iron Oxide Nanoparticles: Correlation with Conformational Change in Fibrinogen

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

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