The effect of simvastatin on remodelling of the alveolar bone following tooth extraction

Introduction Simvastatin, a common cholesterol-lowering drug that inhibits hepatic hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme in the mevalonate pathway, increases expression of the BMP-2 gene and thus promotes bone regeneration. Materials and methods A study was conducted in mandibular third molar sockets to study the efficacy of the drug by implanting it into sockets (experimental group) and observations were made over 3 months to compare the healing with the (control group). Conclusion The results showed faster regeneration of the bone in the simvastatin site using the gray level histogram values.

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“…• Improves trabecular bone density [9,19] • Provides earlier availability of growth factors and BMP [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

Chauhan¹,

Maria²,

Managutti³

2014

J. Maxillofac. Oral Surg.

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“…3 The major limitation to the clinical use of statins for bone regeneration is the lack of an effective carrier for the drug, 4 since the success of in vivo bone formation depends on high local concentrations of statins. 5 Various authors have investigated new methods and carriers for the administration of statins:…”

Section: Introductionmentioning

confidence: 99%

“…• local delivery in methylcellulose gel; 6,7 • local delivery in polylactic acid/polyglycolic acid copolymer; 5 • local delivery in gelatin sponge; 8 and • statins used in combination with calcium sulfate. 9,10 The results have often been encouraging.…”

Section: Introductionmentioning

confidence: 99%

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Lima

Calixto

Anbinder³

2011

Braz. oral res.

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Simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects. Defects of 5 mm were created in 64 rats, divided into four groups: no local treatment (control); treatment with DBBM (DBBM); treatment with a combination of simvastatin solution (2.2 mg/50 µl) and DBBM (DBBMSIM-1); and treatment with simvastatin solution (0.5 mg/50 µl) and DBBM (DBBM-SIM-2). Animals were sacrificed on postoperative day 30 or 60, after which the calvariae were X-rayed and prepared for histomorphometric evaluation. The data were submitted to statistical analysis (p < 0.05). Xrays revealed that, on postoperative day 30, animals treated with a lower dose of simvastatin presented the lowest bone density, whereas on postoperative day 60 the use of simvastatin, regardless of the dose, resulted in lower density than that observed in control and DBBM group samples. Histomorphometric analysis revealed that, on postoperative day 30, both DBBM and DBBMSIM-1 had a negative impact on bone formation. On postoperative day 60, none of the combinations tested impaired bone repair. These results showed that the association between DBBM and simvastatin had a negative impact on bone repair.

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“…PLGA scaffolds are also used to regenerate damaged tissues in regenerative dentistry, together with stem cell-based therapy. In fact, in a work of Hassan, bone formation was obtained with PLGA carriers incorporated with autogenous bone graft [133] or different bone promoting substances such as the bone morphogenetic protein BMP-2 [134] and simvastatin [135]. PLGA was also used for alveolar ridge augmentation through the reconstruction of atrophic sites in association with bone allograft and osteoinductive proteins [136].…”

Section: Polyestersmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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The effect of simvastatin on remodelling of the alveolar bone following tooth extraction

Cited by 102 publications

References 26 publications

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Biodegradable polymers for dental tissue engineering and regeneration

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