The effect of sildenafil, a phosphodiesterase‐5 inhibitor, on acetic acid‐induced colonic inflammation in the rat

İşeri, Sevgin Özlem; Ersoy, Yasemin; Ercan, Feríha; Yüksel, Meral; Atukeren, Pınar; Gümüştaş, Koray; Ali̇can, İnci̇

doi:10.1111/j.1440-1746.2009.05797.x

Cited by 40 publications

(40 citation statements)

References 26 publications

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“…Toxic oxidants can cause damage if the capacity of the endogenous antioxidant enzymes as SOD, catalase and glutathione peroxidase cannot cope with their excess production. Thus, increased oxidative stress and impairment of the antioxidant defenses by the deleterious effect of ROMs contributes to the pathogenesis of colitis (Iseri et al, 2009). It was previously found that oxidative stress and its consequent lipid peroxidation results in increased colonic MDA contents.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Sildenafil, a prototype of PDE5I has shown good effects in experimental colitis by balancing oxidant-antioxidant status and inhibiting ROM production and release of cytokines (Salari-Sharif and Abdollahi, 2010). In a rat model of colitis, Sildenafil prevented lipid peroxidation, cytokine production and neutrophil accumulation, Sildenafil reversed TNF-α and IL-1β in the colitis back to the control value (Iseri et al 2009). A recent study confirmed the anti-inflammatory effect of a PDE5I in a colitis model in rats (Margonis et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the colo-protective effects of tadalafil in an experimental model of ulcerative colitis in rats

Labib¹,

Abdelzaher²,

Shaker³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Ulcerative colitis is a serious premalignant condition with a confusing multifactorial pathogenesis. It should warrant all attention by researchers, for exploration of new prophylactic or therapeutic drugs targeting its pathophysiology. The current study was conducted to study the possible role of tadalafil and its potential actions in ulcerative colitis rat model, induced by acetic acid. Forty eight male Wistar albino rats were classified into 6 groups: control group, acetic acid (AA)-ulcerated group, AA-ulcerated + tadalafil (1 mg/kg/day), AA-ulcerated + tadalafil (5 mg/kg/day), AA-ulcerated + tadalafil (10 mg/kg/day) and AA-ulcerated + sulfasalazine 100 mg/kg/day groups. Tissue malondialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) were determined. Also, caspase-3 gene expression was measured as an indicator of apoptosis. Histopathological examination of the colonic tissue was also done. In addition, serum levels of interleukin (IL)-1β and tumour necrosis factor (TNF)-α were measured. In AA-ulcerated group, there was significant elevation in tissue MDA levels and MPO activity with upregulation of caspase 3 gene expression. Meanwhile, AA caused decreases in the SOD activities. Also, AA induced elevation in the serum IL-1β and TNF-α levels. Pretreatment with tadalafil in doses of 1, 5 and 10 mg/kg/days guarded against changes in these parameters. Its effects were dose-dependent. According to the results, pretreatment with tadalafil in doses of 1, 5 and 10 mg/kg/day exerted dosedependent beneficial effects against AA-induced damage of the colon, possibly by exerting antiinflammatory and antioxidant effects. Also, reduction of apoptosis proved to be one of the contributing protective mechanisms of actions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of the colo-protective effects of tadalafil in an experimental model of ulcerative colitis in rats

Labib¹,

Abdelzaher²,

Shaker³

et al. 2017

Afr. J. Pharm. Pharmacol.

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show abstract

“…[20] Moreover, the beneficial effects of sildenafil have been shown in the balance of oxidation and antioxidation via decreasing oxidative and nitrosative stress in inflammatory events. [9,23,[30][31][32][33][34] However, there is no study in the literature focusing on the effects of sildenafil in remote organ injury induced by severe burn except our previous study focusing on acute lung injury. [9] The purpose of the present study was to evaluate the effects of different dosages of sildenafil in distant organs, such as liver and kidneys, due to severe scald burn injury in rats.…”

Section: Introductionmentioning

confidence: 98%

“…in ischemic colonic anastomoses increased GSH levels and promoted healing of anastomosis. Additionally, Iseri et al [33] found that sildenafil treatment (5 mg/kg/p.o.) decreased MDA and increased GSH levels in tissues and improved the healing of colonic inflammation in rats.…”

mentioning

confidence: 99%

The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

Gökakın

Atabey

Deveci

et al. 2014

Ulus Travma Acil Cerrahi Derg

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“…Recently, several studies have shown that, in addition to treating erectile dysfunction, sildenafil can prevent or decrease tissue injury. Two previous studies demonstrated the beneficial anti-inflammatory effect of SIL on acetic acidinduced acute colitis and bleomycin-induced lung fibrosis models in rats via prevention of lipid peroxidation, oxidant generation, cytokine production and neutrophil accumulation (Iseri et al, 2009;Yildirim al., 2010).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of sildenafil against cysteamine induced duodenal ulcer in Wistar rats

Elberry¹

2013

Afr. J. Pharm. Pharmacol.

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The aim of the current study was to investigate the possible protective effect of sildenafil (SIL) on cysteamine induced peptic ulcer in Wistar rats. Rats were randomly divided into five groups; six animals each. Normal control group; in which animals received an aqueous solution of Tween 80 (1 ml/kg) as a vehicle, two doses orally at an interval of 4 h. SIL group, in which animals received 25 mg/kg SIL orally 30 min before vehicle administration. Cysteamine group; in which duodenal ulceration was induced by two oral doses of cysteamine-HCl (450 mg/kg in 10% aqueous solution) at an interval of 4 h. Cysteamine+omepeazole group; in which animals were pretreated with 20 mg/kg omeprazole orally 30 min before cysteamine. Cysteamine+SIL group; in which animals were pretreated with 25 mg/kg SIL orally, 30 min before cysteamine. Twenty-four hours after the last dose of vehicle or cysteamine, rats were euthanized and the duodena were removed to determine the number of ulcers, ulcer surface area, ulcer score and ulcer index as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS) in tissue homogenates referring to the malondialdehyde, reduced glutathione (GSH) and oxidized glutathione (GSSG). The results of the present study showed that SIL treatment decreased the number of ulcers, the ulcer surface area, the ulcer score and the ulcer index in the cysteamine induced duodenal ulcer. Moreover, SIL ameliorated the biochemical changes that were induced by cysteamine. In conclusion, SIL attenuates experimentally induced peptic ulceration using cysteamine partially through induction of nitrogen oxide (NO) and antioxidant effect which may be useful in the treatment of cystinosis.

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The effect of sildenafil, a phosphodiesterase‐5 inhibitor, on acetic acid‐induced colonic inflammation in the rat

Abstract: Sildenafil citrate administration to rats with acetic acid-induced colitis seems to be beneficial via prevention of lipid peroxidation, oxidant generation, cytokine production and neutrophil accumulation.

Cited by 40 publications

References 26 publications

Evaluation of the colo-protective effects of tadalafil in an experimental model of ulcerative colitis in rats

Evaluation of the colo-protective effects of tadalafil in an experimental model of ulcerative colitis in rats

The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

Protective effect of sildenafil against cysteamine induced duodenal ulcer in Wistar rats

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