Protective effect of sildenafil against cysteamine induced duodenal ulcer in Wistar rats

Elberry, Ahmed A.

doi:10.5897/ajpp2013.3571

Cited by 6 publications

(8 citation statements)

References 34 publications

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“…This was consistent that compound 5 was triterpenoids with five six-membered ring with hydroxymethyl group δH 3.19 (1H, dd, J = 11.5; 5.0 Hz, H-3), olefinic proton δH 5.27 (1H, t, J = 7.5Hz, H-12) ( Table-5). The presence of 30 carbon atoms with 5 methine carbons, 10 methylene carbons, 7 methyl cacbons and 7 quaternary carbons was confirmed by 13 C NMR and DEPT spectra. The difference observed between compounds 4 and 5 was that of methyl group at position 29.…”

Section: Resultsmentioning

confidence: 87%

“…Compound 3 gave a molecular formula of C17H34O2 based on the ESI-MS spectrum, revealing a molecular ion peak at m/z 271,12 [M+H] + . In 1 H NMR spectrum, the resonance signal of methylene group at δH 2.33 (2H, t, J = 7.5 Hz, H-2) directly attached to the carbonyl group corresponding to the carbon signal at δC 33.9 (C -2) in 13 C NMR spectrum and also showed another methylene group, was adjacent to this group at δH 1.64 (2H, quartet, H-3). The presence of a carbonyl group of acid was easily recognized in 13 C NMR spectrum based on resonant signal at δC 179.1 (C-1).…”

Section: Resultsmentioning

confidence: 99%

“…The FT-IR spectra were recorded on an IMPACT-410FT-IR spectrometer (CARL ZEISS JENA). The NMR [ 1 H (500 MHz), 13 C (125 MHz) and DEPT-90 and 135 MHz)] spectra were recorded on an AVANCE spectrometer AV 500 (Brucker, Germany) in the Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam. The chemical shifts were reported in ppm downfield from TMS with J in Hz.…”

Section: Methodsmentioning

confidence: 99%

“…Antiduodenal ulcer activity of n-hexane fraction: Gastric and duodenal antiulcer activity of n-hexane fraction from S. nobilis was evaluated on cysteamine induced gastric and duodenal ulcer models in adult Wistar albino rats with two oral doses of cysteamine (400 mg/kg) at an interval of 4 h[13,14].…”

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confidence: 99%

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Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam

Thi¹,

Duc²,

Thanh³

et al. 2019

Asian J. Chem.

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Five compounds (1-5) were isolated from the leaves of Sanchezia nobilis collected in Nam Dinh province by chromatographic methods. These compounds were identified as: mangiferin (1), β-sitosterol (2), margaric acid (3), ursolic acid (4), oleanolic acid (5). Their structures were elucidated by spectroscopic methods, including mass spectrometry and nuclear magnetic resonance. These compounds were isolated from the leaves of Sanchezia nobilis for the first time. Screening of gastric and duodenal antiulcer effects on indomethacin induced gastric ulcer models showed that n-hexane fraction produced the highest antiulcer activity. Percentage inhibition of gastric ulceration of misoprostol was 22.86 %, while that of n-hexane fraction was 28.57 % (p < 0.05). Evaluation of gastric and duodenal antiulcer effects on acysteamine induced gastric ulcer models showed that this fraction was effective against gastric and duodenal ulcer (83.3 %), improved ulcer damage (54.17 %), significantly reduced the number of mean ulcer and ulcer index (2.00 ± 1.28) but it did not change the area of the ulcer.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam

Thi¹,

Duc²,

Thanh³

et al. 2019

Asian J. Chem.

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“…Gastric and duodenal anti-ulcer activity of ethylacetate fraction from Sanchezia nobilis Hook.F. was evaluated on cysteamine induced gastric and duodenal ulcer models in adult Wistar albino rats with two oral doses of cysteamine (400 mg/kg) at an interval of 4 h. 10,11 Cysteamine hydrochloride has been found to be the most potent agent for inducing duodenal ulcer, and cysteamine induced duodenal ulcer in animals is now used to study the antiulcer activity of drugs. The cysteamine used in experimental studies has been found to concentrate in the duodenum.…”

Section: Evaluation Of Anti-ulcer Activitymentioning

confidence: 99%

Chemical Constituents and Anti-Ulcer Activity of Ethylacetate Extract of the Leaves of Sanchezia nobilis Hook.F.

Duc¹,

Thi²,

Minh³

2019

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Sanchezia nobilis Hook.F. is being paid attention and studied in a lot of different ways. The research of Abu Shuaib Rafshanjani and partners about the evaluation of the safety of Brine shrimp lethality bioassay method on n-hexane and ethylacetate segments, the results showed that both segments were safer than vincristine sulphate. 1 With antimicrobial, antifungal and insecticidal testing by diffusion on agar plates with 15 strains of Gram (+) and Gram (-) bacteria; 6 strains of fungus and insects Tribolium castaleum was not as good as comparison antibiotics. 2 Mohammad javad Paydar and co-worker have tried the antioxidant effect by Oxygen Radical Antioxidant Capacity (ORAC) method, the results were nearly equal to Quercetin and anti-cancer on methanolic segment from Sanchezia speciosa extract on MCF-7, SK-MEL-5, HUVEC giving the best results on CMF-7 cell lines, the anti-cancer effect on Hela cells from the roots of Sanchezia nobilis produced good results by MTT of Nusrat Shaheen and co-worker. 3,4 Research on the antioxidant effect of DPPH and anti-inflammatory by inhibition of albumine denaturation assay method by Bui Thanh Tung and partners gave positive results. 5 Some new claims showing that Sanchezia nobilis Hook.F. contains a number of substance groups such as flavonoids, glycosides, carbohydrates, alkaloids, steroids, phenolic, saponins and tannins. Some specific substances were isolated such as 5 matsutake alcohol compounds, in which the four compounds were first isolated from the Acathanceae family and one was the first isolated from nature, 3-O-arabarabinopyranosyl-(1-6)-β-glucopyranosyl-(1-6)-β-glucopyranosyl-1-octen-3-ol and 6 other compounds from the leaf and root methnol extract, in which 1 substance was first isolated from naturally, 9-O-β-xylopyranosyl-(1→6)-O-βglucopyranosyl-(1→6)-O-β-glucopyranosyltranscinnamyl alcohol, the 4 substances were first isolated from the Acanthaceae family and 3 substances were reported for the first time from Sanchezia by Ahmed and co-worker Bui Thanh Tung and partners also isolated 4 compounds in which 3 compounds were first isolated from Sanchezia speciosa. 6-8 In Vietnam, Sanchezia are found in many localities such as

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PDE5 inhibitors and gastric mucosa: implications for the management of peptic ulcer disease

Jalil¹,

Hassan

Ziyad

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Protective effect of sildenafil against cysteamine induced duodenal ulcer in Wistar rats

Cited by 6 publications

References 34 publications

Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam

Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam

Chemical Constituents and Anti-Ulcer Activity of Ethylacetate Extract of the Leaves of Sanchezia nobilis Hook.F.

PDE5 inhibitors and gastric mucosa: implications for the management of peptic ulcer disease

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