The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway

Qi, Chaoyang; Lin, Yuting; Lin, Dingsheng

doi:10.1080/08941939.2018.1551948

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…VEGF is considered the most potent angiogenic cytokine (Dai & Rabie, 2007; Senger et al, 1996). Qi et al (2020)) demonstrated that Shuxuetong injection enhanced ischemic skin flap survival by promoting angiogenesis via the activation of the VEGF Notch1/Dll4 signaling pathway. Wang et al (2021)) evaluated a myocardial infarction model and demonstrated that tetrandrine upregulated VEGFA levels to promote angiogenesis, consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

“…VEGF is considered the most potent angiogenic cytokine (Dai & Rabie, 2007;Senger et al, 1996). Qi et al (2020) Apoptosis is a programed cell death characterized by specific cellular morphology and biochemical features. Its primary function is to maintain tissue homeostasis by removing redundant, damaged, infected, or unnecessary cells (Sharma et al, 2019).…”

Section: Tetrandrine Promotes Flap Survival By Activating the Pi3k/ak...mentioning

confidence: 99%

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Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway

Wang,

Deng,

Yang

et al. 2023

Phytotherapy Research

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Flaps are mainly used for wound repair. However, postoperative ischemic necrosis of the distal flap is a major problem, which needs to be addressed urgently. We evaluated whether tetrandrine, a compound found in traditional Chinese medicine, can prolong the survival rate of random skin flaps. Thirty‐six rats were randomly divided into control, low‐dose tetrandrine (25 mg/kg/day), and high‐dose tetrandrine (60 mg/kg/day) groups. On postoperative Day 7, the flap survival and average survival area were determined. After the rats were sacrificed, the levels of angiogenesis, apoptosis, and inflammation in the flap tissue were detected with immunology and molecular biology analyses. Tetrandrine increased vascular endothelial growth factor and Bcl‐2 expression, in turn promoting angiogenesis and anti‐apoptotic processes, respectively. Additionally, tetrandrine decreased the expression of Bax, which is associated with the induction of apoptosis, and also decreased inflammation in the flap tissue. Tetrandrine improved the survival rate of random flaps by promoting angiogenesis, inhibiting apoptosis, and reducing inflammation in the flap tissue through the modulation of the PI3K/AKT signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Tetrandrine Promotes Flap Survival By Activating the Pi3k/ak...mentioning

confidence: 99%

Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway

Wang,

Deng,

Yang

et al. 2023

Phytotherapy Research

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“…132 Furthermore, VEGF also has an impact on Notch1/Dll4 signalling pathway and promotes angiogenesis. 133 IL-6 is a vital inflammatory factor for PD patients and over-expressed in human dialysate effluent. 33,73,80,134 At the same time, IL-6 mediated pathway is also related to the expression of VEGF.…”

Section: Signalling Pathways Of Vegf During Peritoneal Neoangiogenesismentioning

confidence: 99%

“…132 Furthermore, VEGF also has an impact on Notch1/Dll4 signalling pathway and promotes angiogenesis. 133…”

Section: Signalling Pathways Of Vegf During Peritoneal Neoangiogenesismentioning

confidence: 99%

Vascular endothelial growth factor-mediated peritoneal neoangiogenesis in peritoneal dialysis

Shi

Cui

et al. 2021

Perit Dial Int

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Peritoneal dialysis (PD) is an important renal replacement therapy for patients with end-stage renal diseases, which is limited by peritoneal neoangiogenesis leading to ultrafiltration failure (UFF). Vascular endothelial growth factor (VEGF) and its receptors are key angiogenic factors involved in almost every step of peritoneal neoangiogenesis. Impaired mesothelial cells are the major sources of VEGF in the peritoneum. The expression of VEGF will be up-regulated in specific pathological conditions in PD patients, such as with non-biocompatible peritoneal dialysate, uremia and inflammation, and so on. Other working cells (i.e. vascular endothelial cells, macrophages and adipocytes) can also stimulate the secretion of VEGF. Meanwhile, hypoxia and activation of complement system further aggravate peritoneal injury and contribute to neoangiogenesis. There are several signalling pathways participating in VEGF-mediated peritoneal neoangiogenesis including tumour growth factor-β, Wnt/β-catenin, Notch and interleukin-6/signal transducer and activator of transcription 3. Moreover, VEGF is highly expressed in dialysate effluent of long-term PD patients and is associated with peritoneal transport function, which supports its role in the alteration of peritoneal structure and function. In this review, we systematically summarize the angiogenic effect of VEGF and evaluate it as a potential target for the prevention of peritoneal neoangiogenesis and UFF. Preservation of the peritoneal membrane using targeted therapy of VEGF-mediated peritoneal neoangiogenesis may increase the longevity of the PD modality for those who require life-long dialysis.

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“…However, when the area of the flap is too large and the aspect ratio exceeds 1.5–2:1, the tissue may become necrotic due to insufficient blood supply, and the clinical failure rate can be as high as 22% . Therefore, it is critical to improve the survival rate of skin flaps used in clinical situations by promoting local angiogenesis and ensuring sufficient blood supply in the flap area. , At present, there have been a wide variety of approaches investigated to promote skin flap survival, such as hyperbaric oxygen therapy, microneedling technique, WALANT technique, stem cell therapy, systemic or local administration, such as local injection of botulinum toxin and intravenous infusion of shuxuetong, , and the use of biomaterial such as cellulose materials, bioactive nanoparticle-based formulations, and hydrogel . However, these strategies have their shortcomings.…”

Section: Introductionmentioning

confidence: 99%

SDF-1 Functionalized Hydrogel Microcarriers for Skin Flap Repair

Liu

Wang

et al. 2022

ACS Biomater. Sci. Eng.

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Critically sized skin flaps used to treat skin defects often suffer from necrosis due to insufficient blood supply. Hence there is an urgent need to improve the survival rate of skin flaps by promoting local angiogenesis. The delivery of growth factor loaded microcarriers have shown promise in enhancing defect repair, however, their rapid clearance from the defect site limits their regenerative potential. Thus, it is critical to develop microcarriers which can promote the sustained release of bioactive factors to effectively stimulate tissue repair. This study aimed to develop a stromal cell-derived factor 1 (SDF-1) loaded microcarrier coated with Matrigel (MC@SDF-1@Mat) to promote skin flap repair. SEM imaging showed that the surface of the microcarrier was coated by a porous Matrigel film. The drug release experiment showed that the Matrigel-coated microcarriers enhanced the sustained release of the model drug methylene blue when compared to uncoated group. MC@SDF-1@Mat significantly promoted the proliferation, migration, and angiogenesis of HUVECs via CCK-8, wound healing assay, and tube formation assay, respectively. Moreover, the murine random skin flap model was further established and treated. It was found that the flap necrosis area in the MC@SDF-1@Mat treated group was significantly reduced. H&E and Masson staining showed the histological structure and collagen organization exhibited a normal phenotype in the MC@SDF-1@Mat treated group. Additionally, CD31 immunohistochemical analysis showed that the MC@SDF-1@Mat treated group exhibited the greatest degree of neovascularization. In conclusion, our SDF-1 functionalized gelatin-based hydrogel microcarrier has potential clinical applications in promoting skin flap repair and drug delivery.

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The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway

Cited by 6 publications

References 23 publications

Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway

Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway

Vascular endothelial growth factor-mediated peritoneal neoangiogenesis in peritoneal dialysis

SDF-1 Functionalized Hydrogel Microcarriers for Skin Flap Repair

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