The effect of Shoseiryuto, a traditional Japanese medicine, on cytochrome P450s, N-acetyltransferase 2 and xanthine oxidase, in extensive or intermediate metabolizers of CYP2D6

Abstract

Our results indicate that TJ-19 at the generally recommended dosage is unlikely to cause pharmacokinetic interaction with co-administered medications primarily dependent on the CYP1A2, CYP2D6, CYP3A, XO, and NAT2 pathways for elimination.

The Effect of <i>Yokukansan</i>, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug–Metabolizing Enzyme Activities in Healthy Male Volunteers

“…The urinary concentrations of three caffeine metabolites [1,7-dimethyluric acid (17U), 1-methyluric acid (1U) and 1-methylxanthine (1X)], DM and three DM metabolites [dextrorphan (DX), 3-methoxymorphinan (MM) and 3-hydroxymorphinan (HM)], 6β-HC and FC were quantified by HPLC according to a previously described method. [23][24][25][26][27] 5-Acetyl-amino-6-formylamino-3-methyluracil (AFMU) was completely converted to 5-acetyl amino-6-amino-3-methyluracil (AAMU) under condition of a pH of 10, and then the AAMU was measured by HPLC according a previously described method. [23][24][25][26][27] Statistical Analysis The levels of CYP1A2, CYP2D6, CYP3A, NAT2 and XO activities were assessed according to the methods of our previous reports, using the following equations.…”

“…[23][24][25][26][27] 5-Acetyl-amino-6-formylamino-3-methyluracil (AFMU) was completely converted to 5-acetyl amino-6-amino-3-methyluracil (AAMU) under condition of a pH of 10, and then the AAMU was measured by HPLC according a previously described method. [23][24][25][26][27] Statistical Analysis The levels of CYP1A2, CYP2D6, CYP3A, NAT2 and XO activities were assessed according to the methods of our previous reports, using the following equations. [23][24][25][26][27] High index values of CYP1A2, NAT2, XO and CYP3A indicate high activity levels.…”

“…[23][24][25][26][27] Statistical Analysis The levels of CYP1A2, CYP2D6, CYP3A, NAT2 and XO activities were assessed according to the methods of our previous reports, using the following equations. [23][24][25][26][27] High index values of CYP1A2, NAT2, XO and CYP3A indicate high activity levels. Conversely, a high index value of DM/DX indicates a low CYP2D6 activity level.…”

“…[23][24][25][26][27] In this study, we attempted to evaluate the effects of YKS on the activity of drug-metabolizing enzymes (CYP1A2, CYP3A, CYP2D6, NAT2, XO) in Japanese healthy volunteers using a similar procedure. [23][24][25][26][27] In addition, we investigated the potential effects of YKS on the activities of CYP2D6, CYP1A2 and NAT2 with these common polymorphisms. 28,29) The primary objective of this clinical study was to verify the potential pharmacokinetic interaction of YKS, which is likely to be used in combination with various medicines that are mainly metabolized by the drug-metabolizing enzymes, such as antidementia, antipsychotic and antidepressants.…”

The Ethical Kampo Formulation Sho-Seiryu-To (TJ-19) Prevents Bleomycin-Induced Pulmonary Fibrosis in Rats

“…[6][7][8] Basic and clinical studies have been conducted to confirm the usefulness of Sho-seiryu-to and TJ-19 (Shoseiryu-to extract granules for ethical use). [9][10][11] Our recent study indicated that TJ-19 drastically attenuated oleic acidinduced lung injury, a representative animal model of acute lung injury with severe hypoxemia and pulmonary edema, at least in part through antioxidative and anti-inflammatory effects. 12) Based on these lines of evidence, TJ-19 may also be effective against inflammatory pulmonary diseases; however, little has been reported on its effects against pulmonary fibrosis.…”