The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion

Криштоп, В. В.; Томилова, И К; Rumyantseva, Tatiana; Mikhaylenko, Elizaveta V; Ávila-Rodriguez, Marco; Mikhaleva, L.M.; Nikolenko, V. N.; Somasundaram, Siva G; Бачурин, С. О.; Aliev, Gjumrakch

doi:10.1007/s12035-020-01930-5

Cited by 15 publications

(5 citation statements)

References 56 publications

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“…На основании дендрограммы выделяли кластеры (последний уровень объединения групп) и субкластеры (предпоследний уровень). Взаимосвязанность изменений первичных данных оценивали при помощи коэффициента корреляции Кендала (τ) [5], последний считали достоверным при p < 0,05. Для статистических исследований применяли программу Statistica 12 («StatSoft», США).…”

Section: Cluster Analysis As An Integrator Of Different Techniques Fo...unclassified

Cluster Analysis as an Integrator of Different Techniques for Assessing the Physical Development of Healthy Adolescents

Semenov

Gayvoronskiy

Krishtop

2023

Astrakhan Medical Journal

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The influence of external factors can significantly deviate the distribution of somatotypes from the indicators of the general population, which makes researchers select the most suitable scheme of so-matotyping from the already known ones or construct their own. Applicants of military universities are a particular case of such samples, formed as a result of a complex of factors, including the work of military medical commissions. The aim was to use cluster analysis to develop an integrative classifica-tion for assessing the physical development of practically healthy adolescents. Materials and meth-ods. The object of the study was 280 applicants (234 boys and 46 girls), who were examined by spe-cialists in the medical commissions of military commissariats and were considered to be practically healthy. Anthropometric data were analyzed: body length, body weight, length of the torso, limbs, girth dimensions of the torso and limbs, as well as body component composition. Hierarchical cluster analysis by the Ward method and Kendall's correlation coefficient were used in the study. Results. By means of cluster analysis of the physical development indicators of the virtually healthy individuals, we identified a significant contribution of body mass index, weight, body length in the formation of three major groups, which we characterized as: the male macrosomatic phenotype, the male mesoso-matic phenotype, and the female phenotype. Based on the proportion of muscle and fat tissue, visceral fat, distal diameter of the forearm as an indicator of bone development, body mass index and thick-ness of the skin-fat fold of the anterior abdominal wall, the following subgroups were identified: male macrosomatic phenotype, with hyperstenic features, male macrosomatic phenotype, with normosthen-ic features, male mesosomatic phenotype with digestive features, male mesosomatic phenotype with mesotonic features, male mesosomatic muscle phenotype, female megalosomic athletic and subathletic phenotype, female stenoplastic phenotype. Conclusion. The used statistical approach allows to change the classical paradigm of searching for a universal methodology of somatotyping, to the creation of algorithms of compilation of well-known schemes of physical development evaluation in the selected population groups.

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Section: Cluster Analysis As An Integrator Of Different Techniques Fo...unclassified

Cluster Analysis as an Integrator of Different Techniques for Assessing the Physical Development of Healthy Adolescents

Semenov

Gayvoronskiy

Krishtop

2023

Astrakhan Medical Journal

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“…This effect was coupled with improved sensory-motor function and memory. Therefore, it suggests that reducing oxidative stress could be an essential mechanism of exercise preconditioning-induced cerebral ischemia tolerance ( Radak et al, 2007 ; Schimidt et al, 2014 ; Sosa et al, 2015 ; Chrishtop et al, 2020 ). The combination therapy of exercise and scalp acupuncture counteracts ischemic brain injury through ROS downregulation, suggesting a potential therapeutic approach in stroke patients ( Li et al, 2020b ).…”

Section: Mechanism Of Exercise Preconditioning Induced Cerebral Ische...mentioning

confidence: 99%

Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke

Zhu¹,

Sun²,

Hu³

et al. 2022

Front. Pharmacol.

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Exercise preconditioning has attracted extensive attention to induce endogenous neuroprotection and has become the hotspot in neurotherapy. The training exercise is given multiple times before cerebral ischemia, effectively inducing ischemic tolerance and alleviating secondary brain damage post-stroke. Compared with other preconditioning methods, the main advantages of exercise include easy clinical operation and being readily accepted by patients. However, the specific mechanism behind exercise preconditioning to ameliorate brain injury is complex. It involves multi-pathway and multi-target regulation, including regulation of inflammatory response, oxidative stress, apoptosis inhibition, and neurogenesis promotion. The current review summarizes the recent studies on the mechanism of neuroprotection induced by exercise, providing the theoretical basis of applying exercise therapy to prevent and treat ischemic stroke. In addition, we highlight the various limitations and future challenges of translational medicine from fundamental study to clinical application.

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“…Dysfunctional protein expression regulation is believed to reinforce cognitive dysfunction after CCH. Various signaling pathways (ferroptosis [ 4 ], autophagy [ 5 ], and oxidative stress [ 6 ]) and cognition-related proteins (MeCP 2 [ 7 ], HIF-1 [ 8 ], hyperphosphorylated tau [ 9 ], and BDNF [ 10 ]) have been implicated in this process. However, despite these diverse potential targets, current therapies have proven ineffective.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion

Yang

Jiang

et al. 2023

Aging

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Chronic cerebral hypoperfusion (CCH)-mediated cognitive impairment is a serious problem worldwide. However, given its complexity, the underlying mechanisms by which CCH induces cognitive dysfunction remain unclear, resulting in a lack of effective treatments. In this study, we aimed to determine whether changes in the expression of RasGRF1, an important protein associated with cognition and synaptic plasticity, underlie the associated impairments in cognition after CCH. We found that RasGRF1 levels markedly decreased following CCH. Through prediction and validation studies, we observed that miRNA-323-3p was upregulated after CCH and could bind to the 3′-untranslated region of Rasgrf1 mRNA and regulate its expression in vitro. Moreover, the inhibition of miRNA-323-3p upregulated Rasgrf1 expression in the hippocampus after CCH, which was reversed by Rasgrf1 siRNA. This suggests that miRNA-323-3p is an important regulator of Rasgrf1. The Morris water maze and Y maze tests showed that miRNA-323-3p inhibition and Rasgrf1 upregulation improved spatial learning and memory, and electrophysiological measurements revealed deficits in long-term potentiation after CCH that were reversed by Rasgrf1 upregulation. Dendritic spine density and mature mushroom spine density were also improved after miRNA-323-3p inhibition and Rasgrf1 upregulation. Furthermore, Rasgrf1 upregulation by miRNA-323-3p inhibition improved dendritic spine density and mature mushroom spine density and ameliorated the deterioration of synapses and postsynaptic density. Overall, RasGRF1 regulation attenuated cognitive impairment, helped maintain structural and functional synaptic plasticity, and prevented synapse deterioration after CCH. These results suggest that Rasgrf1 downregulation by miRNA-323-3p plays an important role in cognitive impairment after CCH. Thus, RasGRF1 and miRNA-323-3p may represent potential therapeutic targets for cognitive impairment after CCH.

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The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion

Cited by 15 publications

References 56 publications

Cluster Analysis as an Integrator of Different Techniques for Assessing the Physical Development of Healthy Adolescents

Cluster Analysis as an Integrator of Different Techniques for Assessing the Physical Development of Healthy Adolescents

Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke

Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion

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