The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles

Abstract

Gold nanomaterials have attracted considerable interest as vehicles for intracellular drug delivery. In our study, we synthesized three different shapes of methylpolyethylene glycol coated-anisotropic gold nanoparticles: stars, rods, and triangles. The cellular internalization of these nanoparticles by RAW264.7 cells was analyzed, providing a parametric evaluation of the effect of shape. The efficiency of cellular uptake of the gold nanoparticles was found to rank in the following order from lowest to highest: stars, rods, and triangles. The possible mechanisms of cellular uptake for the three types of gold nanoparticles were examined, and it was found that different shapes tended to use the various endocytosis pathways in different proportions. Our study, which has demonstrated that shape can modulate the uptake of nanoparticles into RAW264.7 cells and that triangles were the shape with the most efficient cellular uptake, provides useful guidance toward the design of nanomaterials for drug delivery.

Surface‐Active Fluorinated Quantum Dots for Enhanced Cellular Uptake

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Gold Nanotriangles with Crumble Topping and their Influence on Catalysis and Surface‐Enhanced Raman Spectroscopy

“…Xie et al. have coated different anisotropic gold nanoparticles, i. e., nanostars, nanorods and nanotriangles, to investigate the effect of the shape of PEGylated AuNPs . The results show that the efficiency of the cellular uptake is increased in the order stars <rods<triangles .…”

“…have coated different anisotropic gold nanoparticles, i. e., nanostars, nanorods and nanotriangles, to investigate the effect of the shape of PEGylated AuNPs . The results show that the efficiency of the cellular uptake is increased in the order stars <rods<triangles . In general, one can say that gold nanotriangles (AuNTs) entrapped by nonionic or anionic charged biopolymers are preferential components for the non‐toxic cellular uptake.…”

Algunas aplicaciones de la nanofotónica en la biomedicina

“…13(24), 1e-24e, enero-junio 2020 | http://dx.doi.org/10.22201/ceiich.24485691e.2020.24.69618 Elder De la Rosa, Gonzalo Ramírez, Sandeep Panikar, Tanya Camacho, Pedro Salas, Tzarara López-Luke Esparcimiento elástico de luz Como discutimos antes, el realce del esparcimiento de luz incidente sobre una NP de oro ha motivado el estudio de diferentes aproximaciones para el desarrollo de biosensores. En particular la síntesis de NPs terminadas en punta tipo estrella, incrementa el esparcimiento y recorre el plasmón de resonancia hacia el cercano infrarrojo (NIR) favoreciendo las aplicaciones biomédicas al alcanzar la primera ventana biológica (Colleen et al, 2006;Kumar et al, 2007;Xie et al, 2017). Además, presentan una depolarización de la luz 15 veces mayor con respecto a la obtenida por las NPs esféricas, lo que ha permitido implementar la técnica de microscopia de campo obscuro sensible a la polarización, como hemos reportado recientemente (figura 6), (Aaron, et al, 2008).…”