The Effect of Sex Hormones on the Incidence of Experimental Urinary Bladder Tumors in Rats

Kono, Nobuaki; Sasaki, Naosuke; Tanahashi, T; Muraoka, Naoko; Azuma, Cho

doi:10.5980/jpnjurol1928.66.7_409

Cited by 3 publications

(2 citation statements)

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“…Some of these studies have shown that the occurrence of bladder carcinoma induced by chemical carcinogen such as BBN is higher in males than in females [9,10]. It has also been demonstrated that testosterone promotes the occurrence of bladder carcino mas in rats treated with BBN [1,2] and that diethylstilbestrol suppresses it [3,4], The LH-RH agonist also showed a suppressive effect on BBN-induced carcinogenesis in rats [5], All these efforts were aimed at inhibiting testosterone production. In this context, it is important to investigate some treatment strategies to inhibit androgen action in expressed the androgen receptor in the same way as acces sory sex organs do.…”

Section: Discussionmentioning

confidence: 99%

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Promoting Effects and Mechanisms of Action of Androgen in Bladder Carcinogenesis in Male Rats

Imada¹,

Akaza²,

Ami³

et al. 1997

Eur Urol

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Section: Discussionmentioning

confidence: 99%

“…It has been demon strated in various animal models that blocking of produc tion of testosterone inhibits bladder carcinogenesis and that administration of testosterone to the castrated male rats promotes it [1][2][3][4][5]. However, the exact mechanisms by which androgens promote bladder carcinogenesis are not known.…”

Section: Introductionmentioning

confidence: 99%

Promoting Effects and Mechanisms of Action of Androgen in Bladder Carcinogenesis in Male Rats

Imada¹,

Akaza²,

Ami³

et al. 1997

Eur Urol

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1979

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Induction of transitional cell carcinoma of the urinary bladder in rats by feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide

et al. 1978

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After feeding with 0.188% N-[4-(5-nitro-2 furyl)-2-thiazolyl] formamide (FANFT), transitional cell carcinoma of the urinary bladder was induced in all female Wistar rats tested. Histological changes of the urothelium consisted of various degrees of hyperplasia and dysplasia. An infiltrating transitional cell carcinoma first appeared after 8 months. These results are compared with the findings of other authors, and divergencies of the tumour induction rates are discussed with respect to strain, sex and weight of experimental animals as well as concentration and amount of ingested carcinogen. Electron microscopy shows microvillous transformation of the luminal plasma membrane and appearance of a thick fluffy cell coat (glycocalyx). These changes are explained by an altered function of the Golgi complex occurring during malignancy and leading to a loss of the specific discoid vesicles of the urothelial cells.

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The Effect of Sex Hormones on the Incidence of Experimental Urinary Bladder Tumors in Rats

Cited by 3 publications

References 0 publications

Promoting Effects and Mechanisms of Action of Androgen in Bladder Carcinogenesis in Male Rats

Promoting Effects and Mechanisms of Action of Androgen in Bladder Carcinogenesis in Male Rats

Literaturverzeichnis

Induction of transitional cell carcinoma of the urinary bladder in rats by feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide

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