The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men

Parwanto, ML Edy; Suweino, Suweino; Tjahjadi, David; Senjaya, Hardy; Edy, Hosea Jaya; Pakpahan, Alfred

doi:10.5455/ijmsph.2016.17122015293

Cited by 10 publications

(14 citation statements)

References 37 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The other result of my study showed that SHBG levels in normal SHBG phenotype 31.70±13.78 nmol/L, while in variant SHBG phenotype 37.69±16.17 nmol/L. 21 Research conducted by Lapauw et al, also obtained comparable results with this study. 31 The results of another study in Brazil showed that SHBG levels correlated positively with age.…”

Section: Parwanto Mle Int J Res Med Sci 2017 Aug;5(8):3431-3437supporting

confidence: 80%

“…28 The other result of my study in normal SHBG phenotype showed that FT levels 0.065±0.01 nmol/L, while in variant SHBG phenotype 0.064±0.77 nmol/L. 21 The results of this study…”

Section: Resultssupporting

confidence: 49%

“…The other hand showed that insulin levels in men with variant SHBG phenotype was higher than normal SHBG phenotype. 21 This fact reinforces that genetic factors affect to insulin levels in the circulation. This is a limitation of the study because it was not done phenotyping of SHBG.…”

Section: Parwanto Mle Int J Res Med Sci 2017 Aug;5(8):3431-3437mentioning

confidence: 75%

“…23 Current study shows that insulin levels affected by SHBG protein polymorphism in healthy Indonesian men. 21 Recent research shows that the aging process results in an anabolic hormone defect, as resulting in lower physical activity and reduce the quality of nutrition. 24 There is no research data about the correlation between testosterone and SHBG levels with age in healthy Indonesian men.…”

Section: Introductionmentioning

confidence: 99%

“…17 The changes of SHBG levels in the circulation can be caused by metabolic syndrome, overweight/obese and smoking habits. [18][19][20] The other result showed that SHBG protein polymorphisms did not affect to the levels of SHBG, TT and FT. 21 Insulin produced by pancreatic cells and necessary for carbohydrate metabolism in the cells. Furthermore, it has been proven in men that increasing testosterone levels decreases insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The negative correlation between testosterone levels and age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia

Parwanto¹

2017

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Testosterone levels in the circulation determined by production and secretion by Leydig cell in the testes. The action mechanism of testosterone to target cells mediated by sex hormone binding globulin (SHBG). The levels of testosterone and SHBG in circulation determine men's health. The objective in this study to know the relationship between testosterone, SHBG and insulin with age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia.Methods: This study is a cross-sectional study involving 250 healthy Indonesian men residing in the special capital province of Jakarta, Indonesia. Consecutive sampling was done in this study. Testosterone, SHBG and insulin in the serum were measured by immunoradiometric assay (IRMA). Glucose, triglycerides and albumin were measured using a spectrophotometer. Regression analysis was done to know the correlation between testosterone, SHBG and insulin with age.Results: The levels of TT, free testosterone (FT), SHBG and percentage of free testosterone (%FT) in healthy Indonesian men were negatively correlated with age (p<0.05). Free testosterone index (FTI) and insulin are not correlated with age (p>0.05). The levels of SHBG, FT, %FT and FTI were correlated positively with TT (p<0.05), but insulin did not correlate with TT (p>0.05). The %FT and FTI were positively correlated with FT (p<0.05), but SHBG and insulin levels did not correlate with FT (p>0.05). SHBG levels are not correlated with insulin (p>0.05). The rate of decline in TT levels in this study 9.8% per decade, while in SHBG levels 8.19% per decade.Conclusions: The levels of TT, FT, % FT and SHBG in this study were negatively correlated with age, but the FTI and insulin did not correlate with age. The rate of decline in TT levels in this study 9.8% per decade, while in SHBG levels 8.19% per decade.

show abstract

Section: Parwanto Mle Int J Res Med Sci 2017 Aug;5(8):3431-3437supporting

confidence: 80%

“…28 The other result of my study in normal SHBG phenotype showed that FT levels 0.065±0.01 nmol/L, while in variant SHBG phenotype 0.064±0.77 nmol/L. 21 The results of this study…”

Section: Resultssupporting

confidence: 49%

Section: Parwanto Mle Int J Res Med Sci 2017 Aug;5(8):3431-3437mentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The negative correlation between testosterone levels and age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia

Parwanto¹

2017

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation

Goodrich

Dolinoy

et al. 2019

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

Introduction/Purpose Limited studies have examined the association of physical activity with reproductive hormones, DNA methylation, and pubertal status among adolescents. Methods Among 248 boys and 271 girls, we estimated daily physical activity levels based on 7 d of wrist-worn accelerometer data. We used an isotemporal substitution paradigm and sex-stratified regression models to examine the association of physical activity levels with 1) testosterone, cortisol, progesterone, and androstenedione concentrations; 2) DNA methylation of long interspersed nucleotide (LINE-1) repeats and the genes H19, hydroxysteroid (11-Beta) dehydrogenase 2 (HSD11B2), and peroxisome proliferator-activated receptor alpha (PPARA) from blood leukocytes; and 3) Tanner stages, adjusted for age, BMI, and socioeconomic status. Results In boys, substituting 30 min of moderate physical activity for 30 min of sedentary behavior per day was associated with 29% (−49%, 0%) of lower testosterone and 29% (4%, 61%) of higher progesterone. Substituting 30 min of light physical activity for sedentary behavior was associated with 13% (−22%, −2%) of lower progesterone. Among girls, 30 min of additional sedentary behavior was associated with 8% (−15%, 0%) of lower testosterone and 24% (8%, 42%) of higher progesterone concentrations. Substituting 30 min of moderate physical activity for sedentary behavior was associated with 15% (0%, 31%) of higher cortisol, whereas substituting the same amount of light physical activity for sedentary behavior was associated with 22% (−39%, 0%) of lower progesterone. Substituting 30 min of vigorous physical activity for sedentary behavior per day was associated with almost six times higher levels (5.83, 95% confidence interval = 1.79–9.86) of HSD11B2 methylation in boys. Conclusions Accelerometer-measured daily physical activity was associated with reproductive hormones and HSD11B2 DNA methylation, differed by sex and activity intensity levels.

show abstract

Protein pengikat hormon seks: sex hormone binding globulin (SHBG) dan aksi steroid seks

Guyansyah¹,

Parwanto²

2019

J Biomedika Kesehat

View full text Add to dashboard Cite

Jumlah gen pada manusia sekitar 30 000 gen, salah satunya yaitu gen SHBG (sex hormone binding globulin). Telah terbukti bahwa protein merupakan produk gen. Gen yang diekspresikan berarti mengkode sintesis protein. Pada studi ini mempelajari tentang protein sex hormone binding globulin (SHBG) yang merupakan produk gen SHBG. Gen SHBG terletak pada kromosom 17 p 3.1 di setiap sel tubuh kita. Gen SHBG pada hepatosit mengkode protein SHBG, protein tersebut selanjutnya disekresikan ke sistem sirkulasi. Gen SHBG di dalam hepatosit memiliki kesamaan dengan gen androgen binding protein (ABP) di sel Sertoli dalam testis. Jumlah gen pada manusia sekitar 30 000 gen, salah satunya yaitu gen SHBG (sex hormone binding globulin). Telah terbukti bahwa protein merupakan produk gen. Gen yang diekspresikan berarti mengkode sintesis protein. Pada studi ini mempelajari tentang protein sex hormone binding globulin (SHBG) yang merupakan produk gen SHBG. Gen SHBG terletak pada kromosom 17 p 3.1 di setiap sel tubuh kita. Gen SHBG pada hepatosit mengkode protein SHBG, protein tersebut selanjutnya disekresikan ke sistem sirkulasi. Gen SHBG di dalam hepatosit memiliki kesamaan dengan gen androgen binding protein (ABP) di sel Sertoli dalam testis. Dalam sisntesis protein SHBG maupun ABP ada 2 tahap yaitu tahap sintesis prekursor protein dan tahap selanjutnya pematangan prekursor protein di badan Golgi dengan proses glikosilasi. Protein SHBG maupun ABP memiliki funsgi sama yaitu memperantarai aksi hormon steroid seks ke sel sasaran. Ikatan antara SHBG dengan steroid tersebut bersifat reversibel dan berafinitas tinggi untuk mengikat androgen (dehidrotestosteron/DHT, testosteron, 3α-androstenediol), sedangkan ikatan terhadap estrogen aktif maupun estradiol dengan afinitas yang lebih rendah. Aksi steroid seks ke sel sasaran telah terbukti dengan 2 cara yaitu cara pertama dengan berdifusi melewati membran sel sasaran dan cara kedua dengan sistem transduksi sinyal yang diperantarai oleh reseptor SHBG (R-SHBG) pada permukaan sel sasaran. Protein SHBG di dalam sistem sirkulasi memiliki fungsi untuk mengikat hormon steroid seks dan memperantarai aksi hormon tersebut ke sel sasaran di luar testis, sedangkan ABP berfungsi memperantarai aksi hormon steroid seks di dalam testis.

show abstract

The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men

Cited by 10 publications

References 37 publications

The negative correlation between testosterone levels and age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia

The negative correlation between testosterone levels and age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia

Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation

Protein pengikat hormon seks: sex hormone binding globulin (SHBG) dan aksi steroid seks

Contact Info

Product

Resources

About