The Effect of Severe Early Malnutrition on Cellular Growth of Human Brain

Winick, Myron; Rosso, Pedro

doi:10.1203/00006450-196903000-00010

Cited by 289 publications

(65 citation statements)

References 6 publications

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“…This proposition agrees with histochemical studies which showed no alteration in the enzymatic activity of the myenteric neuron s o f rat s whos e mother s wer e submitte d t o a protei n deprivatio n durin g prenatal period 16 . Thes e data , however , ar e oppose d t o othe r observation s carrie d ou t o n rats 18 , humans 19 and guinea pigs 3 when reduction in number and size of the central nervous system neurons after pre and postnatal malnutrition was found .…”

Section: Discussionmentioning

confidence: 87%

“…I t was notice d tha t th e animal s unde r protei n deprivation durin g prenata l an d lactatio n period s presente d greate r quantit y o f larg e an d strongl y basophili c myenteric neurons. This suggest s that neurons have accumulated protei n i n the cytoplasm .KEY WORDS: enteric neurons, myenteric plexus, proteic deprivation, proximal colon, gestation, lactation.Reviewing the available data, it was found that many authors direct their studies to the effec t of undernutrition o n the central nervous system 3,16,18,19 . Fe w were the studies foun d relatin g t o the effects of undernutrition on the peripheral nervous system, and fewer were the studies found concerning …”

mentioning

confidence: 99%

“…Reviewing the available data, it was found that many authors direct their studies to the effec t of undernutrition o n the central nervous system 3,16,18,19 . Fe w were the studies foun d relatin g t o the effects of undernutrition on the peripheral nervous system, and fewer were the studies found concerning …”

mentioning

confidence: 99%

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Effect of maternal protein deprivation on morphological and quantitative aspects of the myenteric plexus neurons of proximal colon in rats

Leite-Mello

Stabille

Miranda-Neto

1997

Arq. Neuro-Psiquiatr.

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-We have studied the morphological an d quantitative aspects of the myenteric plexus neurons of the proximal colon in rats (Rattus norvegicus of Wistar strain) submitted to a protein deprivation during prenatal and lactatio n periods . Twent y pregnan t dam s wer e divide d i n fou r group s labele d accordin g t o th e kin d o f nourishment they were given: Group NN, normal diet; Group DN, low protein diet during prenatal period, and normal diet during lactation period; Group ND, normal diet during prenatal period, and low protein diet during lactation period ; Group DD, low protein die t during prenatal an d lactation periods. Histological analyses wer e developed wit h proxima l colo n segment s usin g th e haematoxyli n an d eosi n stainin g method . Membran e preparations were stained by Giemsa's method. The statistical analysis has demonstrated no significant differenc e among the mean s o f neuron s foun d i n th e fou r studie d groups . I t was notice d tha t th e animal s unde r protei n deprivation durin g prenata l an d lactatio n period s presente d greate r quantit y o f larg e an d strongl y basophili c myenteric neurons. This suggest s that neurons have accumulated protei n i n the cytoplasm .KEY WORDS: enteric neurons, myenteric plexus, proteic deprivation, proximal colon, gestation, lactation.Reviewing the available data, it was found that many authors direct their studies to the effec t of undernutrition o n the central nervous system 3,16,18,19 . Fe w were the studies foun d relatin g t o the effects of undernutrition on the peripheral nervous system, and fewer were the studies found concerning

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Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 99%

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Effect of maternal protein deprivation on morphological and quantitative aspects of the myenteric plexus neurons of proximal colon in rats

Leite-Mello

Stabille

Miranda-Neto

1997

Arq. Neuro-Psiquiatr.

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“…1,2,3 It is one of the most common global health problem, involving hundreds of millions of children in the world, contributing to childhood morbidity, mortality, impaired intellectual development, suboptimal adult work capacity, and increased risk of diseases in adulthood. 1 According to NFHS-4, carried out in 2015-16, 35.7% of children under the age of 5 years in India are underweight, 21% are wasted, 7.5% are severely wasted and 38.4% stunted. 4 These data are even more unacceptably high in Udaipur district of Rajasthan where the toll of Severe Acute Malnutrition has reached to 11.4% as per NFHS 4.…”

Section: Introductionmentioning

confidence: 99%

Impact of malnutrition on head size and development quotient

et al. 2017

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Background: Malnutrition is one of the most common global health problem. It produces notable morphological changes in the brains which damage the intellectual potential and leads to reduced brain size, inferred from measurements of head circumference(HC). Aim is to study the impact of malnutrition on head size and development quotient(DQ) in children suffering with malnutrition.Methods: It is a hospital based study on 120 children including 100 moderates to severely malnourished children and 20 healthy controls aged 6-60 months admitted in malnutrition treatment center. Statistical analysis of head circumference and development quotient was done with severity of malnutrition and with each other.Results: Out of 120 children, 80 were severely malnourished (SAM) and 20 were moderately malnourished (MAM) and 20 age and sex matched controls were taken. Mean age was 19.00±8.54 months. 36.25% of severely malnourished, 5% of moderately malnourished children and none in control had microcephaly (HC<-3SD). Mean DQ was 57.46±14.98, 78.35±6.60 and 94.45±3.96 in SAM, MAM and control children respectively. Statistically significant association was found for head circumference and development quotient with severity of malnutrition and with each other.Conclusions: SAM adversely affects the developing brain of children as evidenced in our study by reduced head size and low DQ scores in children suffering from malnutrition. As seen in this study, prevalence of microcephaly and lower DQ scores increases with severity of malnutrition. Therefore, the study emphasizes the importance of early and timely intervention in such children before the severity of malnutrition increases to an extent of irreversible effects on brain and development.

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“…Evidence that malnutrition in the first 6 months of life may produce permanent subnormal mentality continues to accumulate [67,68].…”

Section: Introductionmentioning

confidence: 99%

Malnutrition with Early Treatment of Phenylketonuria

et al. 1970

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ExtractThirty-two children with phenylketonuria in whom dietary therapy was started prior to 6 months of age are reviewed. Evidence of profound malnutrition during year 1 of life, demonstrated by deficient growth, anemia, hypoproteinemia, roentgenographic bone changes, and various clinical symptoms, was found in three patients. In two of these patients, the malnutrition was quickly corrected; present intelligence levels in these patients are dull normal. The third patient, however, suffered prolonged malnutrition and the present IQ,is only 50. Signs of less severe but prolonged malnutrition were found in 16 patients with phenylketonuria despite apparently adequate diets and adequate levels of phenylalanine in serum. Three of these are retarded, five are borderline, six are in the dull normal intelligence range, and two are normal.In 13 recently diagnosed cases of phenylketonuria, more liberal amounts of phenylalanine and protein were given that resulted in moderate elevation of phenylalanine levels in serum. No evidence of malnutrition was found in these children and present IQ_ tests showed that none was testing retarded or borderline; four were rated as dull normal and nine were normal. Speculation

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The Effect of Severe Early Malnutrition on Cellular Growth of Human Brain

Cited by 289 publications

References 6 publications

Effect of maternal protein deprivation on morphological and quantitative aspects of the myenteric plexus neurons of proximal colon in rats

Effect of maternal protein deprivation on morphological and quantitative aspects of the myenteric plexus neurons of proximal colon in rats

Impact of malnutrition on head size and development quotient

Malnutrition with Early Treatment of Phenylketonuria

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