The effect of seeding on the phase separation phenomenon in a solidifying molten drop

Abouzeid, Abdel-Zaher M.; Petersen, Sandra; Ulrich, Joachim

doi:10.1016/j.apt.2014.10.013

Cited by 4 publications

(15 citation statements)

References 5 publications

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“…Differently‐coated cooling surfaces result in the production of tablet batches with different geometries …”

Section: Resultsmentioning

confidence: 99%

“…Lutrol‐coated ibuprofen tablet cross‐section showing differently crystallized layers under the microscope, with lower ibuprofen content in the coat . Concentration calculated according to Equation .…”

Section: Resultsmentioning

confidence: 99%

“…A universal sampling technique to separate the coat and core sections of the tablets was applied to analyze the respective ibuprofen contents . The ibuprofen concentration difference between the core and the coat was calculated using the following formula:

{normalC}_{A I} = \frac{{normalC}_{c o r e} - {normalC}_{c o a t}}{10} \times 100

where C AI is the concentration of active ingredient, C core is the active ingredient concentration in the tablet core, and C coat is the active ingredient concentration in the tablet.…”

Section: Methodsmentioning

confidence: 99%

“…This is done by measuring the produced tablets' geometry and testing their phase separation quality by measuring the ibuprofen content within the different tablet layers. Again, the universal tablet sampling technique discussed before was employed …”

Section: Methodsmentioning

confidence: 99%

“…working with the right ratio of the mixture; choice of the appropriate primary cooling temperature; and choice of the optimal seeding conditions. By looking at the generated binary phase diagram, the working composition can be determined by choosing the composition ratio that is furthest from the eutectic composition on the coating material side . In this case it is a 90:10 ratio of Lutrol:ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

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Drop forming as a basis for scaling up of the in situ coating process

2016

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Cutting the costs of tablet manufacture is one of the many advantages melt crystallization offers as a technology for producing pharmaceutical coated tablets, compared to conventional tableting procedure. Other advantages include the lower number of steps needed for production, which increases productivity; the lower energy and workforce requirements; and the decreased need for stricter post-production quality control measures while maintaining quality. The scientific term for maintaining quality is ensuring the reproducibility of experimental results. The main focus of this study is to scale up the drop-forming process of coating, in this case of ibuprofen tablets using Lutrol. The main emphasis therefore focuses on transferring the respective optimized conditions that work for the respective system onto the industrial device. This results in the production of tablets with consistent quality in terms of geometry and coat purity. This goes in hand with the extensive modifications applied to the device for the purpose of process scale-up. The final outcome is represented in a scaled-up production of the coated pharmaceutical tablets through the process of melt crystallization, the reproducibility of which as a tablet manufacturing method is also proven.

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“…Differently‐coated cooling surfaces result in the production of tablet batches with different geometries …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

{normalC}_{A I} = \frac{{normalC}_{c o r e} - {normalC}_{c o a t}}{10} \times 100

where C AI is the concentration of active ingredient, C core is the active ingredient concentration in the tablet core, and C coat is the active ingredient concentration in the tablet.…”