The effect of (<scp><i>Cornus mas</i></scp> L.) fruit extract on liver function among patients with nonalcoholic fatty liver: A double‐blind randomized clinical trial

Sangsefidi, Zohreh Sadat; Yarhosseini, Faezeh; Ranjbar, Ali Mohammad; Akhondi-Meybodi, Mohsen; Fallahzadeh, Hossein

doi:10.1002/ptr.7199

Cited by 13 publications

(15 citation statements)

References 27 publications

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“…Fibrosis scores increased significantly in the placebo group. There was also a significant difference in fibrosis scores and changes between the C. mas extract and placebo groups [95].…”

Section: Hepatoprotective Effectmentioning

confidence: 91%

Cornelian Cherry (Cornus mas L.): Insight into its Phytochemistry and Bioactivity

ÇEVİK¹,

Akça²,

SUNTAR³

2022

jrp

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Cornus mas L. (Cornelian cherry) (family Cornaceae) is one of the important medicinal plants with a rich phytochemical profile. It is an ornamental plant with edible fruits possessing therapeutic and nutritional values. The fruits have been used in folk medicine since ancient times. They are red-colored, pear-shaped, oval, and sour taste and are often used in the form of beverages, marmalade, and jams, as well as utilized in the cosmetic industry. Phytochemicals reported for C. mas are phenolic acids, flavonoids, organic acids, anthocyanins, tannins, fatty acids, iridoids, and carotenoids. Especially, the fruits are rich in anthocyanins, vitamin C, and phenolic compounds. The extracts and compounds from C. mas have been investigated for antimicrobial, cytotoxic, anti-inflammatory, antioxidant, antiatherosclerotic, antihyperlipidemic, antidiabetic, anti-colitis, neuroprotective, hepatoprotective, cardioprotective, and nephroprotective activities. The objective of the present review is to summarize the recent studies on the phytoconstituents of C. mas and their biological effects.

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“…Fibrosis scores increased significantly in the placebo group. There was also a significant difference in fibrosis scores and changes between the C. mas extract and placebo groups [95].…”

Section: Hepatoprotective Effectmentioning

confidence: 91%

Cornelian Cherry (Cornus mas L.): Insight into its Phytochemistry and Bioactivity

ÇEVİK¹,

Akça²,

SUNTAR³

2022

jrp

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“…Sangsefidi et al [ 68 , 69 ] investigated the possibility of using anthocyanins derived from cornelian cherry at a dose of 20 mL·day −1 over 12 weeks on changes in the markers of non-alcoholic fatty liver disease ( Table 3 ). They measured alanine aminotransferase, aspartate aminotransferase, and cytokeratin 18 levels, liver fat, and fibrosis score.…”

Section: Health-promotion Effects Of Anthocyanins Derived From Cornel...mentioning

confidence: 99%

Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits

Szot,

Łysiak,

Sosnowska

et al. 2024

Molecules

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The cornelian cherry is a plant that annually provides fruits, drupe-type, ranging in color from yellow through pink, red, carmine, and almost black. Cornelian cherry bears abundant fruit in temperate climate conditions, which means that its dark-colored fruits can be treated as an excellent source of anthocyanins. After consuming, anthocyanins have a protective function in the human body. Raw fruit extracts and their pure isolates, rich in anthocyanins, have a wide spectrum of health-promoting properties. This review focuses on the health-promoting properties of anthocyanins from fruits of cornelian cherry, documented in research conducted in vitro, in vivo, and in humans. The results obtained so far confirm the beneficial effects of anthocyanins on the blood parameters, whose values are important in predicting and assessing the risk and progression of cardiovascular and metabolic diseases. A beneficial effect on molecular and histopathological changes in target organs such as the heart, brain, kidneys, and liver has also been demonstrated. Anthocyanins from cornelian cherry have a strong antioxidant effect, which explains their protective effects on organs and anticancer effects. Moreover, they have antiglycemic, antihyperlipidemic, anti-inflammatory, and antimicrobial properties. The work highlights the perspectives and directions of necessary research.

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“…After 12 weeks, C. mas fruit extract was reduced serum ALT, AST, and CK-18 levels. 35 Curcuma longa L.: Curcumin, the major metabolite of turmeric, is also a popular secondary metabolite subject to biological activity studies. Clinical trials were often conducted with curcumin in efficacy studies against fatty liver disease.…”

Section: Cassia Obtusifolia (L)hs Irwin and Barnebymentioning

confidence: 99%

Herbal Preparations Used Against Fatty Liver Disease: Systematic Review

Karadağ¹,

Demirci²

2022

J Lit Pharm Sci

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The effect of (Cornus mas L.) fruit extract on liver function among patients with nonalcoholic fatty liver: A double‐blind randomized clinical trial

Cited by 13 publications

References 27 publications

Cornelian Cherry (Cornus mas L.): Insight into its Phytochemistry and Bioactivity

Cornelian Cherry (Cornus mas L.): Insight into its Phytochemistry and Bioactivity

Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits

Herbal Preparations Used Against Fatty Liver Disease: Systematic Review

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