The effect of sclareol on growth and cell cycle progression of human leukemic cell lines

Dimas, Kostas; Kokkinopoulos, Dimitrios; Demetzos, Costas; Vaos, Basilios; Marselos, Marios; Malamas, Mixalis; Tzavaras, Theodore

doi:10.1016/s0145-2126(98)00134-9

Cited by 73 publications

(37 citation statements)

References 25 publications

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“…The concentration required for 50% inhibition of the growth (IC 50 ) was 22.5 mM. Recently Dimas et al (1999) reported that sclareol, a labdane-type diterpene from the leaves of Cistus incanus subsp. creticus (L.), kills tumour cells via a cell cycle specific mechanism and induces apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells

Kang

Lee

et al. 2001

Phytotherapy Research

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The inhibitory effect of rotundifuran, a labdane type diterpene isolated from the fruit of Vitex rotundifolia, on the proliferation of human myeloid leukaemia HL-60 cells was examined. The concentration required for 50% inhibition of the growth after 96 h was 22.5 microM. The mode of cell death induced by rotundifuran was found to be apoptosis, which was judged by the morphological alteration of the cells and by the detection of DNA fragmentation using agarose gel electrophoresis. The degree of apoptosis was quantified by a sandwich enzyme immunoassay and flow cytometric analysis. These results suggest that rotundifuran may be used as a potential chemopreventive and chemotherapeutic agent.

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Section: Resultsmentioning

confidence: 99%

Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells

Kang

Lee

et al. 2001

Phytotherapy Research

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“…Sclareol (labd-14-ene-8,13 diol) is a labdane diterpene isolated from the plant Salvia sclarea, which has been shown to induce apoptosis possibly via both the mitochondrial and death receptor pathways (115)(116)(117). Interestingly, formulations of sclareol into non-mitochondria-targeted plain liposomes were found to reduce the compound's cytotoxicity (118).…”

Section: Targeting Cancer Cell Mitochondriamentioning

confidence: 99%

From Serendipity to Mitochondria-Targeted Nanocarriers

Weissig

2011

Pharm Res

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This review illustrates how a random observation at the laboratory bench has helped pave the way towards the development of organelle-targeted pharmaceutical nanocarriers. A fortuitous discovery in the mid 1990s involving the self-assembly of a molecule, known to accumulate inside mitochondria, has lead to the development of subcellular nanocarriers suited for the selective delivery of biologically active molecules to mitochondria inside living mammalian cells. Applications for mitochondria-specific drug and DNA delivery are described, the current state-of-the-art of mitochondrial drug targeting technology is reviewed, and its future perspectives are discussed.

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“…These components can be found in essential oils such as those from Salvia spp. including Salvia sclarea or clarysage [68][69][70]. Tricyclic diterpenes that occur in essential oils include phyllocladene and 16-kaurene [4].…”

Section: Diterpenesmentioning

confidence: 99%