The effect of Salinum on the symptoms of dry mouth: a pilot study

Abstract

The effect of a new saliva substitute, Salinum, was tested in 37 patients with severe symptoms of reduced salivation. The majority of the patients had suffered from hyposalivation and dry mouth for more than 8 years. The saliva substitute consisted of a water soluble extract of linseed. The physical properties of this extract are similar to those of the glycoproteins of the salivary secretions. The patients used the saliva substitute for a seven days period. Prior to the use of the extract the patients reported that the most severe symptoms of decreased salivation were a feeling of dryness in the mouth and burning sensations in the tongue, pharynx and oesophagus, The majority of the patients reported that the use of Salinum reduced the symptoms of hyposalivation. Great variation in effect occurred from patient to patient. Generally the patients with the most severe symptoms experienced the greatest relief of the symptoms when they used Salinum. Although of short duration the results of this pilot study indicate that an extract of linseeds may compensate for some aspects of the consequences of reduced salivation. Further studies are needed to elucidate the feasibility of the extract as saliva replacement.

Saliva substitutes for the treatment of radiation-induced xerostomia—a review

“…For ten patients from the postradiation group (14 patients), the symptoms of xerostomia decreased significantly. Some patients reported particular relief during the night; the symptoms taste, speech, chewing, and swallowing were reduced to a varying degree [45]. As no control groups were included in this study, these results have to be interpreted with caution.…”

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

“…Three studies assessed linseed fluid used ad libitum for 1-and 3-week periods post-irradiation and found that it reduces xerostomia [135][136][137]. Also, it was noted that the effect tended to increase with increasing time of use of the fluid (during a 3-week period) [135], that generally the patients with the most severe symptoms experienced the greatest relief [137], and that linseed fluid was preferred to CMC fluid [135].…”

“…Also, it was noted that the effect tended to increase with increasing time of use of the fluid (during a 3-week period) [135], that generally the patients with the most severe symptoms experienced the greatest relief [137], and that linseed fluid was preferred to CMC fluid [135].…”

Syndrome de Gougerot-Sjögren: manifestations buccales et prise en charge

“…Elles sont présentées sous différentes formes galéniques (liquide, pastille ou chewinggum). On trouve également dans le commerce d'autres substituts salivaires comme l'oxyde de polyéthylène [22] ou des extraits de polysaccharides provenant de graines de lin [23]. Le premier semble plus efficace que la méthylcellulose pour réduire les symptômes de xérostomie, le second donne des résultats satisfaisants chez environ 75 % des patients.…”