The effect of salbutamol on early and late asthmatic responses, bronchial hyperreactivity and airway leukocyte infiltration in guinea-pigs

Temporal relationships between leukocytes, IL-5 and IL-8 in guinea pig lungs, plasma cortisol and airway function after antigen challenge

“…There has been some criticism of the conscious guinea pig model for measurement of specific airway conductance because it is regarded as an obligatory nose breather and the changes in sG aw could arise from changes in upper airway resistance. This, however, can largely be discounted since histamine and carbachol which act exclusively on lower airway smooth muscle [24] exert profound effects and we have shown that the bronchoconstriction by histamine and allergen can be inhibited by the airway smooth muscle relaxant, salbutamol [25].…”