The effect of (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine (HPMPC) on bovine herpesvirus-1 (BHV-1) infection and reactivation in cattle

Gilliam, S.E.; Field, Hugh J.

doi:10.1016/0166-3542(93)90056-o

Cited by 14 publications

(10 citation statements)

References 19 publications

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“…8,9 Cidofovir is a nucleoside analogue of deoxycytidine monophosphate that has potent antiviral effects in vitro and in vivo against several herpesviruses of human and veterinary importance. [10][11][12][13] For example, topical application of cidofovir at concentrations of 0.02 to 0.1 mg/mL is effective for treating New Zealand White rabbits with keratitis attributable to infection with herpes simplex virus (HSV)-1, and cidofovir is widely used to treat people with retinitis associated with cytomegalovirus infection. [14][15][16] In vitro efficacy of cidofovir against FHV-1 has been documented.…”

mentioning

confidence: 99%

Effects of cidofovir on cell death and replication of feline herpesvirus-1 in cultured feline corneal epithelial cells

Sandmeyer

Keller²,

Bienzle³

2005

ajvr

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confidence: 99%

Effects of cidofovir on cell death and replication of feline herpesvirus-1 in cultured feline corneal epithelial cells

Sandmeyer

Keller²,

Bienzle³

2005

ajvr

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“…Several herpesvirus antivirals licensed for human medicine have been evaluated for use in veterinary patients, including cats (Groth et al, 2013), horses (Garre et al, 2007(Garre et al, , 2009 and cattle (Korvasova et al, 2012). Calves with a latent BHV-1 infection had reduced clinical signs and viral replication when given a single dose of 20 mg/kg of (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl) cytosine (HPMPC) one day prior to iatrogenic recrudescence of the infection by corticosteroid administration (Gilliam and Field, 1993). However, viral shedding was not eliminated nor was establishment of latency prevented, presumably leaving treated calves capable of transmitting the virus to susceptible cohorts.…”

Section: Resultsmentioning

confidence: 99%

Potential applications for antiviral therapy and prophylaxis in bovine medicine

Newcomer

Walz

Givens

2014

Anim. Health. Res. Rev.

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Viral disease is one of the major causes of financial loss and animal suffering in today's cattle industry. Increases in global commerce and average herd size, urbanization, vertical integration within the industry and alterations in global climate patterns have allowed the spread of pathogenic viruses, or the introduction of new viral species, into regions previously free of such pathogens, creating the potential for widespread morbidity and mortality in naïve cattle populations. Despite this, no antiviral products are currently commercially licensed for use in bovine medicine, although significant progress has been made in the development of antivirals for use against bovine viral diarrhea virus (BVDV), foot and mouth disease virus (FMDV) and bovine herpesvirus (BHV). BVDV is extensively studied as a model virus for human antiviral studies. Consequently, many compounds with efficacy have been identified and a few have been successfully used to prevent infection in vivo although commercial development is still lacking. FMDV is also the subject of extensive antiviral testing due to the importance of outbreak containment for maintenance of export markets. Thirdly, BHV presents an attractive target for antiviral development due to its worldwide presence. Antiviral studies for other bovine viral pathogens are largely limited to preliminary studies. This review summarizes the current state of knowledge of antiviral compounds against several key bovine pathogens and the potential for commercial antiviral applications in the prevention and control of several selected bovine diseases.

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“…This included various animal models for herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) but also murine and rat cytomegalovirus (CMV), equine herpesvirus type 1 (EHV-1) 189 and bovine herpesvirus type 1 (BHV-1). 190 The activity of cidofovir against EHV-1 was recently confirmed (and extended to PMEDAP), 191 and both cidofovir and PMEDAP were also found active against feline herpesvirus type 1 (FHV-1). 192,193 Of direct veterinary importance, Fontenelle et al 194 found that topical ophthalmic application of cidofovir significantly decreased the amount of viral shedding and the severity of clinical disease in cats with experimentally induced ocular FHV-1 infection.…”

Section: D8 Therapeutic Potential Of Cidofovir and Anps For Veterinamentioning

confidence: 93%

Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes, and paraductions

Clercq

2009

Medicinal Research Reviews

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This review article presents the fourth part (part D) in the series of stories on antiviral drug discovery. The stories told in part D focus on: (i) the cyclotriazadisulfonamide compounds; (ii) the {5-[(4-bromophenylmethyl]-2-phenyl-5H-imidazo[4,5-c]pyridine} compounds; (iii) (1H,3H-thiazolo[3,4-a]benzimidazole) derivatives; (iv) T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) and (v) its structurally closely related analogue pyrazine 2-carboxamide (pyrazinamide); (vi) new strategies for the treatment of hemorrhagic fever virus infections, including, as the most imminent, (vii) dengue fever, (viii) the veterinary use of acyclic nucleoside phosphonates; (ix) the potential (off-label) use of cidofovir in the treatment of papillomatosis, particularly RRP (recurrent respiratory papillomatosis); and (x) finally, the prophylactic use of tenofovir to prevent HIV infections.

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The effect of (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine (HPMPC) on bovine herpesvirus-1 (BHV-1) infection and reactivation in cattle

Cited by 14 publications

References 19 publications

Effects of cidofovir on cell death and replication of feline herpesvirus-1 in cultured feline corneal epithelial cells

Effects of cidofovir on cell death and replication of feline herpesvirus-1 in cultured feline corneal epithelial cells

Potential applications for antiviral therapy and prophylaxis in bovine medicine

Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes, and paraductions

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