Effects of cidofovir on cell death and replication of feline herpesvirus-1 in cultured feline corneal epithelial cells

Sandmeyer, Lynne S; Keller, Charlotte; Bienzle, Dorothee

doi:10.2460/ajvr.2005.66.217

Cited by 23 publications

(22 citation statements)

References 22 publications

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“…Compounded into a 0.5% ophthalmic solution, it is efficacious against FHV-1 and is stable when stored frozen or refrigerated for at least 6 months (Fontanelle et al, 2008;Stiles et al, 2010). Additional benefits include lack of ocular irritation and a long tissue half-life, so that twice daily administration is adequate (Sandmeyer et al, 2005;van der Meulen et al, 2006). Acyclovir has a low efficacy against FHV-1 compared to its efficacy against human herpes simplex virus (HSV), and is not recommended for treatment of cats (Nasisse et al, 1989;van der Meulen et al, 2006).…”

Section: Treatmentmentioning

confidence: 99%

Ocular manifestations of feline viral diseases

Stiles

2014

The Veterinary Journal

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Feline viral diseases are common and cats can be presented with a variety of clinical manifestations. Ocular disease associated with viral pathogens is not unusual, particularly with viruses causing upper respiratory tract disease in cats, such as feline herpesvirus type 1 and feline calicivirus. These agents mainly cause ocular surface disease. Other viruses, such as feline immunodeficiency virus and feline coronavirus, can cause uveitis, while feline leukemia virus can induce ocular lymphosarcoma. This review covers the most common viral pathogens of cats that cause ocular manifestations, the specific features of the ocular diseases caused by these viruses and therapeutic recommendations.

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Section: Treatmentmentioning

confidence: 99%

Ocular manifestations of feline viral diseases

Stiles

2014

The Veterinary Journal

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“…Since corneal lesions are an important disease manifestation, both during both the acute phase and as a result of reactivation, finding an effective therapy against development of ocular disease has high priority. Sandmeyer et al [115] have reported the development of primary corneal cell culture system, which is useful for in vitro pathogenesis of ocular disease and also for the testing of potential antivirals [116]. Using this system they showed that IFN- α was not toxic to ocular cells and had a limited effect of virus production in FeHV-1-infected corneal cells.…”

Section: In Vitro Approaches To Molecular Pathogenesismentioning

confidence: 99%

Felid Herpesvirus Type 1 Infection in Cats: A Natural Host Model for Alphaherpesvirus Pathogenesis

Maes

2012

ISRN Veterinary Science

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Feline herpesvirus 1 (FeHV-1) is an alphaherpesvirus that causes feline viral rhinotracheitis, an important viral disease of cats on a worldwide basis. Acute FeHV-1 infection is associated with both upper respiratory and ocular signs. Following the acute phase of the disease lifelong latency is established, primarily in sensory neuronal cells. As is the case with human herpes simplex viruses, latency reactivation can result in recrudescence, which can manifest itself in the form of serious ocular lesions. FeHV-1 infection in cats is a natural host model that is useful for the identification of viral virulence genes that play a role in replication at the mucosal portals of entry or are mediators of the establishment, maintenance, or reactivation of latency. It is also a model system for defining innate and adaptive immunity mechanisms and for immunization strategies that can lead to better protection against this and other alphaherpesvirus infections.

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“…Acyclovir, which is widely used in human medicine, does not seem to have good activity in vitro against FeHV-1 [81,92,138,148,152] and both acyclovir and the acyclovir prodrug valacyclovir, are too toxic at therapeutic levels for oral administration to cats [96,102,126]. However, a number of other antiviral agents such as ganciclovir and cidofovir appear to have greater efficacy in vitro against FeHV-1, and may prove to be useful clinically [81,114,138].…”

Section: Treatmentmentioning

confidence: 99%