The effect of rutin on lipid profile and liver function enzymes on alloxan induced hyperglycaemic wistar rats

Tanko, Y.; Jimoh, Abdulgafar Olayiwola; Sulaiman, Indra Anas; Mohammed, K A; Salisu, A I; Yusuf, Rita; Musa, S.A.

doi:10.4314/bajopas.v10i1.30

Cited by 10 publications

(14 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidants are the type of molecules that nullify harmful free radicals, produced through a series of reactions ( Joseph et al., 2009 ; George and Adegoke, 2011 , 2012 ; Tanko et al., 2013 ), that are detrimental to living cells, spoil foods, damage materials such as rubber, gasoline, and lubricating oil. Antioxidants terminate these series of reactions through the elimination of free radical intermediates and inhibiting other oxidation reactions ( Sies, 1997 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of commonly used food additives on haematological parameters of Wistar rats

Femi-Oloye

Owoloye

Olatunji-Ojo

et al. 2020

Heliyon

View full text Add to dashboard Cite

This study was done to investigate the effects of common food additives such as sodium benzoate (SB) and ascorbic acid (AA) on haematological parameters of male Wistar rats. Forty-eight (48) male albino rats with an average weight of 105 g were grouped into twelve (n = 4) of Basal Control and other 11 groups orally administered 1 mg of SB, 10 mg of SB, 10 mg of AA, 0.2 mg of AA + 0.5 mg of SB, 0.2 mg of AA + 1 mg of SB, 0.2 mg of AA + 10 mg of SB, 0.2 mg of SB + 0.1 mg of AA, 0.2 mg of SB + 0.5 mg of AA, carbonated soft drinks (CSD)+ 0.1 mg of AA, CSD + 1 mg of AA and CSD + 10 mg of AA, respectively for 21 non-consecutive days. At the end of the experiment, blood samples were collected in EDTA anticoagulant tubes, haematological parameters were evaluated, and data were analyzed. There was a dose-dependent increase (p < 0.05) in White Blood Cell counts of SB treated rats compared with the control group. The lymphocyte exhibited significant reduction (p < 0.05) in the groups treated with 1mg SB and 10mg SB/kg bodyweight of 67 ± 2.96 and 58 ± 4.18%, respectively. The mean corpuscular haemoglobin showed no significant difference at 95% confidence interval. However, mean corpuscular haemoglobin concentration, haematocrit and platelet were affected by an increase in the concentrations of SB. High SB concentrations increased the destruction of erythrocytes, which directly increased the catabolism of haemoglobin. However, AA administration mitigated the adverse effects of SB on the haematological parameters of the animal.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of commonly used food additives on haematological parameters of Wistar rats

Femi-Oloye

Owoloye

Olatunji-Ojo

et al. 2020

Heliyon

View full text Add to dashboard Cite

show abstract

“…The results of the present study corroborate the finding that shows a decline in the activities of antioxidant enzymes and increased MDA concentration in diabetic rats [ 49 ]. SOD dismutases superoxide to H 2 O 2 , whereas CAT detoxifies H 2 O 2 to H 2 O, thereby protecting the tissues from highly reactive OH · [ 15 ]. The increased activities of serum SOD and CAT due to Vit-C treatment, apparently, resulted in the amelioration of the toxic effects of the ROS, generated in excess during diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Their use as a form of treatment regimen for diseases such as T1DM is currently an area of limited investigation [ 13 ]. The vitamin has been shown to play vital roles in DNA repair, reducing the extent of DNA damage [ 14 ] and scavenging ROS, caused by oxidative stress [ 15 ]. Thus, we hypothesized that Vit-C and probiotic may ameliorate the hyperglycaemia, oxidative stress and dyslipidaemia in DM.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C

et al. 2016

View full text Add to dashboard Cite

Clinical and experimental evidence suggests that hyperglycaemia is responsible for the oxidative stress in diabetes mellitus. The study was designed to investigate the comparative effects of probiotic and vitamin C (Vit-C) treatments on hyperglycaemia, oxidative stress and dyslipidaemia in alloxan-induced diabetic rats. Type 1 diabetes (T1DM) was induced in male Wistar rats by a single intraperitoneal (i.p.) injection of alloxan (150 mg/kg). Six groups of the animals received the following treatment regimens for four weeks: (1) Normal saline, per os; (2) alloxan (150 mg/kg, i.p.); (3) alloxan (150 mg/kg) + insulin (4 U/kg, subcutaneously); (4) alloxan (150 mg/kg) + probiotic (4.125 × 106 CFU/100 mL per os); (5) alloxan (150 mg/kg) + Vit-C (100 mg/kg, i.m.); (6) alloxan (150 mg/kg) + probiotic (4.125 × 106 CFU/100 mL per os) + Vit-C (100 mg/kg, intramuscularly). Probiotic + Vit-C decreased (p < 0.05) blood glucose concentration in diabetic treated group, when compared with the untreated diabetic group. Probiotic + Vit-C reduced malondialdehyde concentration, in the serum, brain and kidneys, respectively, but increased the activity of antioxidant enzymes. Probiotic and Vit-C may be more effective than Vit-C alone, in ameliorating hyperglycaemia, oxidative stress and dyslipidaemia in alloxan-induced diabetic rats.

show abstract

“…Wistar rats were fasted for about 12 -18 hours, after which diabetes mellitus was induced by a single intraperitoneal injection of Alloxan monohydrate dissolved in 0.9% cold normal saline solution at a dose of 150 mg/kg body weight. 21 Alloxan produces fatal hypoglycaemia 22 and to prevent this, the rats were treated with 20% glucose solution orally for 6 hours. After which they were placed on 5% glucose solution for 24 hours.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Evaluation of Hypoglycaemic and Antioxidant Activity of Moringa oleifera Root in Normal and Alloxan-Induced Diabetic Rats

Umar¹,

Mohammed²,

Nuhu³

et al. 2018

TJNPR

View full text Add to dashboard Cite

Moringa oleifera is traditionally used for treatment of diarrhea, diabetes mellitus, rheumatism, venomous bites, for cardiac stimulation and as a diuretic. The aim of this study was to investigate the hypoglycaemic and antioxidant activity of M. oleifera root in normal and alloxan-induced diabetic rats. The root was extracted with n-hexane, ethyl acetate and methanol successively using soxhlet apparatus. All the extracts were subjected to phytochemical screening and toxicity study. The powder and methanol extracts were subjected to anti-diabetic evaluation using alloxaninduced diabetes in rats for 28 days. Glibenclamide was used as standard drug. The anti-diabetic effect of the extract was evaluated by measuring changes in blood glucose level, haematological indices, biochemical parameters, oxidative stress biomarkers and pancreatic tissue. Phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, carbohydrate, cardiac glycosides and saponins. LD50 was above 5000 mg/kg and did not cause mortality in all the tested rats. Both the methanol extract and powdered root showed significant reduction (p<0.05) in blood glucose level after treatment. Also, the concentrations of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) increased significantly (p<0.05) as compared with the diabetic control. Histopathological examination of the pancreas from diabetic rats showed degenerative changes in β-cells. In the treatment groups, there was a significant reversal to the damage done to the islet of Langerhans. This study has shown that M. oleifera root possesses hypoglycaemic effect and ameliorates other adverse diabetic conditions imposed by alloxan-induced diabetes on the experimental rats.

show abstract

The effect of rutin on lipid profile and liver function enzymes on alloxan induced hyperglycaemic wistar rats

Cited by 10 publications

References 7 publications

Effects of commonly used food additives on haematological parameters of Wistar rats

Effects of commonly used food additives on haematological parameters of Wistar rats

Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C

Evaluation of Hypoglycaemic and Antioxidant Activity of Moringa oleifera Root in Normal and Alloxan-Induced Diabetic Rats

Contact Info

Product

Resources

About