The effect of rumen epithelial development on metabolic activities and ketogenesis by the tissue in vitro

Giesecke, D.; Beck, Ulrike; Wiesmayr, Solveig; Stangassinger, M.

doi:10.1016/0305-0491(79)90118-4

Cited by 25 publications

(22 citation statements)

References 12 publications

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“…Thus, the function of MCT1 in early life may not (only) be the elimination of end products of intracellular catabolism but (also) the uptake of energyrich substrates. Supporting that view, it has been shown that the developing epithelium has a relatively high rate of lactate utilisation compared with older epithelia (Giesecke et al, 1979). Lactate taken up by the epithelial cells can be converted to pyruvate which provides energy by aerobic pathways.…”

Section: Discussionmentioning

confidence: 94%

Post‐natal changes inMCT1 expression in the forestomach of calves

Pfannkuche

Taifour

Steinhoff‐Wagner

et al. 2013

Animal Physiology Nutrition

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The monocarboxylate transporter 1 (MCT1) has been demonstrated to be involved in the transfer of short-chain fatty acids (SCFA) and/or their intraepithelial metabolites from the rumen to the blood. As MCT1 plays a role in SCFA transfer, it is assumed that SCFA are the main substrates influencing its expression. However, there are hints that MCT1 may also be expressed during the early life of the animal when SCFA are not released in the forestomach. To figure out whether MCT1 expression in the forestomach is influenced independently of SCFA during that period, we studied post-natal MCT1 expression immunohistochemically in the epithelia of omasum, atrium ruminis, saccus dorsalis ruminis, saccus ventralis ruminis and reticulum of calves born preterm and at term. The calves were nourished by colostrum or by milk-based formula diet. MCT1 could be found in all the forestomach compartments tested, even in preterm calves. The protein was mainly oriented to the luminal side in the immature epithelium 24 h after birth. Orientation to the blood side of the cells developed during the first 4 days after birth. In the rumen epithelia (but not in the other forestomach compartments tested), orientation of MCT1 to the blood side of the cells was paralleled by an increase in the overall expression rate during the first 4 days after birth. As lactate levels were very high directly after birth, a lactate-dependent substrate induction may have been the underlying mechanism. However, non-specific changes due to general differential processes might also be the cause. Both early upregulation of MCT1 and high blood lactate levels may provide the epithelia with lactate as energy source.

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Section: Discussionmentioning

confidence: 94%

Post‐natal changes inMCT1 expression in the forestomach of calves

Pfannkuche

Taifour

Steinhoff‐Wagner

et al. 2013

Animal Physiology Nutrition

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“…Beck et al (1984) have shown that increasing the butyrate concentration in the incubation medium produces a decrease in the proportion of butyrate oxidized to C02 and an increase in the proportion of ketone-body production. The presence of glucose significantly increases ketogenesis from butyrate and decreases its oxidation to C02, whereas NH4+ and pyruvate have the opposite effect (Stangassinger et al 1979;Beck et al 1984;Giesecke et al 1985). Giesecke et al (1985) suggested that any metabolite producing an increase in NADH:NAD+ in the epithelium may stimulate ketogenesis and spare butyrate from oxidation, The effects of propionate and acetate on ketone-body production are less clear.…”

Section: Biochemical Path Waysmentioning

confidence: 99%

“…In the preruminant the primary energy substrate available for the epithelium is blood glucose, while thereafter large amounts of lactate and VFA produced by rumen fermentation become available. After a short postnatal development period of about 2 weeks, the rumen epithelium is able to oxidize glucose, lactate and butyrate at high rates (Giesecke et al 1979;Baldwin & Jesse, 1992). By the time of weaning, at about 8 weeks of age, the capacity for glucose uptake by the rumen epithelium diminishes (Giesecke et al 1979), epithelial cells seem to lose their ability to oxidize glucose at high rates and other substrates such as VFA may become the primary oxidative energy source: by 8 weeks of age butyrate oxidation rate is 10-fold higher than glucose oxidation rate (Baldwin & Jesse, 1992).…”

Section: Remond and Others Energy Substrate Utilization Accordingmentioning

confidence: 99%

“…By the time of weaning, at about 8 weeks of age, the capacity for glucose uptake by the rumen epithelium diminishes (Giesecke et al 1979), epithelial cells seem to lose their ability to oxidize glucose at high rates and other substrates such as VFA may become the primary oxidative energy source: by 8 weeks of age butyrate oxidation rate is 10-fold higher than glucose oxidation rate (Baldwin & Jesse, 1992). After the postnatal development period, the ability of the epithelium to oxidize butyrate is independent of epithelial growth (Giesecke et al 1979;Baldwin & Jesse, 1992), whereas the capacity of rumen cells to produce ketone bodies from VFA, which is very low before weaning, rapidly increases thereafter (Giesecke et al 1979;Baldwin & Jesse, 1992). The metabolic maturation of rumen epithelium thus occurs with the functional development of the rumen.…”

Section: Remond and Others Energy Substrate Utilization Accordingmentioning

confidence: 99%

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Energy substrates for the rumen epithelium

1995

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“…In the present study, SGLT1 mRNA was expressed in the forestomach epithelia isolated from cattle and goats whose forestomachs were not yet developed. Giesecke et al . (1979) reported relatively high glucose oxidation rates by tissues of the rumen isolated from 2 week old lambs.…”

Section: Discussionmentioning

confidence: 99%

Expression of mRNA for sodium‐glucose transporter 1 and fatty acid translocase in the ruminant gastrointestinal tract before and after weaning

Hayashi

Yonezawa

Kanetani

et al. 2005

Animal Science Journal

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The mRNA expression of sodium-glucose transporter 1 (SGLT1) and fatty acid translocase (CD36) in the gastrointestinal tract of Holstein cattle and Saanen goats before and after weaning was investigated. Before weaning, the expression of both SGLT1 and CD36 was highest in the jejunum, relative to the other parts of the gastrointestinal tract in both species. The expression of SGLT1 and CD36 in the duodenum was second highest in the goats. After weaning, SGLT1 and CD36 expression in the small intestine significantly decreased in both species. The expression of both types of transporters was also detected in the forestomach. From these results, it was concluded that the jejunum is probably the major absorption site for glucose and long-chain fatty acids before weaning, and that the expression of both types of transporters decreases after weaning in cattle and goats.

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The effect of rumen epithelial development on metabolic activities and ketogenesis by the tissue in vitro

Cited by 25 publications

References 12 publications

Post‐natal changes inMCT1 expression in the forestomach of calves

Post‐natal changes inMCT1 expression in the forestomach of calves

Energy substrates for the rumen epithelium

Expression of mRNA for sodium‐glucose transporter 1 and fatty acid translocase in the ruminant gastrointestinal tract before and after weaning

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