Energy substrates for the rumen epithelium

Rémond, Didier; Ortigues, Isabelle; Jouany, J. P.

doi:10.1079/pns19950040

Cited by 60 publications

(64 citation statements)

References 47 publications

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“…An example is the explanation of the stimulatory effect of propionate and glucose supply on the conversion of butyrate to b-OHbutyrate by rumen epithelia in vitro (Rémond et al 1995;Baldwin & Jesse, 1996), which seems in line with in vivo observations on the effect of propionate and glucose on net portal fluxes (Gross et al 1990b;Krehbiel et al 1992;Seal & Parker, 1994). Principles required for representation of these processes include:…”

Section: Effect Of Metabolite Concentrations On Metabolic Processesmentioning

confidence: 81%

“…5), whereas the reverse is not the case. Besides full oxidation, a variable proportion of butyrate is metabolised to b-OH-butyrate (Bergman, 1990;Britton & Krehbiel, 1993;Rémond et al 1995) and part of the propionate may be converted into lactate. Both lactate and propionate are precursors for gluconeogenesis.…”

Section: Ruminantsmentioning

confidence: 99%

“…Moreover, various nutritional factors affect the relative proportion of acetate, propionate and butyrate in the rumen (Baldwin, 1995;Bannink et al 2006b). Depending on the type of VFA involved, VFA are more or less mutually dependent with respect to the enzyme kinetics of their metabolic conversion (Ash & Baird, 1973;Harmon et al 1991;Rémond et al 1995;Bannink et al 2000;equation 4). This dependency is characterised by competitive inhibition and causes butyrate to strongly inhibit the activity of CoAsynthetases for acetate and propionate (Rémond et al 1995;Fig.…”

Section: Ruminantsmentioning

confidence: 99%

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Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling

et al. 2006

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A rationale is given for a modelling approach to identify the mechanisms involved in the functioning and metabolic activity of tissues in the wall of the gastrointestinal tract. Maintenance and productive functions are discussed and related to the distinct compartments of the gastrointestinal tract and the metabolic costs involved. Functions identified are: tissue turnover; tissue proliferation; ion transport; nutrient transport; secretions of digestive enzymes, mucus and immunoglobulins; production of immune cells. The major nutrients involved include glucose, amino acids and volatile fatty acids. In vivo measurements of net portal fluxes of these nutrients in pigs and ruminants are evaluated to illustrate the complexity of physiology and metabolic activity of the gastrointestinal tract. Experimental evidence indicates that high, but variable and specific, nutrient costs are involved in the functioning of the gastrointestinal tract.

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Section: Effect Of Metabolite Concentrations On Metabolic Processesmentioning

confidence: 81%

Section: Ruminantsmentioning

confidence: 99%

Section: Ruminantsmentioning

confidence: 99%

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Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling

et al. 2006

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“…Functional adaptation of rumen epithelial cells to high-concentrate feeding also includes a lowering of Na + /K + -ATPase mRNA expression and a decreased amount of Na + /K + -ATPase protein per cell membrane surface area. The reduced abundance of this major energy-consuming process will make more energy available for other cellular functions such as protein synthesis and proliferation (Remond et al, 1995). Additional research is needed to further probe the differences between the cell types of the multilayered rumen epithelium to better understand functional adaptation processes.…”

Section: Resultsmentioning

confidence: 99%

“…About 65% to 85% of the short-chain fatty acids (SCFA) produced by intraruminal carbohydrate fermentation are absorbed across the rumen epithelium which is also known to be the main site of Na + and Mg 2+ uptake (Dobson, 1959;Pfeffer and Rahman, 1974;Remond et al, 1995). The transport capacity of the rumen epithelium for these substrates is known to increase markedly with higher levels of metabolizable energy (ME) intake and feeding of highconcentrate rations (Gaebel et al, 1987;Sehested et al, 1997;Uppal et al, 2003;Shen et al, 2004;Etschmann et al, 2009).…”

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confidence: 99%

Altered Na<sup>+</sup>/K<sup>+</sup>-ATPase expression plays a role in rumen epithelium adaptation in sheep fed hay ad libitum or a mixed hay/concentrate diet

Kuzinski¹,

Žitňan²,

Viergutz³

et al. 2011

Vet. Med. - Czech

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ABSTRACT:In this study we investigated rumen papillae morphology and the localization and expression of the Na + /K + -ATPase in eight sheep fed hay ad libitum (h) or hay ad libitum plus additional concentrate (h/c). Four sheep were provided with the ad libitum h-diet for the complete three-week experimental period. The second group of four sheep received the h-diet for only one week and was fed the mixed hay/concentrate (h/c) diet for another two weeks. The amount of concentrate supplement was stepwise increased from 150 to 1000 g/day and given in two meals. Following slaughter rumen papillae from the atrium ruminis (AR), the rumen ventralis (RV) and the ventral blind sac (BSV) were fixed and examined for morphological changes and Na + /K + -ATPase localization by morphometric methods and immunohistochemistry. Ruminal epithelial cells (REC) originating from the strata basale to granulosum were also isolated. Cellular Na + /K + -ATPase expression (mRNA and protein) and differentiation state were determined by RT-PCR, Western blot, and flow cytometry. Compared with data from h-fed sheep, morphometric analysis revealed an increased length and width of rumen papillae in h/c-fed sheep, resulting in a marked 41% and 62% increase in rumen papillae surface in AR and RV, respectively. The rumen mucosa of h/c-fed sheep was characterized by a predominant stratum corneum (42 ± 0.7 µm vs. 28 ± 0.5 µm), but the thickness of the metabolically active cell layers remained unchanged. REC suspensions from sheep fed the h/c diet generally contained more cells (7.30 ± 0.83 vs. 3.49 ± 0.52 × 10 7 /ml; P < 0.001) and an increased proportion of REC positive for basal cytokeratin and for the differentiation marker cytokeratin 10 (P < 0.05). Cellular (cell membrane) and epithelial (stratum basale to stratum granulosum) Na + /K + -ATPase localization was similar between rumen regions and was not changed by concentrate feeding. After two weeks on the h/c-diet, a 96% increase in the absolute number of Na + /K + -ATPasepositive REC (6.56 ± 0.84 vs. 3.35 ± 0.51 × 10 7 /ml; P = 0.003) and a 61% elevation (P = 0.043) in Na + /K + -ATPase protein expression in REC from the upper third of the suprabasal cell layers were found. Moreover, a two-fold (P = 0.001) elevation in cell membrane surface area accompanied by a reduction (1.19 × 10

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Associations between the rumen microbiota and carcass merit and meat quality in beef cattle

Holman,

Gzyl,

Scott

et al. 2024

Appl Microbiol Biotechnol

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The rumen microbiota is important for energy and nutrient acquisition in cattle, and therefore its composition may also affect carcass merit and meat quality attributes. In this study, we examined the associations between archaeal and bacterial taxa in the rumen microbiota of beef cattle and 12 different attributes, including hot carcass weight (HCW), dressing percentage, ribeye area (REA), intramuscular fat content, marbling score, fat thickness, yield grade, moisture content, purge loss, and shear force. There were significant correlations between the relative abundance of certain archaeal and bacterial genera and these attributes. Notably, Selenomonas spp. were positively correlated with live weight and HCW, while also being negatively correlated with purge loss. Members of the Christensenellaceae R-7, Moryella, and Prevotella genera exhibited positive and significant correlations with various attributes, such as dressing percentage and intramuscular fat content. Ruminococcaceae UCG-001 was negatively correlated with live weight, HCW, and dressing percentage, while Acidaminococcus and Succinivibrionaceae UCG-001 were negatively correlated with intramuscular fat content, moisture content, and marbling score. Overall, our findings suggest that specific changes in the rumen microbiota could be a valuable tool to improve beef carcass merit and meat quality attributes. Additional research is required to better understand the relationship between the rumen microbiota and these attributes, with the potential to develop microbiome-targeted strategies for enhancing beef production. Key points • Certain rumen bacteria were associated with carcass merit and meat quality • Moryella was positively correlated with intramuscular fat in beef carcasses • Acidaminococcus spp. was negatively correlated with marbling and intramuscular fat

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Energy substrates for the rumen epithelium

Cited by 60 publications

References 47 publications

Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling

Physiology, regulation and multifunctional activity of the gut wall: a rationale for multicompartmental modelling

Altered Na<sup>+</sup>/K<sup>+</sup>-ATPase expression plays a role in rumen epithelium adaptation in sheep fed hay ad libitum or a mixed hay/concentrate diet

Associations between the rumen microbiota and carcass merit and meat quality in beef cattle

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