The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin

Kim, Soo Hwa; Seo, Hye Sook; Jang, Bo‐Hyoung; Shin, Yong Cheol; Ko, Seong Gyu

doi:10.1007/s13596-014-0152-8

Cited by 6 publications

(6 citation statements)

References 42 publications

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“…This result was coherent with preceding studies reporting the ability of the natural plant extracts to inhibit elastase activity was due to the presence of polyphenols in it [16,33]. Elastase inhibitory effect of 22 Korean traditional herbal medicine was conducted by Kim et al [34] and they found out that among those herbal medicines tested, Rhus vernciflua stokes (RVS) inhibit significant elastase and tyrosinase activity. In the present study, it demonstrates human elastase inhibition activity by L. pumila, a traditional Malaysian medicinal plant for the first time.…”

Section: Anti-inflammatory Activity Of L Pumila Extractssupporting

confidence: 89%

Anti-inflammatory Activity of Polyphenols from Labisia pumila Leaves Extract

Syed Hassan,

Hasham,

Hashim

et al. 2024

Mal. J. Fund. Appl. Sci.

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Non-Steroidal Anti-inflammatory Drugs (NSAIDs) represent a class of pharmaceutical agents that are frequently misused and misconstrued within the medical landscape. While demonstrably efficacious in providing transient pain relief, NSAIDs do not effectively address the fundamental etiology of pain and are associated with a spectrum of potential adverse effects. Labisia pumila var alata also known as "Kacip Fatimah" has been traditionally used which is attributed to its antioxidant properties. Nonetheless, little attempt has been made to examine its antioxidant and anti-inflammatory characteristics. This study determined the molecular interactions and inhibitory activity profiles of L. pumila methanolic extract (LPE) against the corresponding enzymes via in chemico and in silico approaches. In chemico analysis was done on antioxidant activity and anti-inflammatory properties of L. pumila. The findings indicated that LPE exhibit the potent anti-inflammatory activity. Through high-performance liquid chromatography, it was shown that LPE had the highest gallic acid concentration at 10.74 ± 2.23 mg/mL. LPE did not exhibit cytotoxicity up to 100 µg/mL and displayed optimal protective against UVB-irradiation at 50 µg/mL towards HSF1184 Fibroblast cell line. LPE exhibited potent anti-inflammatory activity as it inhibited elastase and COX-2. Molecular docking studies indicated that gallic acid has a good affinity for collagenase (˗5.68 kcal/mol), elastase (˗4.88 kcal/mol) and COX 2 (˗4.91 kcal/mol). These findings collectively suggested that L. pumila extract has significant potential for the formulation of the natural anti-inflammatory remedies which offer a safer alternative treatment for pain relief, especially for long-term use replacing the conventional NSAIDs medicines.

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Section: Anti-inflammatory Activity Of L Pumila Extractssupporting

confidence: 89%

Anti-inflammatory Activity of Polyphenols from Labisia pumila Leaves Extract

Syed Hassan,

Hasham,

Hashim

et al. 2024

Mal. J. Fund. Appl. Sci.

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“…Cytotoxicity testing in B16F1 melanoma cells indicated that the extract was safe at ≤ 100 µg/mL. Cellular melanin levels following treatment with 10, 50, and 100 µg/mL extract were 175.08 % ± 7.42 %, 79.96 % ± 3.51 %, and 46.30 % ± 8.81 %, respectively, of the control level, with the inhibitory action due to TYR and MITF suppression [62].…”

Section: Enzyme Inhibition Cell Culturementioning

confidence: 96%

Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Kanlayavattanakul

Lourith

2018

Planta Med

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Skin hyperpigmentation is caused by several factors that upregulate melanogenesis. Plants and natural products with skin-whitening effects are gaining interest among consumers and researchers because they are perceived to be milder, safer, and healthier than synthetic alternatives. This review extensively summarizes the status of plants and natural products currently used in skin-whitening cosmetics as well as potential candidates for future use, because the scope of natural choices for efficient treatment of skin hyperpigmentation is rapidly widening. Biological activities of plants and natural extracts are therefore available for cosmetic formulators and dermatologists interested in naturally derived ingredients for skin hyperpigmentation treatment and in accordance with the consumers' preferences and expectations upon natural cosmetic products.

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“…The expression of N-cadherin, MMP-9, and STAT-3 signaling pathways is suppressed by quercetin, which may have the potential to limit epithelial-mesenchymal transition (EMT), invasion, and metastasis in PANC-1 cells [191]. Rhus verniciflua Stokes has been extensively utilized in traditional Eastern Asian medical systems for an extended amount of time [192,193]. It was discovered that downregulation of DR3 in PaC cells decreased the expression of pIkBalpha/beta kinases (pIKKs), MMP9, and XIAP, which are primarily responsible for conferring chemoresistance in PaC cells [194].…”

Section: Herbal Medicines In Vitro Assay To Improve Pdac Therapeutic ...mentioning

confidence: 99%

Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products

Park

2023

IJMS

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Pancreatic ductal adenocarcinoma (PDAC), a highly malignant neoplasm, is classified as one of the most severe and devastating types of cancer. PDAC is a notable malignancy that exhibits a discouraging prognosis and a rising occurrence. The interplay between diabetes and pancreatic cancer exhibits a reciprocal causation. The identified metabolic disorder has been observed to possess noteworthy consequences on health outcomes, resulting in elevated rates of morbidity. The principal mechanisms involve the suppression of the immune system, the activation of pancreatic stellate cells (PSCs), and the onset of systemic metabolic disease caused by dysfunction of the islets. From this point forward, it is important to recognize that pancreatic-cancer-related diabetes (PCRD) has the ability to increase the likelihood of developing pancreatic cancer. This highlights the complex relationship that exists between these two physiological states. Therefore, we investigated into the complex domain of PSCs, elucidating their intricate signaling pathways and the profound influence of chemokines on their behavior and final outcome. In order to surmount the obstacle of drug resistance and eliminate PDAC, researchers have undertaken extensive efforts to explore and cultivate novel natural compounds of the next generation. Additional investigation is necessary in order to comprehensively comprehend the effect of PCRD-mediated apoptosis on the progression and onset of PDAC through the utilization of natural compounds. This study aims to examine the potential anticancer properties of natural compounds in individuals with diabetes who are undergoing chemotherapy, targeted therapy, or immunotherapy. It is anticipated that these compounds will exhibit increased potency and possess enhanced pharmacological benefits. According to our research findings, it is indicated that naturally derived chemical compounds hold potential in the development of PDAC therapies that are both safe and efficacious.

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The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin

Cited by 6 publications

References 42 publications

Anti-inflammatory Activity of Polyphenols from Labisia pumila Leaves Extract

Anti-inflammatory Activity of Polyphenols from Labisia pumila Leaves Extract

Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products

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