The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study

Ding, Kaixi; Jiang, Wei; Zhangwang, Juejue; Li, Jian; Lei, Ming

doi:10.1007/s00223-023-01178-w

Calcif Tissue Int

2024

DOI: 10.1007/s00223-023-01178-w

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The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study

Kaixi Ding,

Wei Jiang,

Juejue Zhangwang

et al.

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2024

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Cited by 1 publication

References 29 publications

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Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study

Zhang,

Zhou,

Guan

2024

Twin Res Hum Genet

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Immunity activation and inflammation are the main characteristics of rheumatoid arthritis and clonal hematopoiesis. However, it remains unclear whether rheumatoid arthritis increase the risk of clonal hematopoiesis. Here, a Mendelian randomization (MR) analysis was conduct to explore the causal effects of rheumatoid arthritis on clonal hematopoiesis. Summary statistics data of rheumatoid arthritis (13,838 cases and 33,742 controls) and clonal hematopoiesis (10,203 cases and 173,918 controls) derived from a genomewide association study were selected to analyze. We selected inverse-variance weighted, MR-Egger, weighted median, simple mode, and weighted mode to evaluate the causal effect of rheumatoid arthritis on clonal hematopoiesis. The two-sample MR analysis suggested a strong causal relationship between rheumatoid arthritis and clonal hematopoiesis by inverse-variance weighted (OR = 1.002311673, 95% CI [1.000110757, 1.004517433], p = .039706) and weighted median (OR = 1.002311673, 95% CI [1.000110757, 1.004517433], p = .039518447) methods. No significant pleiotropy or heterogeneity was found in the sensitivity analysis. These results supported a potentially causal relationship between rheumatoid arthritis and clonal hematopoiesis, and the exposure of rheumatoid arthritis increased the risks of clonal hematopoiesis. Our findings highlight the importance of how chronic inflammation and immune activation induced rheumatoid arthritis enhances the risks of clonal hematopoiesis, and that early intervention with rheumatoid arthritis patients might reduce the clonal hematopoiesis risks in rheumatoid arthritis patients. Moreover, our study provides clues for prediction of risk factors and potential mechanisms of clonal hematopoiesis.

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Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study

Zhang,

Zhou,

Guan

2024

Twin Res Hum Genet

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The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study

Cited by 1 publication

References 29 publications

Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study

Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study

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