The effect of residual water on antacid properties of sucralfate gel dried by microwaves

Abstract

The aim of this work was to study the acid neutralization characteristics of microwave-dried sucralfate gel in relation to the water content and physical structure of the substance. Several dried sucralfate gels were compared with humid sucralfate gel and sucralfate nongel powder in terms of neutralization rate and buffering capacity. Humid sucralfate gel and microwave-dried gel exhibited antacid effectiveness. In particular, the neutralization rate of dried gel powders was inversely related to the water content: as the water content of dried powders decreased, the acid reaction rate linearly increased. The relationship was due to the different morphology of dried sucralfate gels. In fact, the porosity of the dried samples increased with the water reduction. However, the acid neutralization equivalent revealed that the dried sucralfate gel became more resistant to acid attack in the case of water content below 42%. Then, the microwave drying procedure had the opposite effect on the reactivity of the aluminum hydroxide component of dried sucralfate gel powders, since the rate of the reaction increased whereas the buffering capacity decreased as the amount of water was reduced.

Design of Alginate-Based Aerogel for Nonsteroidal Anti-Inflammatory Drugs Controlled Delivery Systems Using Prilling and Supercritical-Assisted Drying

“…The images were taken at the same magnification. A scanned area of the SEM image, a box of 200 μm width and 200 μm length, was analyzed by Image J software using the algorithm known as the “box counting method.”34,35 The analysis was carried out on five different area sections for each bead image considered and a mean fractal descriptor was obtained. The analysis was repeated on at least 10 beads for each batch.…”

Insights into the Structure of Sucralfate by Advanced Solid- and Liquid-State NMR

“…25 It has been reported that the presence of water can slow down the acidneutralizing capacity of sucralfate. 12 27 Al MAS spectra clearly revealed different Al environments in the two forms (Figure 2a,b). Interestingly, unlike Form II, complete Al release does not occur in Form I.…”

“…The acid neutralization behavior of sucralfate gel in relation to the water content and physical structure was evaluated by Gainotti et al On comparing the neutralization rate of different dried sucralfate gels with humid gel and sucralfate non gel powder, it was found that the dried product shows a higher acid neutralization rate since its surface is in direct contact with the acid. 12 Sugar-free sucralfate chewable tablets were successfully formulated by Rajesh et al, and its acid neutralizing capacity was measured by NaOH titration. 13 There is no consensus in the literature about the acid neutralization behavior of sucralfate, where sucralfate interacts with acid and releases sucrose octasulfate and aluminum ions.…”

“…A limited number of reports are found in the literature on the mode of action of sucralfate in the acidic environment as in the stomach. The acid neutralization behavior of sucralfate gel in relation to the water content and physical structure was evaluated by Gainotti et al On comparing the neutralization rate of different dried sucralfate gels with humid gel and sucralfate non gel powder, it was found that the dried product shows a higher acid neutralization rate since its surface is in direct contact with the acid . Sugar-free sucralfate chewable tablets were successfully formulated by Rajesh et al, and its acid neutralizing capacity was measured by NaOH titration .…”

NSAIDS: Design and Development of Innovative Oral Delivery Systems

“…Several benefits can be obtained from technologies such as short processing time, better products uniformity and yields, energy saving, reduced production costs, as well as the ability to confer unique structural characteristics to the end materials. Recently, MW heating technology has been shown to be useful in the design of single-unit dosage forms such as solid dispersion, granules, and tablets [75][76][77][78]. Moreover, in the case of dextran-based formulations (i.e., alginate, pectin, and chitosan), MW irradiation leads to obtain xerogels with modified drug release properties due to the extent of polymer cross-linking and drug-excipient complexation [79,80].…”