NSAIDS: Design and Development of Innovative Oral Delivery Systems

Abstract

Recently, different technologies have been used to transform active pharmaceutical ingredients (APIs) into new dosage forms. Engineered drug delivery systems may modify biopharmaceutical properties of the API achieving either immediate or delayed release according to specific therapeutic needs. Particularly, preprogrammed release of oral formulations delivering the drug at expected times may be useful in chronotherapy of early morning pathologies. The conventional approach when dealing with such diseases is to administer NSAIDs two to three times daily. This approach does not allow to fit drug release with symptoms onset resulting in inefficient therapy and poor patient compliance. NSAIDs may be very effective if administered at least 4-6 h before the pain reaches its peak in the early morning. The solution could be to design delayed drug delivery systems allowing one administration before going to sleep acting in the early morning. This chapter highlights new approaches in developing controlled delivery systems of NSAIDs potentially useful to treat both acute and chronic inflammation. The chapter illustrates the versatility of laminar jet break-up technology (prilling) to produce gel beads able to control rate and time of drug delivery. A special focus will be on particle-engineering strategies, i.e., prilling and prilling technique in tandem with microwave or supercritical fluid-assisted drying.

Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems

“…The prilling process (laminar jet break-up) has been widely used to produce crosslinked alginate micro-particles (gel-beads) acting as controlled drug delivery systems [8,9]. Prilling is a mild and scalable microencapsulation technique working essentially through two steps: the breaking apart of a laminar jet of alginate solution into a row of mono-sized drops through a vibrating nozzle and the successive drops' ionotropic gelling in a solution of cations acting as crosslinkers.…”

Xây Dựng Công Thức Bào Chế Viên Nang Chứa Mộc Miết Tử

“…-Đánh giá khối lượng riêng biểu kiến bằng phương pháp gõ đến thể tích không đổi [11]: Trơn chảy kém -Độ rã: thử theo DĐVN V, phụ lục 11.6. Yêu cầu thời gian rã của viên không quá 30 phút.…”

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

“…Hydrogel particles can be dried using several techniques such as conventional, dielectric, freeze or supercritical drying, each one with a significant impact on the physicochemical and textural properties of the final dried beads [169]. Phenomena such as modifications of the highly interconnected hydrogel network, solute migration, polymorphism, damages by overheating and many other effects can occur [170]. Therefore, the choice of the drying method represents one of the critical step on the pathway to the production of PbHPs.…”