The effect of repetitive transcranial magnetic stimulation on cognitive impairment in Parkinson’s disease with dementia: Pilot study

Khedr, Eman M.; Mohamed, Khaled O.; Ali, Asem; Hasan, Asmaa M

doi:10.3233/rnn-190956

Cited by 19 publications

(31 citation statements)

References 51 publications

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“…Recent trials are in agreement about the motor efficacy of the technique, as measured by means of UPDRS-III, including two positive trials with 20 Hz rTMS on M1 17 , one with 10 Hz on the SMA 18 , and two comparative trials. The first of these comparative trials showed longer-lasting efficacy of 20 Hz rTMS on M1, compared with 1 Hz 19 , while the other showed improvement with 5 Hz only on the pre-SMA, compared with M1 20 .…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 67%

“…Like non-PD depression patients, left DLPFC stimulation was found to be effective for the improvement of depression scores (SMD 1.64), which was consistent with a previous meta-analysis 23 . Lastly, a recent meta-analysis found that rTMS on the M1 or PFC did not have any significant effect on cognition 24 , while minor cognitive improvement was observed in a later study using 20 Hz rTMS on bilateral M1, in PD patients with dementia 17 . No study on TMS and PD has described any serious side effects.…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 94%

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Use of non-invasive stimulation in movement disorders: a critical review

Godeiro-Júnior

França

Carra

et al. 2021

Arq. Neuro-Psiquiatr.

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Background: Noninvasive stimulation has been widely used in the past 30 years to study and treat a large number of neurological diseases, including movement disorders. Objective: In this critical review, we illustrate the rationale for use of these techniques in movement disorders and summarize the best medical evidence based on the main clinical trials performed to date. Methods: A nationally representative group of experts performed a comprehensive review of the literature in order to analyze the key clinical decision-making factors driving transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in movement disorders. Classes of evidence and recommendations were described for each disease. Results: Despite unavoidable heterogeneities and low effect size, TMS is likely to be effective for treating motor symptoms and depression in Parkinson’s disease (PD). The efficacy in other movement disorders is unclear. TMS is possibly effective for focal hand dystonia, essential tremor and cerebellar ataxia. Additionally, it is likely to be ineffective in reducing tics in Tourette syndrome. Lastly, tDCS is likely to be effective in improving gait in PD. Conclusions: There is encouraging evidence for the use of noninvasive stimulation on a subset of symptoms in selected movement disorders, although the means to optimize protocols for improving positive outcomes in routine clinical practice remain undetermined. Similarly, the best stimulation paradigms and responder profile need to be investigated in large clinical trials with established therapeutic and assessment paradigms that could also allow genuine long-term benefits to be determined.

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Section: Transcranial Magnetic Stimulationmentioning

confidence: 67%

Section: Transcranial Magnetic Stimulationmentioning

confidence: 94%

Use of non-invasive stimulation in movement disorders: a critical review

Godeiro-Júnior

França

Carra

et al. 2021

Arq. Neuro-Psiquiatr.

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“…Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a potential treatment for cognitive impairment in Parkinson's disease (PD), with effects that appear to be additive to dopaminergic medicines ( 73 ). While it is difficult to pinpoint the exact role of pathological neural oscillations in certain aspects of motor and cognitive function, current research clearly suggests that these pathological oscillations interact and contribute to the motor and cognitive deficits seen in Parkinson's disease ( 74 ).…”

Section: Tms In Movement Disordersmentioning

confidence: 99%

“…While it is difficult to pinpoint the exact role of pathological neural oscillations in certain aspects of motor and cognitive function, current research clearly suggests that these pathological oscillations interact and contribute to the motor and cognitive deficits seen in Parkinson's disease ( 74 ). Another study found that repetitive transcranial magnetic stimulation (rTMS) over (motor region) M1 is beneficial for motor function and may have a slight favorable effect on cognition ( 73 ). The efficacy of TMS on depression and cognition in Parkinson's disease has yielded promising preliminary results.…”

Section: Tms In Movement Disordersmentioning

confidence: 99%

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

2022

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Transcranial Magnetic Stimulation (TMS) has widespread use in research and clinical application. For psychiatric applications, such as depression or OCD, repetitive TMS protocols (rTMS) are an established and globally applied treatment option. While promising, rTMS is not yet as common in treating neurological diseases, except for neurorehabilitation after (motor) stroke and neuropathic pain treatment. This may soon change. New clinical studies testing the potential of rTMS in various other neurological conditions appear at a rapid pace. This can prove challenging for both practitioners and clinical researchers. Although most of these neurological applications have not yet received the same level of scientific/empirical scrutiny as motor stroke and neuropathic pain, the results are encouraging, opening new doors for TMS in neurology. We here review the latest clinical evidence for rTMS in pioneering neurological applications including movement disorders, Alzheimer's disease/mild cognitive impairment, epilepsy, multiple sclerosis, and disorders of consciousness.

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“…Finally, besides those analyzed in the aforementioned meta-analysis, another recent study explored rTMS in PDD [75]. The researchers randomized 33 PDD patients to receive either HF-rTMS (20 Hz, 90% RMT) (18 patients) over the hand area of both primary motor cortices for two weeks (5 days/week), or sham (15 patients).…”

Section: Lewy Body Dementiamentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation in the Treatment of Alzheimer’s Disease and Other Dementias

et al. 2021

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Dementia is a debilitating impairment of cognitive functions that affects millions of people worldwide. There are several diseases belonging to the dementia spectrum, most prominently Alzheimer’s disease (AD), vascular dementia (VD), Lewy body dementia (LBD) and frontotemporal dementia (FTD). Repetitive transcranial magnetic stimulation (rTMS) is a safe, non-invasive form of brain stimulation that utilizes a magnetic coil to generate an electrical field and induce numerous changes in the brain. It is considered efficacious for the treatment of various neuropsychiatric disorders. In this paper, we review the available studies involving rTMS in the treatment of these dementia types. The majority of studies have involved AD and shown beneficial effects, either as a standalone, or as an add-on to standard-of-care pharmacological treatment and cognitive training. The dorsolateral prefrontal cortex seems to hold a central position in the applied protocols, but several parameters still need to be defined. In addition, rTMS has shown potential in mild cognitive impairment as well. Regarding the remaining dementias, research is still at preliminary phases, and large, randomized studies are currently lacking.

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The effect of repetitive transcranial magnetic stimulation on cognitive impairment in Parkinson’s disease with dementia: Pilot study

Cited by 19 publications

References 51 publications

Use of non-invasive stimulation in movement disorders: a critical review

Use of non-invasive stimulation in movement disorders: a critical review

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

Repetitive Transcranial Magnetic Stimulation in the Treatment of Alzheimer’s Disease and Other Dementias

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