The Effect of Recombinant Human Bone Morphogenetic Protein‐4 on the Osteoblastic Differentiation of Mouse Calvarial Cells Affected by Porphyromonas gingivalis

Abstract

Our results suggest that supplemental BMPs would be beneficial for improved treatment of osseous defects, although their biologic effect might be significantly reduced by periodontopathic bacteria.

Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers

“…The factor within the matrix responsible for this effect was later named BMP. After recombinant human BMP(rhBMP) was successfully synthesized by Wozney et al [2] in 1988, a number of studies have demonstrated the biologic activities of rhBMPs which include the induction of ectopic cartilage and bone formation at implanted sites in vivo [2][3][4] and the stimulation of osteoblastic phenotype expression, such as alkaline phosphatase (ALP), type I collagen, osteocalcin (OC), osteopontin (OP) and bone sialoprotein during the course of osteoblastic differentiation in various types of cells in vitro [5][6][7][8][9].…”

The effect of a fibrin-fibronectin/β-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects

“…Recombinant human bone morphogenetic proteins (rhBMPs) have been shown to possess significant osteoinductive potential [1][2][3][4][5][6], but in order to take advantage of this effect for tissue engineering, carrier systems are essential [7,8].…”

Effect of Recombinant Human Bone Morphogenetic Protein‐2, ‐4, and ‐7 on Bone Formation in Rat Calvarial Defects

“…These studies included the induction of ectopic cartilage and bone formation at implanted sites in vivo [2][3][4] and the stimulation of osteoblastic phenotype expression during the course of osteoblastic differentiation in various cell types in vitro. [5][6][7][8][9] Currently, >20 BMPs have been identified, and several, including BMP-2, -4, -5, -6, and -7, have been shown to have significant osteoinductive activity. [6][7][8][9][10][11][12][13][14] Accordingly, there have been many trials using rhBMPs for bone tissue engineering.…”