Effect of Recombinant Human Bone Morphogenetic Protein‐2, ‐4, and ‐7 on Bone Formation in Rat Calvarial Defects

Hyun, Seungjoon; Han, Dong Woo; Choi, Seong Ho; Chai, Jung‐Kiu; Cho, Kyoo-Sung; Kim, Chong Kwan; Kim, Chang Sung

doi:10.1902/jop.2005.76.10.1667

Cited by 55 publications

(51 citation statements)

References 36 publications

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“…In most cases of bone treated by 30 µg rhBMP-2, the dose was too high, causing new bone area to overgrow. The minimum effective dose of rhBMP-2 in rat femur bone healing was difficult to predict because the amounts of rhBMP-2 used in rat studies with collagen as a carrier have ranged from 0.5 to 200 µg [2,10,[17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Reindeer bone extract can heal the critical-size rat femur defect

Tölli

Kujala

Jämsä

et al. 2010

International Orthopaedics (SICOT)

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Bone extract from reindeer induces new ectopic bone formation (BF) in muscle pouches, but its feasibility in experimental bone lesions has not been evaluated. We investigated the effects of implants, containing 2, 5, 15, 20 or 50 mg of reindeer bone extract in a collagen carrier, on the healing of 8-mm femur defects in 78 rats. We used 30 µg of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a collagen carrier, collagen and untreated defects as controls. Bone healing was evaluated with radiographs, peripheral quantitative computed tomography (pQCT), biomechanics and histology. In comparison with empty defects, the groups receiving bone extracts showed more BF at three weeks and had better bone union (BU), larger mean cross-sectional bone area at the defect site in groups receiving higher doses of extract, showed greater torsional stiffness of the bones and higher maximum breaking load of bones at six weeks. In comparison to all other groups, in the rhBMP-2 group, BF and BU were best at the three-and six-week follow-up, bone area was largest and mechanical test results were best. Although rhBMP-2 is superior for new bone regeneration, native reindeer bone extract is also effective in the six-week follow-up period.

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Section: Discussionmentioning

confidence: 99%

Reindeer bone extract can heal the critical-size rat femur defect

Tölli

Kujala

Jämsä

et al. 2010

International Orthopaedics (SICOT)

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“…The ideal scaffold materials should be resorbed over time to allow cell infiltration and extracellular matrix deposition for new bone formation, while maintaining its osteoconductive properties until they are no longer required [17][18][19] . So far, ACS has been extensively used as an appropriate carrier for BMPs in bone reconstructive surgery 2,3,20,21) . Conversely, Bergeron et al recently reported that the injection of a chitosan-based BMP-9 gel induced ectopic bone formation, whereas collagen-based BMP-9 gel injection failed to promote ectopic ossification in mouse quadriceps 22) .…”

Section: Introductionmentioning

confidence: 99%

Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects

et al. 2016

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The aim of this study was to examine the effects of recombinant human BMP-9 (rhBMP-9) with chitosan sponge (ChiS) or absorbable collagen sponge (ACS) on bone formation in rat calvarial defects. The defects were treated by one of the following implantations: ChiS, rhBMP-9/ChiS, ACS, rhBMP-9/ACS and no implantation. The animals were euthanized at 8 weeks for histological evaluation. The percentage of defect closure (DC) in the rhBMP-9/ACS group was significantly greater than that in the ACS group. The rhBMP-9/ ACS group demonstrated the highest level of DC among all the groups. The newly formed bone area (NBA) and NBA/total area in the ChiS-implanted groups and in the rhBMP-9/ACS group were significantly greater compared with those in the ACS group. It can be concluded that rhBMP-9/ACS has a potential to induce bone formation in rat calvarial defects. Further studies are required to elucidate the mechanism of bone formation induced by rhBMP-9.

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“…The number of materials used as carriers to accomplish delivery of BMPs at the site of implantation is huge and includes mineralized scaffolds [e.g. [8][9][10][11][12], metals [13], polymers [14,15], silk [16,17] and collagen [18][19][20][21]. However, most of these materials are unable to maintain a defined shape after implantation because they are either too soft or difficult to stabilize.…”

Section: Introductionmentioning

confidence: 99%

Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid—An experimental study in rats

et al. 2008

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Effect of Recombinant Human Bone Morphogenetic Protein‐2, ‐4, and ‐7 on Bone Formation in Rat Calvarial Defects

Abstract: Within the rhBMP types used, rhBMP concentration, and the observation interval, there appears to be no specific differences in bone regenerative potential. All rhBMPs used in this study may be considered effective factors for inducing bone formation.

Cited by 55 publications

References 36 publications

Reindeer bone extract can heal the critical-size rat femur defect

Reindeer bone extract can heal the critical-size rat femur defect

Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects

Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid—An experimental study in rats

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