The effect of real-time polymerase chain reaction cycle threshold values on perinatal outcomes of pregnant women with COVID-19

Anuk, Ali Taner; Erol, Seyit Ahmet; Keskin, Hüseyin Levent; Altınboğa, Orhan; Yakıştıran, Betül; Aydoğan, Sibel; Unlu, Serpil; Eyı, Elif Gül Yapar; Tayman, Cüneyt; Dinç, Bedia; Şahın, Dilek; Tekın, Özlem Moraloğlu

doi:10.1080/14767058.2021.1900105

Cited by 6 publications

(8 citation statements)

References 27 publications

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“…We also aimed to quantify the association between COVID-19 infection during pregnancy and maternal characteristics, adverse outcomes, and Ct values. In the current study, the C T value of less than 37.5 was interpreted as positive for SARS-CoV-2 RNA and further categorized as high C T (>30), medium C T (25)(26)(27)(28)(29)(30), or low C T (<25), according to cut-off points used in previous studies [19]. However, this study found no significant association between clinical symptoms and C T values, likely because most patients had mild or no symptoms.…”

Section: Discussionmentioning

confidence: 54%

“…In contrast, work from Tanacan and cols. showed increased adverse obstetric outcomes and more extended hospital stays with lower C T s (<22.9) [ 26 ]. The difference between this work and our results could probably be explained by the population under study, which included pregnant women with severe to moderate symptoms compared to only mild symptoms or asymptomatic patients in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Lower C T values may be related to a higher viral load, although there is no perfect correlation [17,18], and this is the reason why C T should not be considered equivalent to viral load. In this study, a C T value <37.5 was deemed to be positive, and C T counts were categorized as high (C T > 30), medium (C T of [25][26][27][28][29][30], or low (C T < 25) according to cut-off points used in previous studies [19].…”

Section: T Valuesmentioning

confidence: 99%

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COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

Laresgoiti-Servitje

Cardona–Pérez

Hernández-Cruz

et al. 2021

Viruses

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(1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (CT) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and CT values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between CT values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low CTs (<25; p < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or CT values (p < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: T Valuesmentioning

confidence: 99%

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COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

Laresgoiti-Servitje

Cardona–Pérez

Hernández-Cruz

et al. 2021

Viruses

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“…From these data it appears that symptomatic pediatric patients were more likely to have higher viral loads in the upper respiratory tract than their asymptomatic counterparts; whereas, there was no significant difference in viral load among maternal PUI and SCRN patients, a finding consistent with some previous studies [ 10–14 ]. Other studies have demonstrated a correlation between high maternal viral load and an increased rate of obstetric complications [ 15 ]. While we did assess the Ct values in this cohort and found that there was no statistical difference between symptomatic and asymptomatic pregnant women, it was beyond the scope of this paper to investigate clinical outcomes in this group.…”

Section: Discussionmentioning

confidence: 99%

Performance of Six SARS-CoV-2 Rna Detection Systems in Symptomatic and Asymptomatic Pediatric and Maternal Patients

et al. 2021

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Aim: This study evaluated the real-world performance of six test systems for detection of SARS-CoV-2 in 138 pediatric and 110 adult maternal patients. Materials & methods: Nasopharyngeal swabs were tested directly using the Aptima™ SARS-CoV-2 (Aptima) and Simplexa™ COVID-19 Direct (Simplexa), and with Altona RealStar® RT-PCR and CDC RT-PCR with nucleic acid extracted on the Roche® MagNA Pure 96 (Altona-MP96) or bioMérieux EMAG® (Altona-EMAG). Results/Conclusion: Overall percent-positive and percent-negative agreements among the six test systems were, respectively: Aptima: 94.8 and 100%; Altona-MP96: 96.5 and 99.3%; CDC-MP96: 100 and 99.3%; Altona-EMAG: 86.1 and 100%; CDC-EMAG: 98.2 and 100%; Simplexa: 87 and 99.2%. The six test systems showed agreement ranging from 92.7 (κ = 0.85) to 98.8% (κ = 0.98).

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“…These studies indicated that severe/critic disease was associated with increased rates of preterm and cesarean deliveries mostly due to the worsening in maternal health condition [70,71]. Moreover a higher rate of obstetric complications was observed in cases with higher viral load [72].…”

Section: Obstetric and Neonatal Complicationsmentioning

confidence: 99%

Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

Şahın¹,

Webster²,

Tekın³

2021

Turk J Med Sci

Self Cite

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Coronavirus disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized by significant changes in cardiovascular, respiratory, endocrine and immunological systems, there are concerns on issues like the course of disease in pregnant women, safety of medications, route of delivery and risk of obstetric complications. The aim of this review is to summarize the current literature in the management of pregnant women during the COVID-19 pandemic. Although more than 90% of pregnant women with COVID-19 recover without serious morbidity, rapid deterioration of disease and higher rates of obstetric complications may be observed. The risk of vertical transmission has not been clearly revealed, yet. Decreasing the number of prenatal visits, shortening the time allocated for the examinations, active use of telemedicine services, limiting the number of persons in health-care settings, combining prenatal tests in the same visit, restricting visitors during the visits, providing a safe environment in health-care facilities, strict hygene control and providing personal protective equipment during the visits are the main strategies to control the spread of disease according to current guidelines. Although new medication alternatives are being proposed every day for the treatment of COVID-19, our knowledge about the use of most of these drugs in pregnancy is limited. Preliminary results are promising for the administration of SARS-CoV-2 vaccines in the pregnant population. Timing of delivery should be decided based on maternal health condition, accompanying obstetric complications and gestational age. Cesarean delivery should be performed for obstetric indications. Breast feeding should be encouraged as long as necessary precautions for viral transmission are

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The effect of real-time polymerase chain reaction cycle threshold values on perinatal outcomes of pregnant women with COVID-19

Cited by 6 publications

References 27 publications

COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

Performance of Six SARS-CoV-2 Rna Detection Systems in Symptomatic and Asymptomatic Pediatric and Maternal Patients

Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

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