The effect of purslane seeds on biomarkers of oxidative stress in diabetic patients: A randomized controlled cross-over clinical trial

Abstract

Background:This study was designed to examine the effects of purslane seeds on biomarkers of oxidative stress in type 2 diabetic patients.Methods:This cross-over randomized controlled clinical trial was conducted on 40 patients with type 2 diabetes. Participants were randomly assigned to receive either 10 g/day purslane seeds with 240 cc low-fat yogurt (intervention group) or only 240 cc low-fat yogurt (as a control group) for 5 weeks. After a 2-week washout period, subjects were moved to the alternate arm for an additional 5 weeks. At baseline and end of each study phase, fasting blood samples were collected to quantify biomarkers of oxidative stress.Results:We observed a slight decrease in plasma total antioxidant capacity in both groups, however, between-group changes were not significant (−2.67 vs. −2.95 μg/dL, P = 0.94). Plasma malondialdehyde in purslane group increased slightly, however, we observed no significant effect in the control group (1.62 vs. −0.47 μg/dL, P = 0.58). Although both groups had a slight reduction in plasma oxidized low-density lipoprotein (ox-LDL), we failed to find any significant effect of purslane on plasma ox-LDL (−1.06 vs. −1.71 μg/dL, P = 0.85).Conclusions:This cross-over clinical trial revealed that consumption of purslane seeds for 5 weeks in type 2 diabetic patients did not result in improved oxidative stress.

Purslane (Portulaca oleracea) Seed Consumption And Aerobic Training Improves Biomarkers Associated with Atherosclerosis in Women with Type 2 Diabetes (T2D)

“…Hence, aerobic training is beneficial for patients with T2D404246. The results obtained from our study also highlights the positive effects of purslane seed consumption on TG, LDL, cholesterol and HDL levels, which is consistent with earlier reports in T2D of Yemeni and Iranian patients531.…”

“…Several studies have indicated purslane extract as a factor in lowering blood sugar, triglycerides, total cholesterol, high-density-lipoprotein (HDL), low-density-lipoprotein (LDL) and body weight in diabetic rat and mice2728. Moreover, consumption of purslane seeds alongside 8 weeks of resistance training by women with T2D, improved indicators associated with liver damage29, proxidant and antioxidant balance30 and blood pressure31. It also prevented exercise-induced oxidative stress30.…”

Hypoglycemic and pancreatic protective effects of Portulaca oleracea extract in alloxan induced diabetic rats

“…Thus, the excessive breakdown of tissue proteins due to diminished insulin response as well as the unavailability of carbohydrate for energy metabolism in diabetes mellitus results in decreased body weight. Interestingly, P oleracea administration to control rats caused a significant reduction in body weight, an effect that was resembled in the experimental research of Bai et al [55] as well as clinical study of Esmaillzadeh et al [56]. …”

The clinical effects of purslane (Portulaca oleracea) seeds on metabolic profiles in patients with nonalcoholic fatty liver disease: A randomized controlled clinical trial

“…Participants' characteristics were heterogeneous as well. Most of the studies were performed on patients with type 2 diabetes (Dehghan et al, 2016;Esmaillzadeh et al, 2015;Farzanegi, 2014;Wainstein et al, 2016). On the other hand, we examined the effect of purslane consumption on NAFLD patients.…”