Purslane (Portulaca oleracea) Seed Consumption And Aerobic Training Improves Biomarkers Associated with Atherosclerosis in Women with Type 2 Diabetes (T2D)

Abstract

The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers to purslane seed consumption and aerobic training in women with T2D. 196 women with T2D were assigned into; (1) placebo (PL), (2) aerobic training+placebo (AT + PL), 3) purslane seeds (PS), aerobic training+purslane seeds (AT + PS). The training program and purslane seeds consumption (2.5 g lunch and 5 g dinner) were carried out for 16 weeks. The components of purslane seed were identified and quantified by GC–MS. Blood samples were withdrawn via venipuncture to examine blood glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, triglycerides (TG), creatinine, urea, uric acid, NF-κB, GLP1, GLP1R, TIMP-1, MMP2, MMP9, CRP, CST3, and CTSS expressions. Blood glucose, LDL, cholesterol, TG, creatinine, urea, and uric acid levels in the (P), (AT), and (AT + PS) groups were significantly decreased compared to the pre-experimental levels or the placebo group, while HDL, significantly increased. Furthermore, the protein and mRNA levels of NF-κB, TIMP-1, MMP2 &9, CRP, CST3, and CTSS in the (P), (AT), (AT + PS) significantly decreased compared to pre-experimental or the placebo group, while level of GLP1 and GLP1-R increased drastically. Findings suggest that purslane seed consumption alongside exercising could improve atherosclerosis plaque biomarkers through synergistically mechanisms in T2D.

The clinical effects of purslane (Portulaca oleracea) seeds on metabolic profiles in patients with nonalcoholic fatty liver disease: A randomized controlled clinical trial

“…Participants' characteristics were heterogeneous as well. Most of the studies were performed on patients with type 2 diabetes (Dehghan et al, 2016;Esmaillzadeh et al, 2015;Farzanegi, 2014;Wainstein et al, 2016). On the other hand, we examined the effect of purslane consumption on NAFLD patients.…”

Effect of purslane on blood lipids and glucose: A systematic review and meta‐analysis of randomized controlled trials

“…In the two studies in which purslane was applied in capsule form, the supplementation dosage were 0.6 mg (Bedakhanian et al, ) and 0.18 mg (Wainstein et al, ) daily. Two studies (Dehghan et al, ; Farzanegi, ) involved solely females, one study only males (Bedakhanian et al, ), and the three remaining studies (Esmaillzadeh et al, ; Najafabadi et al, ; Wainstein et al, ) enrolled both genders as participants. Four studies (Dehghan et al, ; Esmaillzadeh et al, ; Farzanegi, ; Wainstein et al, ) included subjects with type 2 diabetes, one study (Bedakhanian et al, ) had subjects with metabolic syndrome, and one (Najafabadi et al, ) included nonalcoholic fatty liver patients.…”

“…Two studies (Dehghan et al, ; Farzanegi, ) involved solely females, one study only males (Bedakhanian et al, ), and the three remaining studies (Esmaillzadeh et al, ; Najafabadi et al, ; Wainstein et al, ) enrolled both genders as participants. Four studies (Dehghan et al, ; Esmaillzadeh et al, ; Farzanegi, ; Wainstein et al, ) included subjects with type 2 diabetes, one study (Bedakhanian et al, ) had subjects with metabolic syndrome, and one (Najafabadi et al, ) included nonalcoholic fatty liver patients. Five trials (Bedakhanian et al, ; Dehghan et al, ; Farzanegi, ; Najafabadi et al, ; Wainstein et al, ) used a parallel RCT design, and one study (Esmaillzadeh et al, ) used a cross‐over methodology.…”

“…Four studies (Dehghan et al, ; Esmaillzadeh et al, ; Farzanegi, ; Wainstein et al, ) included subjects with type 2 diabetes, one study (Bedakhanian et al, ) had subjects with metabolic syndrome, and one (Najafabadi et al, ) included nonalcoholic fatty liver patients. Five trials (Bedakhanian et al, ; Dehghan et al, ; Farzanegi, ; Najafabadi et al, ; Wainstein et al, ) used a parallel RCT design, and one study (Esmaillzadeh et al, ) used a cross‐over methodology. The mean age (year) and body mass index (kg/m 2 ) of participants were nearly 55 years and 29.61, respectively.…”

The Effect of Endurance Training and Purslane Seed Consumption on NF-κB and CRP in the Heart Tissue of Rats Exposed to Oxidative Damage Induced by H2O2

“…In addition, eight weeks of resistance training and aerobic exercise training simultaneously with consumption of purslane seeds by women with type 2 diabetes improved pro-oxidant and antioxidant balance. It also prevented exercise-induced oxidative stress (16), and also had a significant effect on the decrease in NF-κB and CRP (17). A total of 200 g/kg of purslane seed oil consumption for 21 consecutive days significantly increase GP, SOD, and GSH as well as decreased ALP, AST, and LDH in female mice.…”