The Effect of Psychological Distress and Personality Traits on Cognitive Performances and the Risk of Dementia in Patients with Mild Cognitive Impairment

Ramakers, Inez H.G.B.; Honings, Steven; Ponds, Rudolf; Aalten, Pauline; Köhler, Sebastian; Verhey, Frans R.J.; Visser, Pieter Jelle

doi:10.3233/jad-142493

Cited by 19 publications

(16 citation statements)

References 41 publications

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“…Among those with CIND at baseline, we found that conscientiousness was a significant predictor of conversion to dementia, but there was only a non-significant trend for neuroticism. These HRS findings are consistent with a European study of 215 individuals with mild cognitive impairment (Ramakers et al, 2015). The study found that high scores on rigidity, a scale related to conscientiousness, were associated with a lower risk of conversion to dementia.…”

Section: Discussionsupporting

confidence: 92%

Personality traits and risk of cognitive impairment and dementia

Terracciano

Stéphan

Luchetti

et al. 2017

Journal of Psychiatric Research

133

117

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We investigated the association between five factor model personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness) and risk of dementia, cognitive impairment not dementia (CIND), and conversion from CIND to dementia in a large national cohort. Participants from the Health and Retirement Study (N>10,000) completed a personality scale in 2006–2008 and their cognitive status was tracked for up to 8 years using the modified Telephone Interview for Cognitive Status (TICSm). Adjusting for age, sex, education, race, and ethnicity, lower conscientiousness and agreeableness and higher neuroticism were independently associated with increased risk of dementia. These associations remained significant after adjusting for other risk factors for dementia, including income, wealth, smoking, physical inactivity, obesity, diabetes, hypertension, and blood biomarkers. These associations were not modified by age, sex, race, ethnicity, and education, suggesting that the associations of personality with risk of dementia were similar across demographic groups. Neuroticism and conscientiousness were also associated with risk of CIND. Low conscientiousness predicted conversion from CIND to dementia. Using brief assessments of personality and cognition, we found robust evidence that personality is associated with risk of cognitive impairment and dementia in a large national sample.

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Section: Discussionsupporting

confidence: 92%

Personality traits and risk of cognitive impairment and dementia

Terracciano

Stéphan

Luchetti

et al. 2017

Journal of Psychiatric Research

133

117

View full text Add to dashboard Cite

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“…A 10-point increase in neuroticism score values was associated with only 0.15-point decrease in MMSE score at the 10-year follow-up. Paralleling the findings of Ramakers et al [13], the absence of difference in Neuroticism factor and facet scores also concerned the sCON/MCI comparison in our series. It is possible that the very low levels of Neuroticism observed in our sample (compared to age-adjusted normative data) reflect an over-representation of elderly persons with better mental health who are a priori less exposed to the deleterious effect of Neuroticism on cognition.…”

Section: Discussionsupporting

confidence: 72%

“…More recent data challenged the association between high Neuroticism scores and dementia risk. In their 6-year longitudinal study based on the Dutch personality questionnaire, Ramakers et al [13] showed that, although neuroticism scores showed negative correlation with mental speed in MCI, there was no significant association between this variable and MCI conversion to AD. …”

Section: Discussionmentioning

confidence: 99%

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Personality-Related Determinants of Subtle Cognitive Decline in Old Age: A Population-Based Study

Rodriguez

Albanese

Pegna

et al. 2016

Dement Geriatr Cogn Disord Extra

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Background/Aims: Recent studies of cases with mild cognitive impairment (MCI) suggested that besides Alzheimer disease (AD)-related biomarkers, some personality dimensions are associated with progression to AD. To date, there are no studies addressing the psychological determinants of subtle cognitive decline in healthy elderly controls. Methods: 488 community-dwelling healthy controls were assessed with a detailed neuropsychological battery at baseline and an 18-month follow-up. Personality factors and facets were investigated at baseline using the NEO-Personality Inventory-Revised (NEO-PI-R). Upon follow-up, there were 264 stable controls (sCON) and 224 deteriorating controls (dCON). Their personality data were compared to those of the 102 MCI cases using one-way analysis of variance and logistic regression models. Results: Significantly higher scores of Openness factor (as well as Aesthetics, Ideas and Values facets) were found in sCON than in both dCON and MCI cases. The three groups did not differ in the other NEO-PI-R factor and facet scores. Openess factor (and the same facets) was associated with cognitive preservation in healthy controls (OR: 0.72, 95% CI: 0.59, 0.87). Lower scores in the same factor and facets conferred higher risk to have MCI (OR: 0.61, 95% CI: 0.46, 0.79). Conclusion: Higher openness to new experiences and thoughts may be a protective factor against early cognitive decline in brain aging.

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“…The other indirect converging line of evidence relies on the two personality domains that are similar to LOC — neuroticism (similar to external LOC) vs. conscientiousness (similar to internal LOC). Current literature suggests higher neuroticism and lower conscientiousness predict the incidence of dementia and decline in memory function (Caselli, et al, 2016; Duberstein, et al, 2011; Low, et al, 2013; Ramakers, et al, 2015). Thus, LOC and/or similar traits may serve as phenotypic manifestations of either the function or vulnerability to abnormal brain alterations.…”

Section: Discussionmentioning

confidence: 99%

Amygdala functional connectivity is associated with locus of control in the context of cognitive aging

et al. 2017

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Locus of control (LOC) measures the extent to which individuals perceive control over their lives. Those with a more “internal” LOC feel self-sufficient and able to determine important aspects of their own future, while those with a more “external” LOC feel that their lives are governed by events beyond their control. Reduced internal LOC and increased external LOC have been found in cognitive disorders, but the neural substrates of these control perceptions are yet unknown. In the present study, we explored the relationship between amygdala functional connectivity and LOC in 18 amnestic mild cognitive impairment (MCI) and age-, sex-, and education-matched, 22 cognitively healthy controls (HC). Participants completed cognitive challenge tasks (Stroop Word Color task and Dual 1-back) for 20 minutes, and underwent resting-state functional magnetic resonance imaging immediately before and after the tasks. We found significantly lower internal LOC and higher external LOC in the MCI group than the HC group. Compared to HC, MCI group showed significantly stronger positive associations between internal LOC and baseline right amygdala connections (including right middle frontal gyrus and anterior cingulate cortex), and stronger negative associations between internal LOC and change of these right amygdala connections. Across all participants, external LOC explained the relationships between associations of another set of right amygdala connections (including middle cingulate cortex and right superior frontal gyrus), both at baseline and for change, and performance in the cognitive challenge tasks. Our findings indicate that the right amygdala networks might be critical in understanding the neural mechanisms underlying LOC’s role in cognitive aging.

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The Effect of Psychological Distress and Personality Traits on Cognitive Performances and the Risk of Dementia in Patients with Mild Cognitive Impairment

Abstract: Psychological distress negatively affected information processing speed, but was not associated with an increased risk of developing dementia in patients with MCI.

Cited by 19 publications

References 41 publications

Personality traits and risk of cognitive impairment and dementia

Personality traits and risk of cognitive impairment and dementia

Personality-Related Determinants of Subtle Cognitive Decline in Old Age: A Population-Based Study

Amygdala functional connectivity is associated with locus of control in the context of cognitive aging

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