The effect of Propolis and Xylitol chewing gums on salivary Streptococcus mutans count: A clinical trial

Tulsani, S G; Chikkanarasaiah, Nagarathna; Siddaiah, Shakuntala B; Krishnamurthy, Navin Hadadi

doi:10.4103/0970-9290.152182

Cited by 25 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8,9,26,27 Previous studies have reported the strong antimicrobial activity of propolis against several bacteria of the oral m icrobiome, i ncludi ng S. mutans. 1,2,28,29,30,31 As confirmed in our study, propolis and some of its isolated compounds, such as apigenin and tt-farnesol, 11 have been found to display a major effect on microbial virulence (e.g., polysaccharide production and acid tolerance), rather than affecting unspecific or specific microbiome viability, considered a highly desirable quality.…”

Section: Discussionmentioning

confidence: 51%

The anti-caries activity and toxicity of an experimental propolis-containing varnish

et al. 2017

View full text Add to dashboard Cite

Abstract:We investigated the anti-caries effects of an experimental propolis varnish in vivo, and further tested its toxicity against fibroblasts. Fifty-six SPF female Wistar rats were infected with Streptococcus mutans UA159 (SM) and allocated into four groups (n = 14/group): G1, propolis varnish (15%/PV); G2, chitosan varnish (CV/vehicle); G3, gold standard (GS/Duraphat ® ); and G4, untreated. The animals received a single varnish application on their molars and were submitted to a high cariogenic challenge (Diet-2000, 56% sucrose, and 5% sucrose-added water, ad libitum) for 4 weeks. Total cultivable microbiota and SM were counted, and smooth-surface and sulcal caries were scored. PV, CV and GS cytotoxic effects were tested against fibroblasts. The data were analyzed using ANOVA with the TukeyKramer test (p ≤ 0.05). Total microbiota and SM counts did not differ among the treatments (p = 0.78), or in relation to the untreated group (p = 0.52). PV reduced development of smooth-surface enamel caries compared with the untreated group (p = 0.0018), with no significant difference from GS (p = 0.92); however, the PV effects were no longer observed when the dentin was affected. Neither PV nor GS prevented enamel sulcal lesion onset, but GS significantly reduced the severity of dentinal sulcal lesions (p < 0.0001). No significant difference was observed in fibroblast viability between PV and GS (p < 0.0001).In conclusion, PV prevented smooth-surface enamel caries and showed low cell toxicity. Nevertheless, due to the high cariogenic challenge, its effects were not sustained throughout the experiment. Further studies are encouraged to establish a protocol to sustain the long-term anticaries activity of PV in the oral cavity.

show abstract

Section: Discussionmentioning

confidence: 51%

The anti-caries activity and toxicity of an experimental propolis-containing varnish

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Previous research has been established that caries prevalence was not significantly different in boys and girls at an average age ( 17 ). Literature has shown a positive co-relation between baseline S. mutans count and DMFT/dmft ( 18 - 21 ), therefore in our study subjects with DMFT/dmft > 3 were included. Children with special health care needs, systemic diseases, current or recent use of antibiotics and undergoing any dental treatment, orthodontic treatment were excluded from the study since these conditions may alter the microbial load in the oral cavity ( 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of Stevia and Xylitol chewing gum on salivary Streptococcus mutans count – A pilot study

Shinde

Winnier

2020

J Clin Exp Dent

View full text Add to dashboard Cite

Background Stevia is a natural sweetener which is used as sugar substitute. It has been suggested that stevia may be anticariogenic. However, there is limited research in this regard. Hence, the present study was designed to assess reduction in S. mutans in stevia and xylitol chewing gums. The aim of this study is to evaluate the effectiveness of stevia and xylitol chewing gums on salivary Streptococcus mutans count. Material and Methods A randomized triple blinded clinical study with a crossover design included twenty healthy children aged 8-13 years with decayed, missing, and filled teeth (dmft)/DMFT index score ≥ 3. Before the test, unstimulated saliva was collected. Children divided into Group I and II were given Stevia and Xylitol chewing gums respectively. Saliva samples were then collected at 15 min (just after spitting) and after 1 h. The amount of S. mutans in saliva was evaluated using a selective media (TYCSB). The data were subjected to statistical analysis using statistical software IBM SPSS statistics 20.0 (IBM Corporation, Armonk, NY, USA) Results Reduction in S. mutans was seen from baseline to 1 hour in both groups in trial and crossover design though intergroup comparison was not statistically significant. There was reduction seen from baseline to 15 minutes and 15 minutes to 1 hour in xylitol and stevia group both in trial and crossover design which was statistically significant. Conclusions Stevia containing chewing gum is equally effective to Xylitol chewing gum in reducing salivary S. mutans counts. Key words: Stevia, Xylitol , S. mutans.

show abstract

“…Other ingredients incorporated in chewing gum such as chlorhexidine, chitosan, magnolia bark extract, mastic, and propolis were also shown to lower the concentration of planktonic bacteria in saliva compared to a control gum [86,[93][94][95][96][97].…”

Section: Effects On Planktonic Bacteria In Salivamentioning

confidence: 98%

Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare

Weßel

Mei

Maitra³

et al. 2016

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

Evidence for oral-health benefits of chewing gum additives is hard to obtain due to their relatively low concentrations and rapid wash-out. Clinical effects of gum additives are overshadowed by effects of increased mastication and salivation due to the chewing of gum and require daily chewing of gum for prolonged periods of time. Future studies on active ingredients should focus on specifically targeting pathogenic bacteria, whilst leaving the healthy microbiome unaffected.

show abstract

The effect of Propolis and Xylitol chewing gums on salivary Streptococcus mutans count: A clinical trial

Abstract: Propolis chewing gum can be used as an anticariogenic agent in children.

Cited by 25 publications

References 0 publications

The anti-caries activity and toxicity of an experimental propolis-containing varnish

The anti-caries activity and toxicity of an experimental propolis-containing varnish

Comparative evaluation of Stevia and Xylitol chewing gum on salivary Streptococcus mutans count – A pilot study

Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare

Contact Info

Product

Resources

About