The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy

Chia, Yuan-Yi; Lo, Yuan Hung; Liu, K.; Tan, Ping-Heng; Chung, Nien Chun; Ko, Nai-Hua

doi:10.1111/j.1399-6576.2004.00369.x

Cited by 32 publications

(8 citation statements)

References 18 publications

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“…From this drug family, promethazine is most commonly administered for treatment of PONV. The efficacy of the drug for PONV has been demonstrated by randomized controlled trials, 21 and its use is supported by current guidelines. 13 Promethazine targets muscarinic receptors and blocks dopamine receptors as well.…”

Section: Overview Of Antiemetic Agents Currently In Usementioning

confidence: 97%

New pharmacologic findings for the treatment of PONV and PDNV

Kloth

2009

American Journal of Health-System Pharmacy

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Section: Overview Of Antiemetic Agents Currently In Usementioning

confidence: 97%

New pharmacologic findings for the treatment of PONV and PDNV

Kloth

2009

American Journal of Health-System Pharmacy

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“…Compared with placebo, preoperative or postoperative i.v. administration of promethazine 0.1 mg kg -1 reduces the incidence of PONV and the number of patients asking for rescue antiemetic medication [8]. These phenothiazines cause extrapyramidal AEs, such as restlessness and oculogyric crisis [1][2][3].…”

Section: Phenothiazines Butyrophenones Benz-amides and Antihistaminesmentioning

confidence: 99%

“…Phenothiazines (e.g., perphenazine), butyrophenones (e.g., droepridol), benzamides (e.g., metoclopramide) and antihistamines (e.g., cyclizine) are used as traditional antiemetics for preventing PONV after major gynecological surgery in women [6][7][8][9][10][11][12] (Table 1). Phenothiazines exert an antiemetic effect by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) and other areas of the brain (area postrema) [70].…”

Section: Phenothiazines Butyrophenones Benz-amides and Antihistaminesmentioning

confidence: 99%

Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update

Fujii

2011

CDTH

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Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events associated with anesthesia and surgery, with a high incidence after major gynecological surgery (e.g., abdominal hysterectomy). Numerous antiemetics have been studied for the prevention and treatment of PONV after this surgical procedure.Most of the published trials indicate the improved prevention of PONV by avoiding risk factors and/or by using antiemetic therapy in women undergoing major gynecological surgery. Pharmacological approaches include phenothiazines (e.g., perphenazine), butyrophenones (e.g., droperidol), benzamides (e.g., metoclopramide), antihistamines (e.g., cyclizine), proppofol, dexamethasone, ephedrine, serotonin receptor antagonists (e.g., ondansetron, granisetron) and neurokinin-1 receptor antagonists (e.g., aprepitant). None of the currently available antiemetics is entirely effective, perhaps because most of them act through the blockade of one type of receptor. There is a possibility that combined antiemetics with different sites of activity would be more effective than one drug alone preventing PONV. Combination antiemetic regimens (e.g., ondansetron plus droperidol) are highly effective in the prevention of PONV. As non-pharmacological therapy, acupressure and acupuncture at the P6 (Nei-Kuwan) point are effective for preventing PONV. For the treatment of established PONV, granisetron is more effective than droperidol or metoclopramide.In the management of PONV after major gynecological surgery, the benefits and risks of these clinical strategies should be considered.

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“…Results from placebo-controlled studies of women in labor [23], women undergoing total hysterectomy [24], and patients undergoing emetogenic chemotherapy [25] support the antiemetic effect of injectable promethazine. However, other antiemetic medications have been found to be safe and effective in the prophylaxis of post-operative nausea and vomiting (PONV).…”

mentioning

confidence: 99%