Injectable promethazine: a risky drug of questionable efficacy

Cohen, M. R.; Stallone, Frank; Pallin, Daniel J.

doi:10.1007/s40267-016-0296-3

Cited by 4 publications

(1 citation statement)

References 13 publications

(10 reference statements)

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“…It possesses antihistamine, sedative, anti-motion sickness, and antiemetic effects. 2 Promethazine was the third most frequently prescribed antiemetic drug in the ED, after ondansetron and diphenhydramine. 3 Promethazine is highly caustic to the intima of blood vessels with a pH between 4 and 5.5, and inadvertent intra-arterial or subcutaneous (SQ) administration results in burning, erythema, pain, swelling, severe spasm of vessels, thrombophlebitis, venous thrombosis, nerve damage, paralysis, abscess, tissue necrosis, and gangrene.…”

Section: Discussionmentioning

confidence: 99%

An unusual adverse event with the use of intravenous bolus of promethazine (phenergan)

et al. 2017

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The earlier used sedatives like promethazine, pethidine and pentazocine (fortwin) are not commonly used these days but at times they are used especially in periphery for postoperative sedation and in gynecological surgeries and wards. We hereby report an unusual adverse event associated with the use of intravenous bolus of Promethazine. With this case report we want to highlight that if promethazine is to be used for any purpose it should be given preferably intramuscular and if given intravenously, should be diluted and given slowly in a good running cannula.

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Section: Discussionmentioning

confidence: 99%