The effect of probiotic supplementation on glycemic control and lipid profile in patients with type 2 diabetes: A randomized placebo controlled trial

Abstract

The role of gut microbiota in the pathogenesis of diabetes is increasing; this study investigates the effect of multi-strain probiotics on fasting plasma glucose (FPG), plasma insulin and lipid profile among patients. Methods: This randomized double blind controlled trial was performed among 60 patients; individuals were randomly assigned into 2 groups of 30 participants in order to take either probiotic supplements or placebo for 6 weeks. The probiotic supplement consisted of 7 viable strains Lactobacillus, Bifidobacterium and Streptococcus. Nutrient intakes were estimated using a 3-day and 24 hour-dietary recall at the beginning and end of study. Fasting blood samples were taken before and after intervention to measure the levels of FPG, plasma insulin and lipid profiles. Results: Within group comparisons showed significant decrease and increase in the levels of FPG (P ¼ 0.001) and HDL-C (P ¼ 0.002) in probiotic group, respectively. No significant alterations were observed for within and between group comparisons in the levels of insulin, triglycerides, total cholesterol, insulin resistance and anthropometric measurements, including weight, waist circumference and body mass index (all P > 0.05). Conclusions: This study showed a significant decrease in FPG level by multi-strain probiotic supplements in within group comparison; though, further studies are needed to confirm results.

Effects of probiotics on type II diabetes mellitus: a meta-analysis

“…The majority of the publications were excluded because they were irrelevant studies, case reports, or reviews. According to the inclusion and exclusion criteria, 15 publications (14 in English and 1 in Chinese) with a total of 902 patients were finally included [12,13,[15][16][17][18][19][20][21][22][23][24][25][26][27]. A flow chart showing the workflow for identifying and screening studies is presented in Fig.…”

“…However the effects of probiotics on human T2DM are inconsistent. Some studies showed that probiotics treatment reduced HbA1c, FBG or IR significantly in T2DM patients [12,13], while other studies did not find significant difference between patients with probiotics and placebo [14,15]. To evaluate the role of probiotics in T2DM patients comprehensively, and thus provide a theoretical basis for the extensive clinical application of probiotics in the treatment of T2DM, we performed a meta-analysis to evaluate the effects of probiotics on three indicators of T2DM, including HbA1c, FBG and homeostasis model assessment of IR (HOMA-IR).…”

A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics

“…Mahboobi et al [59] noticed that the consumption of a multi-species probiotic capsule did not alter the TC, LDL-C, HDL-C, or TG values in pre-diabetic subjects when compared to baseline and to that of the placebo control. Similarly, the supplementation of probiotic (Lactobacillus spp., Bifidobacterium spp., S. thermophilus) or synbiotic formulation (probiotics and fructo-oligosaccharide) did not amend the lipid profile of T2D patients [60,61].…”

“…Studies based on the intervention of multi-genus, multi-species, multi-strain (strains of same species) probiotic preparation has been reported with positive effect on lipid profile [24][25][26]28,[31][32][33][34][36][37][38][39]47,48], while several studies reported no effect of multi-genus and multi-species probiotic intervention on the lipid profile [55][56][57][58][59][60][61][62][63]. Even though intervention of Ecologic ® Barrier (B. bifidum W23, B. lactis W51, B. lactis W52, L. acidophilus W37, L. brevis W63, L. casei W56, L. salivarius W24, Lactococcus lactis W19 and W58) exhibit hypocholesterolemic effect on different subjects (individuals with T2D [38]; obese postmenopausal women [39]) with different intervention duration (six months [38]; 12 weeks [39]), dosage of probiotic mixture does not influence the cholesterol-lowering ability of the probiotic mixture.…”

Have Probiotics and Synbiotics passed the test of time to be implemented in management of obesity and related metabolic disorders-a comprehensive review

“…They found within group comparisons significant decrease in the levels of fasting blood glucose (FBG) (P=0.001) and increase in HDL-C (P=0.002).No significant changes were seen within and between group comparisons in the levels of insulin, triglycerides, TC, IR, weight, WC and BMI (allp>0.05).Thus concluding that a significant decrease in FPG level by multistrain probiotic supplements occurred within group comparisons though they advocated further studies to confirm results. 59…”