A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics

Sivamaruthi, Bhagavathi Sundaram; Kesika, Periyanaina; Chaiyasut, Chaiyavat

doi:10.3390/scipharm87040026

Cited by 26 publications

(21 citation statements)

References 57 publications

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“…Even though several advanced medical procedures (chemotherapy, surgery, immune and radiation therapy) are available for CRC treatment, the survival rates are poor with many adverse treatment-associated side effects, which affects the quality of the life [8]. Probiotics are a well-known bioactive candidate for the treatment of several diseases, and ill-health conditions [12][13][14][15][16][17][18]. e administration of probiotics in an adequate amount confers the health benefits to the host by positive regulation of the gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

The Role of Probiotics in Colorectal Cancer Management

Sivamaruthi

Kesika

Chaiyasut

2020

Evidence-Based Complementary and Alternative Medicine

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Colorectal cancer (CRC) is one of the most common cancerous diseases worldwide and causes leading cancer-associated deaths. Several factors are related to the incidence of CRC such as unhealthy diet and lifestyle, heredity, metabolic disorders, and genetic factors. Even though several advanced medical procedures are available for CRC treatment, the survival rates are poor with many adverse treatments associated side effects, which affects the quality of life. Probiotics are a well-known bioactive candidate for the treatment of several diseases and ill-health conditions. e recent scientific evidence suggested that probiotic supplementation protects the CRC patients from treatment-associated adverse effects. e manuscript summarizes the influence of probiotic supplementation on the health status of CRC patients and discusses the possible mechanism behind the protective effect of probiotics against CRC. e literature survey revealed that beneficial impact of probiotic supplementation depends on several factors such as strain, dosage, duration of the intervention, host physiology, and other food supplements. e probiotic intervention improves the microbiota, releases antimicrobials and anticarcinogenic agents, helps to remove carcinogens, and improves the intestinal permeability, tight junction function, and enzyme activity in CRC patients. Besides, not all probiotic strains exhibit anti-CRC activities; it is necessary to screen the potent strain for the development of a probiotic-based therapeutic agent to control or prevent the incidence of CRC.

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Section: Introductionmentioning

confidence: 99%

The Role of Probiotics in Colorectal Cancer Management

Sivamaruthi

Kesika

Chaiyasut

2020

Evidence-Based Complementary and Alternative Medicine

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“…Lactic acid bacteria, Bifidobacteria, Pediococcus , Leuconostoc , Streptococcus , Saccharomyces , Bacillus, and Enterococcus are the commonly used probiotic strains [7]. In recent decades, probiotics are recommended as a health supplement to improve health status and manage diseases and disorders [8,9,10,11,12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Probiotics Supplementations on Health Status of Athletes

Sivamaruthi

Kesika

Chaiyasut

2019

IJERPH

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Athletes are prone to several health complications, including upper respiratory tract infections, allergies, and gastrointestinal discomforts during practice and after the performance due to the intense exercise, travel, insufficient rest and restricted food consumption. Probiotics are well known as complementary therapeutic and health supplements for several diseases and disorders. Studies suggest that the intervention of probiotics improved the health status of elite athletes, but the results are not consistent in all the studies. The beneficial effect of probiotic supplementation profoundly relies on species or strain, dose, duration, form, and host physiology. The manuscript summarizes the effect of probiotic supplementation on health status of athletes. The literature was collected from PubMed, Scopus, Web of Science, and Google Scholar using the search term “probiotic and athletes”. As per the literature survey, probiotic supplementation improved the intestinal permeability, immune system, intestinal microbiota, inflammatory system, reduced the severity and incidence of respiratory tract infections, and duration of gastrointestinal symptoms. Several studies were conducted on Lactobacillus species and the outcomes were found to be species- or strain-specific. More studies are required to know the detailed mechanism behind the beneficial effect of probiotic intervention in athletes. Further studies are desired on formulation and optimization of probiotic supplements to develop generalized and personalized sports supplements to boost the overall health and enactment of elite athletes.

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“…Probiotic supplementation has been proved to reduce total cholesterol, LDL, and triglycerides and increase HDL count. The antihypertension capability of the probiotics makes them an affordable and adjunctive treatment option in hypertension, diabetes, and cardiovascular diseases, and other dyslipidemia-associated health issues [ 78 ]. SCFAs released by gut bacteria and probiotics are reported to regulate blood pressure (BP).…”

Section: Discussionmentioning

confidence: 99%

Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection

Patra

Saxena

Sahu

et al. 2021

Probiotics & Antimicro. Prot.

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With the alarming rise of infected cases and deaths, COVID-19 is a pandemic, affecting 220 countries worldwide. Until now, no specific treatment is available against SARS-CoV-2. The causal virus SARS-CoV-2 primarily infects lung cells, leading to respiratory illness ranging in severity from the common cold to deadly pneumonia. This, with comorbidities, worsens the clinical outcome, particularly for immunosuppressed individuals with COVID-19. Interestingly, the commensal gut microbiota has been shown to improve lung infections by modulating the immune system. Therefore, fine-tuning of the gut microbiome with probiotics could be an alternative strategy for boosting immunity and treating COVID-19. Here, we present a systematic biological network and meta-analysis to provide a rationale for the implementation of probiotics in preventing and/or treating COVID-19. We have identified 90 training genes from the literature analysis (according to PRISMA guidelines) and generated an association network concerning the candidate genes linked with COVID-19 and probiotic treatment. The functional modules and pathway enrichment analysis of the association network clearly show that the application of probiotics could have therapeutic effects on ACE2-mediated virus entry, activation of the systemic immune response, nlrp3 -mediated immunomodulatory pathways, immune cell migration resulting in lung tissue damage and cardiovascular difficulties, and altered glucose/lipid metabolic pathways in the disease prognosis. We also demonstrate the potential mechanistic domains as molecular targets for probiotic applications to combat the viral infection. Our study, therefore, offers probiotics-mediated novel preventive and therapeutic strategies for COVID-19 warfare.

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A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics

Cited by 26 publications

References 57 publications

The Role of Probiotics in Colorectal Cancer Management

The Role of Probiotics in Colorectal Cancer Management

Effect of Probiotics Supplementations on Health Status of Athletes

Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection

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