The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life

Borewicz, Klaudyna; Suárez-Diez, María; Hechler, Christine; Beijers, Roseriet; Weerth, Carolina de; Arts, Ilja C. W.; Penders, John; Thijs, Carel; Nauta, Arjen; Lindner, Cordula; Leusen, Ellen van; Vaughan, Elaine E.; Smidt, Hauke

doi:10.1038/s41598-018-38268-x

Cited by 74 publications

(71 citation statements)

References 61 publications

(66 reference statements)

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“…Thus, we aimed to determine whether S. mutans grows on HMOs and other prebiotics, such as GOS, which are also added to infant formulas. 2 0 -FL has been studied in infant formula at 0•2-1 g/l, for other health indications than oral health, as have GOS levels at 0•2-0•5 g/dl (5,6,9,10,33) . The 2 0 -FL concentrations that we tested exceeded those in infant formula and were slightly higher than GOS concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Influence of 2′-fucosyllactose and galacto-oligosaccharides on the growth and adhesion of Streptococcus mutans

et al. 2020

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Abstract Human milk oligosaccharides, such as 2′-fucosyllactose (2′-FL), and galacto-oligosaccharides (GOS), a prebiotic carbohydrate mixture, are being increasingly added to infant formulas, necessitating the understanding of their impact on the oral microbiota. Here, for the first time, the effects of 2′-FL and GOS on the planktonic growth and adhesion characteristics of the caries-associated oral pathogen Streptococcus mutans were assessed, and the results were compared against the effects of xylitol, lactose and glucose. There were differences in S. mutans growth between 2′-FL and GOS. None of the three S. mutans strains grew with 2′-FL, while they all grew with GOS as well as lactose and glucose. Xylitol inhibited S. mutans growth. The adhesion of S. mutans CI 2366 to saliva-coated hydroxyapatite was reduced by 2′-FL and GOS. Exopolysaccharide-mediated adhesion of S. mutans DSM 20523 to a glass surface was decreased with 2′-FL, GOS and lactose, and the adhesion of strain CI 2366 strain was reduced only by GOS. Unlike GOS, 2′-FL did not support the growth of any S. mutans strain. Neither 2′-FL nor GOS enhanced the adhesive properties of the S. mutans strains, but they inhibited some of the tested strains. Thus, the cariogenic tendency may vary between infant formulas containing different types of oligosaccharides.

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Section: Discussionmentioning

confidence: 99%

“…Galacto-oligosaccharides (GOS) are a mixture of lactose-based oligosaccharides with varying lengths and linkages between glucose and galactose, the terminal unit being glucose (8) . GOS are often used in infant formulas to mimic the prebiotic features of human milk (8)(9)(10) .…”

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confidence: 99%

Influence of 2′-fucosyllactose and galacto-oligosaccharides on the growth and adhesion of Streptococcus mutans

et al. 2020

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“…They are widely distributed in a variety of plants as a storage carbohydrate [ 8 ]. Several products have been enriched with these prebiotic compounds to increase their functionality like semi-hard cheese [ 9 ], fermented sausages [ 10 ], Greek yogurt [ 11 ], fruit juices [ 12 ], infant formulas [ 13 ], and many others. Recently Brazilian ginseng ( Pfaffia glomerata ) roots were recognized as a new source of short-chain FOS, including 1-kestose, nystose, and fructofuranosylnystose with up to 8.8 g/100 g of prebiotic carbohydrates [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Supercritical CO2 Processing of a Functional Beverage Containing Apple Juice and Aqueous Extract of Pfaffia glomerata Roots: Fructooligosaccharides Chemical Stability after Non-Thermal and Thermal Treatments

et al. 2020

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The effects of supercritical CO2 processing on the chemical stability of fructooligosaccharides (FOS) and other functional and nutritional compounds were evaluated employing non-thermal and thermal approaches. Apple juice was enriched with Pfaffia glomerata roots aqueous extract due to its high content of short-chain FOS and then subjected to different levels of temperature (40 and 60 °C), pressure (8 and 21 MPa), and CO2 volume ratio (20 and 50%). The percentage of CO2 volume was evaluated concerning the total volume of the high-pressure reactor. Also, the functional beverage was thermally treated at 105 °C for 10 min. Physicochemical properties (pH and soluble solid content), beta-ecdysone, sugars (glucose, fructose, and sucrose), and FOS (1-kestose, nystose, and fructofuranosylnystose) content were determined. The pH and soluble solid content did not modify after all treatments. The pressure and CO2 volume ratio did not influence the FOS content and their chemical profile, however, the temperature increase from 40 to 60 °C increased the nystose and fructofuranosylnystose content. High-temperature thermal processing favored the hydrolysis of 1-kestose and reduced the sucrose content. Regarding beta-ecdysone, its content remained constant after all stabilization treatments demonstrating thus its high chemical stability. Our results demonstrated that supercritical CO2 technology is a promising technique for the stabilization of FOS-rich beverages since the molecular structures of these fructans were preserved, thus maintaining their prebiotic functionality.

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“…Other studies have shown similarities between the bifidogenic effect of prebiotic-fortified formulae and HBM, as compared to non-fortified formulae [59,68,69]. Indeed, prebiotics have been reported to have special effects on some bifidobacteria species such as Bifidobacterium breve.…”

Section: Prevention and Treatment Of Infant Disordersmentioning

confidence: 92%

Probiotics and Prebiotics in Infant Formulae

Maldonado¹

2020

Prebiotics and Probiotics - Potential Benefits in Nutrition and Health

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Human breast milk provides all necessary nutrients for the development of term infants. In addition to its universally recognized nutrients, human breast milk contains a number of non-nutritive components that play a potential role in supporting infant growth. Human breast milk also contains bioactive compounds exerting a wide range of beneficial effects, such as promoting immune system maturation and exerting protection against infections. Supplementation of infant formulae with oligosaccharides and bacteria with proven beneficial health effects seems to be well-founded. The purpose of supplementation is to mimic the functional effects of oligosaccharides and bacteria found in human breast milk. Oligosaccharides with prebiotic functions and bacteria strains with probiotic functions have recently been added to infant formulae in the European Union and other countries. However, a systematic review conducted by the Committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition revealed that there is no conclusive evidence supporting the routine use of probiotic-and/or prebiotic-fortified infant formulae. The aim of this review is to analyze the scientific basis for supplementation of infant formula with these compounds.

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The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life

Cited by 74 publications

References 61 publications

Influence of 2′-fucosyllactose and galacto-oligosaccharides on the growth and adhesion of Streptococcus mutans

Influence of 2′-fucosyllactose and galacto-oligosaccharides on the growth and adhesion of Streptococcus mutans

Supercritical CO2 Processing of a Functional Beverage Containing Apple Juice and Aqueous Extract of Pfaffia glomerata Roots: Fructooligosaccharides Chemical Stability after Non-Thermal and Thermal Treatments

Probiotics and Prebiotics in Infant Formulae

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