The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization

Özakar, Rukiye Sevinç; Özakar, Emrah

doi:10.29228/jrp.57

Cited by 2 publications

(4 citation statements)

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“…Due to the high solubility of pseudoephedrine HCl in water, a decrease in encapsulation efficiency was observed due to diffusion from pellets back into the aqueous medium. A similar result was seen in sodium alginate beads that we made with ampicillin sodium, which is soluble in water [45]. In addition, the crosslinking time has an effect on the encapsulation efficiency.…”

Section: Encapsulation Efficacy Drug Loading Capacity and Yieldsupporting

confidence: 81%

“…In SGF and SIF release results of pellets containing erdosteine, ibuprofen and pseudoephedrine HCl were applied to the computer program to determine the kinetic model of the release from lyophilized pellets. Whether pellets are compatible with Zero-Order, First-Order, Higuchi, or Korsmeyer-Peppas kinetic models were determined by mathematical formulas [45].…”

Section: Release Kineticsmentioning

confidence: 99%

“…It is seen that the pellets containing ibuprofen comply with the Super Case-II Transport release mechanism, since the "n" value is greater than 0.89 at pH 6.8 SIF. This means that drug molecules diffuse throughout the highly hydrated polysaccharide matrix, which is involved in the dissolution or relaxation of polymer chains [45].…”

Section: Release Kineticsmentioning

confidence: 99%

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A New Triple Combination for Upper Respiratory Tract Infections: Preparation and Evaluation of Sustained- Release Pellet Formulations Containing Erdosteine, Ibuprofen and Pseudoephedrine HCL

ÖZAKAR¹

2022

FARMACIA

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Pharmaceutical preparations containing erdosteine, ibuprofen, and pseudoephedrine HCl are among the most prescribed drugs in the treatment of upper respiratory infections. Physicians are obliged to write separately or in combinations of dual since there is no single combined dosage form containing these three active substances at the same time. In this study, for the first time, erdosteine, ibuprofen, and pseudoephedrine HCl were combined, and a different dosage form was prepared apart from the dosage forms available in the pharmaceutical market. First of all, an analytical method that can analyse erdosteine, ibuprofen, and pseudoephedrine HCl at the same time was developed by high-performance liquid chromatography (HPLC) and validation of this method was performed. Afterward, pellet formulations were developed with these three active substances and characterized by using various techniques (encapsulation efficiency, drug loading capacity, yields, particle size and distributions, swelling degrees, in vitro release properties, release kinetics, morphologies, DSC thermograms, FT-IR spectra, XRD diffractograms, and stabilities). XRD study of erdosteine was performed for the first time in the literature. Pellets have been successfully developed without any change or incompatibility in the structure of the active substances. RezumatPreparatele farmaceutice care conțin erdosteină, ibuprofen și clorhidrat de pseudoefedrină sunt printre cele mai prescrise medicamente în tratamentul infecțiilor căilor respiratorii superioare. Medicii sunt obligați să prescrie separat sau în combinații duale, deoarece nu există un singur preparat combinat care să conțină aceste trei substanțe active. În acest studiu, pentru prima dată, erdosteina, ibuprofenul și pseudoefedrina HCl au fost combinate și a fost preparată o formă farmaceutică diferită de cele disponibile pe piața farmaceutică. A fost dezvoltată și validată o metodă HPLC care poate analiza erdosteina, ibuprofenul și pseudoefedrina HCl simultan. Ulterior, au fost dezvoltate formulări de pelete cu aceste trei substanțe active și caracterizate prin diferite tehnici: eficiența încapsulării, capacitatea de încărcare a medicamentului, dimensiunea și distribuția particulelor, gradul de gonflare, proprietățile de cedare in vitro, cinetica de eliberare, termogramele DSC, FT-IR, difractogramele XRD și studii de stabilitate.

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Section: Encapsulation Efficacy Drug Loading Capacity and Yieldsupporting

confidence: 81%

Section: Release Kineticsmentioning

confidence: 99%

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A New Triple Combination for Upper Respiratory Tract Infections: Preparation and Evaluation of Sustained- Release Pellet Formulations Containing Erdosteine, Ibuprofen and Pseudoephedrine HCL

ÖZAKAR¹

2022

FARMACIA

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“…EE%, LC%, and Y% of the formulations were calculated as Ⴟ±SD using the formulas below. Each formulation was studied in triplicate [25].…”

Section: Size Ee% Lc% and Y% Of Hollowbeads Formulations Containing I...mentioning

confidence: 99%

İndometazi̇n İçeren Yüzen-Pulsati̇l İçi̇ Boş Boncuklarin Hazirlanmasi Ve i̇n-Vi̇tro Karakteri̇zasyonu

Özakar

GÜNEŞ²,

Özakar

2022

Ankara Ecz. Fak. Derg.

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Objective: Objective: Designing matrix structured controlled release systems using polymers or waxy lipids is a popular option today. Hollowbeads are formulations characterized by the formation of an air-filled cavity inside. In our study, indomethacin was chosen as a model drug. Cetyl alcohol was selected to create the hollowbeads structure, and NaCMC was chosen to achieve long-term release. Kollicoat® MAE100P was used to reduce and/or prevent ulcer formation and control release.Material and Method: The formulations were prepared using a new “wax removal” technique. Different concentrations of ZnCl2 and CaCl2 were used as crosslinkers. In the preformulation studies, 24 different formulations were prepared by changing the amount of NaCMC, the amount of crosslinker, and the crosslinking time. The structure, size, encapsulation efficiency, yield, hollow structure, and long-term release capacity were investigated in the formulations. These parameters were statistically evaluated depending on the amount of NaCMC, the type of crosslinker, the amount of crosslinker, and contact times with the crosslinker.Result and Discussion: Hollowbeads were characterized by SEM and FT-IR. In vitro release studies, release kinetics, and release mechanisms were performed in pH 1.2 HCl and pH 6.8 phosphate buffer media. Swelling, and buoyancy studies were performed. The long-term stability, encapsulation efficiencies, drug loading efficiencies, and yields of the formulations were also evaluated. Two promising formulations (F2 and F19) were found to be able to release indomethacin in both the stomach and intestinal media for 24 hours.

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The effect of polymer amount and crosslinker ratio in polymeric hydrogel beads on characterization

Cited by 2 publications

References 0 publications

A New Triple Combination for Upper Respiratory Tract Infections: Preparation and Evaluation of Sustained- Release Pellet Formulations Containing Erdosteine, Ibuprofen and Pseudoephedrine HCL

A New Triple Combination for Upper Respiratory Tract Infections: Preparation and Evaluation of Sustained- Release Pellet Formulations Containing Erdosteine, Ibuprofen and Pseudoephedrine HCL

İndometazi̇n İçeren Yüzen-Pulsati̇l İçi̇ Boş Boncuklarin Hazirlanmasi Ve i̇n-Vi̇tro Karakteri̇zasyonu

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