The effect of polycythemia vera on hearing functions: Evaluation of twenty‐one patients

Dogan, Esma Evrim; Uslu, Mustafa; Özkan, Melda Cömert; Ünal, Hatice Demet Kiper; Saydam, Güray; Töbü, Mahmut

doi:10.1111/coa.13303

Cited by 5 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study by Dogan et al, patients with known PV were compared to healthy controls. Cochlear impairment was found to be significantly more common in PV group (p = 0.004) [10].…”

Section: Discussionmentioning

confidence: 91%

Polycythemia Vera Presenting as Tinnitus and Hearing Loss: A Case Report

Thong

Goh

Saim³

2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Polycythemia vera (PV) is a chronic myeloproliferative neoplasm (MPN) characterized by erythrocytosis and commonly associated with the JAK2 V617F mutation. PV is a relatively rare disease with a prevalence rate of 22 per 100,000. Historically, hearing impairments were first described as a complication of PV in 1963, and it was stated that symptoms recovered after a phlebotomy. Occlusion and thrombosis of the feeding labyrinthine artery causing cochlear ischemia were thought to be the cause of such symptoms and complaints. CASE PRESENTATION: We are reporting a case of PV that was presented in our ENT outpatient clinic. The patient presented with a main complaint of sudden-onset bilateral tinnitus with one-sided hearing loss. The patient was treated medically with hydroxyurea, aspirin, and phlebotomy. On improvement of the hematological parameters, the patient noted an improvement in his hearing and it was confirmed with the finding on the repeated hearing assessment. CONCLUSION: This case emphasizes the importance of otolaryngologists remaining vigilant and maintaining a high index of suspicion as PV can present with audiological symptoms. The early diagnosis and initiation of treatment can improve patients’ hearing and reduce the morbidity of such patients.

show abstract

“…In a study by Dogan et al, patients with known PV were compared to healthy controls. Cochlear impairment was found to be significantly more common in PV group (p = 0.004) [10].…”

Section: Discussionmentioning

confidence: 91%

Polycythemia Vera Presenting as Tinnitus and Hearing Loss: A Case Report

Thong

Goh

Saim³

2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…Increased blood viscosity is capable of causing hearing loss by impairing cochlear microvascular circulation 16 . Doğan et al investigated the effect on hearing of polycythemia vera and determined a positive correlation between HB levels, platelet count and cochlear involvement 17 . In another study, HgB levels were positively correlated with audiometric results in patients with gout, but negatively correlated with TEOAE signal to noise (S/N) ratio results 3 .…”

Section: Discussionmentioning

confidence: 99%

“…16 Do gan et al investigated the effect on hearing of polycythemia vera and determined a positive correlation between HB levels, platelet count and cochlear involvement. 17 In another study, HgB levels were positively correlated with audiometric results in patients with gout, but negatively correlated with TEOAE signal to noise (S/N) ratio results. 3 While a significant difference was observed in terms of HgB values between patients with gout and the control group in the present study, no difference was observed in terms of RBC or Hct values.…”

Section: F I G U R E 1 (A) Hearing Thresholds Of Right Ear (B) Hearin...mentioning

confidence: 94%

Early hearing loss detection in gout using extended high frequency audiometry

Şahin

Kılıç

Sakat

et al. 2022

Clinical Otolaryngology

View full text Add to dashboard Cite

Objective The study aimed to analyse the hearing levels of patients with gout using extended high frequencies (EHFs) audiometry. Thus, we aimed to reveal the early detectability of potential hearing losses. Design Comparative cross‐sectional study. Settings A single centre patient was diagnosed with gout disease. Participants Two groups consisted of 32 patients with gout and 32 healthy volunteers. Main Outcome Measures The primary outcome was hearing thresholds in pure tone (PT) audiometry and EHFs audiometry. Also, the association between audiometric results and haematological and biochemical parameters were evaluated. Results There was no significant difference between groups in terms of mean hearing thresholds in PT audiometry. But, at all frequencies above 4000 Hz (4000–18 000 Hz), the hearing thresholds were significantly higher in patients with gout. Also, the hearing thresholds above 8000 Hz were positively correlated with serum uric acid levels. Hearing thresholds at higher frequencies were positively correlated with haemoglobin levels and negatively correlated with high‐density lipoprotein levels. Conclusion To our knowledge, this is the first study in the literature demonstrating the high frequency of hearing loss in patients with gout using EHFs audiometry. We consider that using EHFs audiometry should have an important place in the early detection of potential hearing losses in gout patients.

show abstract

“…Serum hyperviscosity could manifest with bilateral sensorineural hearing loss. In the setting of massive splenomegaly, hyperviscosity may be related to the following: 1) high white cell counts, seen in chronic myeloid leukemia, 3 2) hematocrit, seen in polycythemia vera, 4 or 3) hypergammaglobulinemia, either monoclonal associated with Waldenstrom's macroglobulinemia, 5 or polyclonal associated with tropical infections (malaria and visceral leishmaniasis). 6,7 If left untreated, visceral leishmaniasis could cause bone marrow suppression (pancytopenia), immune dysfunction (recurrent bacterial infections), cachexia, hypoalbuminemia, edema, liver dysfunction (jaundice, ascites), renal impairment (proteinuria, hematuria, azotemia secondary to glomerulonephritis or interstitial nephritis), or bleeding diathesis (thrombocytopenia and liver dysfunction).…”

Section: Clinical Communication To the Editormentioning

confidence: 99%