The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty

Abstract

Purpose This study investigated the efficacy of platelet-rich plasma (PRP) on articular surfaces on which the mosaicplasty technique was performed. Our hypothesis was that PRP can accelerate the osseointegration process and enhance the quality of articular integrity after the mosaicplasty procedure. Methods Standard defects were created in the femoral groove of both patellofemoral joints of 12 New Zealand rabbits. PRP solution was placed inside the defect before fixation of the osteochondral autografts and injected inside the involved joint after capsular closure of the tested knees. The contralateral knees served as the control sides. The animals were euthanized three or six weeks after mosaicplasty, and both limbs were assessed according to Pineda's histological grading scale. Significance level was set at p≤0.05 a priori, and the Mann-Whitney U test was used for statistical analysis. Results Histologic findings at the interface between the transferred autograft and the original cartilage revealed better integration of the adjacent surfaces in the mosaicplasty with PRP group three weeks after the procedure; the difference was significant (p<0.05). However, no significant difference in the transition zone was observed between the groups six weeks after the experiment (p=0.59). Conclusions Our animal model showed that adjunctive use of PRP produced a better healing response and resulted in superior histological scores after three weeks compared with the mosaicplasty-only procedure. Interpretation of our results is important in terms of rapid return to previous activity levels. Thus, application of PRP can represent a valid therapeutic option for improving the efficacy of mosaicplasty by stimulating the local healing response.

The role of platelet rich plasma in management of fracture neck femur: new insights

“…Also, age is another important factor that may have a direct influence on the haematological character of PRP. In an animal study done by Urgas et al [16] about the efficacy of PRP on integration of osteochondral defects with mosaicoplasty, he found that PRP produced a better healing response with superior histological scores than the control group [16]. The incidence of AVN in our study was (6.7 %) in group A and (3.3 %) in group B with and overall incidence of 5 %.…”

Therapeutic potential of platelet-rich plasma in diseases and injuries of the large joints

“…В другой экспериментальной работе на 12 кроликах полнослойный дефект хряща коленного сустава замещали методом мозаичной аутохондропластики. Авторы сообщают о лучших результатах мозаичной аутохондропластики, ассоциированной с применением PRP [25].…”

Development of biodegradable membranes for the delivery of a bioactive chitosan‐derivative on cartilage defects: A preliminary investigation

“…The repair of cartilage defects poses some challenges due to the limited ability of tissue self‐healing and to the fact that current treatments often lead to the synthesis and deposition of fibrocartilage, which lacks the mechanical and functional properties of hyaline cartilage (Armiento, Alini, & Stoddart, ; Karuppal, ). The treatment of cartilage damages can be managed by administration of compounds such as corticosteroids (Jüni et al, ; Wernecke, Braun, & Dragoo, ), hyaluronic acid (Jang et al, ; Strauss, Schachter, Frenkel, & Rosen, ), and platelet‐rich plasma (Altan, Aydin, Erkocak, Senaran, & Ugras, ; Montañez‐Heredia et al, ).…”