The Effect of Plasma Reactions on Arsenic Measurement by ICP Spectrometry

Chiba, Koichi; Narukawa, Tomohiro

doi:10.2116/analsci.30.175

Cited by 5 publications

(6 citation statements)

References 50 publications

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“…For example, chlorinated solvents may result in ICP-MS polyatomic interferences especially for 75 As [90] e.g. Typically helium, ammonia, hydrogen and oxygen gas are used to eliminate interferences [30,90,215] and more recently SF 6 [216]. Substitution of problem buffers, for example buffers containing chloride with carbonate, is often possible.…”

Section: Use Of Hydride Generationmentioning

confidence: 99%

“…If a mobile phase containing high concentrations of sodium hydroxide is required for chromatography, the sodium will need to be removed as sodium entering the ICPMS suppresses the As signal [56,215] and causes severe baseline drift. A self-regenerating suppressor can be used to remove sodium and OH converted electrochemically to water prior to sample introduction into the ICPMS [220].…”

Section: Icpms Interferences and Signalsmentioning

confidence: 99%

“…Mass interferences by polyatomic species with the same mass to charge ratio as As can be removed by the use of a dynamic reaction or collision cell during the measurement phase. 88 Typically helium, ammonia, hydrogen and oxygen gas are used to eliminate interferences 30,88,211 and more recently SF 6 . 212 Helium, for example, can be used to suppress 40 Ar 35 Cl + formation but also suppresses 75 As + intensity ($50%) at high helium ow rates.…”

Section: Hplc-icpms or Hplc-hg-afsmentioning

confidence: 99%

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Measurement of arsenic species in environmental, biological fluids and food samples by HPLC-ICPMS and HPLC-HG-AFS

Maher

Ellwood

Krikowa

et al. 2015

J. Anal. At. Spectrom.

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The importance of measuring arsenic (As) species has been appreciated for a long time mainly because of the wide spread knowledge of arsenic's toxicity and its use as a poison. Increasingly health, environmental and food regulations have been written around As species rather than total concentrations. Knowledge of As speciation is important as the chemical form of As controls its bioavailability, toxicity, mobility and therapeutic benefits. Arsenic is present as inorganic (arsenate, arsenite, thioarsenates), complexed (arsenic glutathionines and phytochelatins), low molecular weight (monomethylarsonate, dimethylarsenite, arsenobetaine, arsenocholine etc.) and high molecular weight ( arsenic hydrocarbons and arsenic phospholipids) species. In this review we cover the intergrity of As species during collection, storage, sample preparation and measurement by HPLC-ICPMS and HPLC-HG-AFS. The major conclusion is that it is essential to ensure that As species, especially in waters and sediments, are not artefacts of the preservation or extraction procedure. Most biota and sediment samples can be stored frozen (-20 o C), but the stability of water and sediment samples is matrix dependent and depends on preservation technique applied. Arsenic cannot be extracted from samples using a single set of conditions but must be optimised for each sample type. Methanol-water mixtures with microwave heating are commonly used to extract polar As species from tissues while As-lipids required a non-polar solvent. Dilute acid can be used to increase the efficiencies of extraction of hard to extract tissue As species. Freeze drying is suitable for the drying of biotic material while sediments should not be dried before analysis. Extraction efficiencies are critically dependent on particle size. Polar As species have a wide variety of ionic characteristics thus complimentary chromatographic 4 Understanding the action of a chemical species in a food stuff or nutritional supplement: As mentioned above, some food regulations require specification of the active ingredient of foodstuffs or supplements. However, another important reason for determining the chemical species is to understand the beneficial action of an element. For example, many food stuffs are promoted for their anti-carcinogenic activity [8]. Evaluation of the role of As in preventing cancers has required the active species to be identified [8,9].Increasingly health, environmental and food regulations have been written around a knowledge of As species rather than total concentrations. In the environment, As is present as inorganic (arsenate (As(V)), arsenite (As(III)), thioarsenates), complexed, (As glutathionines (AsGSH) and phytochelatins (AsPC)), low molecular weight [monomethylarsonate (MA), dimethylarsenite (DMA), arsenobetaine (AB), arsenocholine (AC) etc.] and higher molecular weight (As hydrocarbons and As phospholipids) species (Table 1). Volatile As species (TMAs, As-hydrides) are also produced by bacteria and fungi [10,11].Arsenic is present in all organisms, but is ...

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Section: Use Of Hydride Generationmentioning

confidence: 99%

Section: Icpms Interferences and Signalsmentioning

confidence: 99%

Section: Hplc-icpms or Hplc-hg-afsmentioning

confidence: 99%

See 1 more Smart Citation

Measurement of arsenic species in environmental, biological fluids and food samples by HPLC-ICPMS and HPLC-HG-AFS

Maher

Ellwood

Krikowa

et al. 2015

J. Anal. At. Spectrom.

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“…It is well known that there are some polyatomic molecules interfering with As and Cd measurements in ICP-MS. [12][13][14] If a certain amount of Mo is contained in the samples, MoO will interfere with Cd, and especially the interference of 98 Mo 16 O with 114 Cd is very severe. 15,16 Therefore, the Cd concentrations were determined using two ICP-MSs installed with different types of the collision reaction cell gas system.…”

Section: Arsenic and Cadmium Concentrations Of Tobacco Leaves Ash Anmentioning

confidence: 99%

Arsenic Speciation and Cadmium Determination in Tobacco Leaves, Ash and Smoke

2016

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The concentrations of arsenic (As) and cadmium (Cd) in the tobacco leaves, ash and smoke of 10 kinds of cigarettes collected from different countries worldwide were determined by ICP-MS after microwave-assisted digestion. Total As and Cd concentrations in the tobacco leaves ranged from 0.20 to 0.63 and 1.8 to 9.9 mg kg -1 , respectively. By the speciation analysis of As in tobacco leaves and ash by HPLC-ICP-MS following acid extraction, arsenite [As(III)] and arsenate [As(V)] were determined and trace amounts of monomethylarsonic acid (MMAA), dimethylarsinic acid (DMAA), trimethylarsine oxide (TMAO), tetramethylarsonium (TeMA) and some unidentified As species were also found. Arsenic speciation for smoke absorbed in an aqueous solution was carried out. The sum of the As species in tobacco leaves, ash and smoke was in good agreement with the result of total As determination in each sample, and the recoveries of speciation were 100 ± 10%. The distributions and the behaviors of As species were clarified.

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“…The exogenous toxic metal arsenic also suffers from a polyatomic interference in high salt solutions due to the formation of the ArCl species in the plasma, necessitating its analysis in KED mode. [19] It is possible that the use of higher resolution analysis modes, such as by sector-field ICP-MS (SF-ICP-MS) could provide higher sensitivity and lower limits of detection for challenging elements. [20]…”

Section: Discussionmentioning

confidence: 99%

Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

Harrington

Young

Fry

et al. 2015

Biol Trace Elem Res

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Trace elements can play an important role in maternal health and fetal development, and deficiencies in some essential minerals including zinc and copper have been correlated in some individuals to the development of birth defects and adverse health outcomes later in life. The exact etiology of conditions like preeclampsia and the effects of fetal exposure to toxic metals has not been determined, making the assessment of trace element levels crucial to the elucidation of the causes of conditions like preeclampsia. Previous studies analyzing serum and placenta tissue have produced conflicting findings, suggesting the need for a robust, validated sample preparation and analysis method for the determination of trace elements in placenta. In this report, an acid digestion method and analysis by ICP-MS for a broad metallomics/mineralomics panel of trace elements is developed and validated over three experimental days for inter- and intraday precision and accuracy, linear range, matrix impact, and dilution verification. Spike recovery experiments were performed for the essential elements chromium (Cr), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), and zinc (Zn), and the toxic elements arsenic (As), cadmium (Cd), and lead (Pb) at levels equal to and in excess of native concentrations in control placenta tissue. The validated method will be essential for the development of scientific studies of maternal health and toxic metal exposure effects in childhood.

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The Effect of Plasma Reactions on Arsenic Measurement by ICP Spectrometry

Cited by 5 publications

References 50 publications

Measurement of arsenic species in environmental, biological fluids and food samples by HPLC-ICPMS and HPLC-HG-AFS

Measurement of arsenic species in environmental, biological fluids and food samples by HPLC-ICPMS and HPLC-HG-AFS

Arsenic Speciation and Cadmium Determination in Tobacco Leaves, Ash and Smoke

Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

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