Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

Harrington, James M.; Young, Daniel J.; Fry, Rebecca C.; Weber, Frank; Sumner, Susan; Levine, Keith

doi:10.1007/s12011-015-0431-3

Cited by 9 publications

(4 citation statements)

References 44 publications

(44 reference statements)

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“…All isotopes were analysed using the collision cell technique at 5 mL/min collision gas flow (93% He and 7% H 2 ). To determine the DRF, the sensitivity on each day was divided by the sensitivity of the matrix adjusted calibration of that day: LOD and LOQ were determined using the blank value method 43 . The data of the control group (5 animals) were used for the determination of the lowest detectable signal.…”

Section: Icp-ms Measurementsmentioning

confidence: 99%

Aluminum and aluminum oxide nanomaterials uptake after oral exposure - a comparative study

Krause

Kriegel

Rosenkranz

et al. 2020

Sci Rep

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The knowledge about a potential in vivo uptake and subsequent toxicological effects of aluminum (Al), especially in the nanoparticulate form, is still limited. This paper focuses on a three day oral gavage study with three different Al species in Sprague Dawley rats. The Al amount was investigated in major organs in order to determine the oral bioavailability and distribution. Al-containing nanoparticles (NMs composed of Al 0 and aluminum oxide (Al 2 o 3)) were administered at three different concentrations and soluble aluminum chloride (AlCl 3 •6H 2 O) was used as a reference control at one concentration. A microwave assisted acid digestion approach followed by inductively coupled plasma mass spectrometry (ICP-MS) analysis was developed to analyse the Al burden of individual organs. Special attention was paid on how the sample matrix affected the calibration procedure. After 3 days exposure, AlCl 3 •6H 2 o treated animals showed high Al levels in liver and intestine, while upon treatment with Al 0 NMs significant amounts of Al were detected only in the latter. In contrast, following Al 2 o 3 NMs treatment, Al was detected in all investigated organs with particular high concentrations in the spleen. A rapid absorption and systemic distribution of all three Al forms tested were found after 3-day oral exposure. The identified differences between Al 0 and Al 2 o 3 NMs point out that both, particle shape and surface composition could be key factors for Al biodistribution and accumulation. Aluminum is one of the most abundant elements on earth and is widely used in many different consumer product applications due to its unique characteristics. As an ubiquitous element, Al occurs in natural sources, e.g. food and drinking water, as well as in food additives, packaging and kitchenware 1,2. Besides industrial, also agricultural, medical and consumer product uses are known for synthetic alumina, mixed Al silicate and Al oxide NMs. Especially composite materials containing Al show favourable properties when being used as packaging materials for the protection of food against humidity and oxidation and are more and more common 3-6. Moreover, various Al salts are used in food as additives, e.g. as stabilizers, pH regulators and anti-caking agents 7,8. As a consequence of modern life style Al-containing materials and substances are of high abundance in the human environment. In our study we could show de novo synthesis of Al-containing nanomaterials from ions after induction of a pH shift 9. Based on this and because of the detection and quantification of Al in biological media is difficult, one should assume at least partial particle concentration in the body after oral uptake of Al. This raises questions about the potential hazard of particulate Al species. Adverse effects of Al have been repeatedly discussed in the past. Neurodegenerative diseases such as Alzheimer's 10,11 as well as certain bone diseases 12-14 and dialysis dementia 15,16 have been attributed to Al exposure. Although inhalation and dermal uptake of Al may ...

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Section: Icp-ms Measurementsmentioning

confidence: 99%

Aluminum and aluminum oxide nanomaterials uptake after oral exposure - a comparative study

Krause

Kriegel

Rosenkranz

et al. 2020

Sci Rep

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“…Metalloproteins provide a direct link between elemental metabolomics and proteomics and we expect that increasing number of metabolite measurements will be done by direct measurement of elements. Furthermore, increasing number of specialized multielement clinical testing have been validated [134,135] and ICP-MS is used routinely for large number of laboratory tests for total elements in biological samples (Ag, Al, As, Ba, Be, Bi, Cd, Cr, Co, Cu, Fe, Gd, Hg, I, Mg, Mn, Mo, Ni, Pb, Pt, Se, Sb, Sn, Th, Ti, U, V, Zn), including several metal panels, in reputable clinical laboratories [136].…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Elemental metabolomics

2017

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Elemental metabolomics is quantification and characterization of total concentration of chemical elements in biological samples and monitoring of their changes. Recent advances in inductively coupled plasma mass spectrometry have enabled simultaneous measurement of concentrations of > 70 elements in biological samples. In living organisms, elements interact and compete with each other for absorption and molecular interactions. They also interact with proteins and nucleotide sequences. These interactions modulate enzymatic activities and are critical for many molecular and cellular functions. Testing for concentration of > 40 elements in blood, other bodily fluids and tissues is now in routine use in advanced medical laboratories. In this article, we define the basic concepts of elemental metabolomics, summarize standards and workflows, and propose minimum information for reporting the results of an elemental metabolomics experiment. Major statistical and informatics tools for elemental metabolomics are reviewed, and examples of applications are discussed. Elemental metabolomics is emerging as an important new technology with applications in medical diagnostics, nutrition, agriculture, food science, environmental science and multiplicity of other areas.

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“…Mineral concentrations were assessed using the inductively coupled plasma methods that have recently been validated for its applicability to the analysis of young people exposure to minerals [10].…”

Section: Methodsmentioning

confidence: 99%

Hair and Saliva Trace Elements Content in Young Athletes from Kazan Region, Russia

Nv¹,

Aa²,

Av³

et al. 2017

J Osteopor Phys Act

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Active physical exercises are associated with high body mineral demand that can cause mineral disbalances with diverse negative health outcomes. The purpose of this study is to examine the impact of sport-related factors on mineral composition in young athletes. Saliva and hair samples were chosen for the analysis as reflecting immediate and more permanent mineral status, respectively.The samples were analysed by spectral methods with inductively coupled plasma for eight essential minerals: calcium (Ca), chromium (Cr), iron (Fe), potassium (K), magnesium (Mg), selenium (Se), and zinc (Zn). The results from athletes were compared to ones from the control group of adolescent non-athletes. Different minerals demonstrated sampling specific distribution. Sport type specificity of mineral content was found. These findings can help in the process of mineral status data standardization and in training process to correct the sport-associated mineral disbalances.

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Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

Cited by 9 publications

References 44 publications

Aluminum and aluminum oxide nanomaterials uptake after oral exposure - a comparative study

Aluminum and aluminum oxide nanomaterials uptake after oral exposure - a comparative study

Elemental metabolomics

Hair and Saliva Trace Elements Content in Young Athletes from Kazan Region, Russia

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