The effect of physical effort on retinal activity in the human eye: rod and cone flicker electroretinogram studies

Zwierko, Teresa; Czepita, Damian; Lubiński, Wojciech

doi:10.1007/s00417-010-1305-1

Cited by 13 publications

(6 citation statements)

References 37 publications

(51 reference statements)

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“…hormonal and cardiovascular), including the ocular physiology. 5 In this regard, there have been several ocular indices such as the neural conductivity in the visual pathway, 6 neuro-retinal activity, 7 tear osmolarity, 8 intraocular pressure (IOP), 9 and optic nerve and macular perfusion, 10 among others, that have revealed to be sensitive to physical effort. In the last years, due to the positive association between mean levels and peaks of IOP and the risk of glaucoma, 11 numerous researchers have focused on the short- and long-term effects of different types of physical exercise on IOP.…”

Section: Introductionmentioning

confidence: 99%

Effect of a maximal treadmill test on intraocular pressure and ocular perfusion pressure: The mediating role of fitness level

Vera

Jiménez

Redondo

et al. 2019

European Journal of Ophthalmology

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Objectives: We compared the impact of a maximal treadmill test on intraocular pressure and ocular perfusion pressure between trained and untrained individuals. Methods: Based on the maximal aerobic capacity (relative VO2 max), 31 military helicopter pilots were divided into groups of trained (n = 16; VO2 max = 57.06 ± 1.66) and untrained (n = 15; VO2 max = 43.42 ± 1.19) individuals. Intraocular pressure and blood pressure were collected before effort, just after volitional exhaustion and after 5 and 15 min of recovery. Results: The maximal treadmill test induced significant changes on intraocular pressure (p < 0.001, η2 = 0.52) and ocular perfusion pressure (p < 0.001, η2 = 0.60). Intraocular pressure and ocular perfusion pressure increased just after volitional exhaustion (effect size = 0.88 and 1.59, respectively), and these values returned to baseline levels after 5 (effect size = 0.87 and 1.26, respectively) and 15 (effect size = 1.23 and 1.91, respectively) min of recovery. The untrained group exhibited higher intraocular pressure and ocular perfusion pressure values in comparison with the trained group just after volitional exhaustion (effect size = 1.43 and 0.11 for intraocular pressure and effect size = 2.81 and 0.96 for ocular perfusion pressure). Five minutes of recovery was insufficient to reach baseline intraocular pressure and ocular perfusion pressure values only for the untrained group (effect size = 0.91 and 0.72, respectively). Conclusion: Our findings reveal that fitness level modulates the intraocular pressure and ocular perfusion pressure responses to a maximal treadmill test, being high fitness levels desirable in order to attenuate the impact of maximal efforts on these indices. These outcomes may be of clinical relevance for the management of glaucoma patients or those at risk, although future studies are needed to test these results in a clinical population.

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Section: Introductionmentioning

confidence: 99%

Effect of a maximal treadmill test on intraocular pressure and ocular perfusion pressure: The mediating role of fitness level

Vera

Jiménez

Redondo

et al. 2019

European Journal of Ophthalmology

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“…19–21), the optimal exercise intensity for benefit to retina is unstudied and unknown. Ocular blood flow increases with biking intensity in humans,22 and rod-mediated signaling decreases with greater exercise intensity, whereas cone-mediated signaling is unaffected 23. A variety of exercise regimens have been used in exercise studies, but the influence of varying exercise intensities on protection in retinal disease has not been systematically tested.…”

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confidence: 99%

Low-Intensity Exercise in Mice Is Sufficient to Protect Retinal Function During Light-Induced Retinal Degeneration

Mees

Coulter

Chrenek

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Purpose We previously reported that a specific treadmill running exercise regimen protects against light-induced retinal degeneration (LIRD) in mice. We hypothesized that this protective effect varies with running intensity. To test this, mice undergoing LIRD were run at different treadmill speeds and retinal function was assessed. Methods BALB/c mice were assigned to LIRD groups at varying treadmill speeds—0, 5, 10, or 20 m/min labeled inactive, low, medium, and high, respectively—and compared with naïve mice exposed to standard lighting (50 lux; naïve). Following 2 weeks of exercise, a subset of mice were exposed to toxic light (10,000 lux; LIRD) for 4 hours. After 5 additional days of exercise, retinal function was assessed by ERG. Corticosterone levels in serum and cathepsin B (CTSB) protein levels in muscle, brain, serum, and retina were measured. The retinal gene expression of complement factor 1qa ( C1qa ) and CTSB were measured. Results The low+LIRD and medium+LIRD exercise groups had greater a- and b-wave ERG amplitudes when compared with the inactive+LIRD group ( P < 0.02). The high+LIRD mice only differed from the inactive+LIRD mice in their dark-adapted b-waves. Serum corticosterone increased in the high+LIRD mice ( P < 0.006). Retinal CTSB protein levels were higher in the low+LIRD versus high+LIRD mice ( P < 0.004) but were otherwise unchanged. Exercise of any intensity decreased C1qa gene expression. Conclusions Faster running did not additionally protect against LIRD, but it did increase serum corticosterone, suggesting stress-induced limits to exercise benefits. Unexpectedly, exercise did not increase CTSB proteins levels in muscle or serum, suggesting that it may not mediate exercise effects. Our results have implications for the use of low-intensity exercise as a vision loss treatment.

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“…As highlighted above, a portable ERG device can provide low-cost, noninvasive, and rapidly and widely available biomarkers of ocular and systemic diseases within the framework of oculomics. It may also provide a surrogate for general health, as the level of physical fitness seems to have an impact on the changes of b-wave electroretinogram and P100 of visual evoked potentials [52,53].…”

Section: The Reteval As a Potential Source For Oculomics Biomarkersmentioning

confidence: 99%

The Use of the RETeval Portable Electroretinography Device for Low-Cost Screening: A Mini-Review

Saad,

Turgut,

Sommer

et al. 2024

Klin Monbl Augenheilkd

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Electroretinography (ERG) provides crucial insights into retinal function and the integrity of the visual pathways. However, ERG assessments classically require a complicated technical background with costly equipment. In addition, the placement of corneal or conjunctival electrodes is not always tolerated by the patients, which restricts the measurement for pediatric evaluations. In this short review, we give an overview of the use of the RETeval portable ERG device (LKC Technologies, Inc., Gaithersburg, MD, USA), a modern portable ERG device that can facilitate screening for diseases involving the retina and the optic nerve. We also review its potential to provide ocular biomarkers in systemic pathologies, such as Alzheimerʼs disease and central nervous system alterations, within the framework of oculomics.

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The effect of physical effort on retinal activity in the human eye: rod and cone flicker electroretinogram studies

Abstract: Rod-mediated responses were more susceptible to effort-induced homeostasis disruptions than the cone-mediated responses. The application of ERGs may be used as neurophysiological criteria in defining the cardiovascular status of the physical performance.

Cited by 13 publications

References 37 publications

Effect of a maximal treadmill test on intraocular pressure and ocular perfusion pressure: The mediating role of fitness level

Effect of a maximal treadmill test on intraocular pressure and ocular perfusion pressure: The mediating role of fitness level

Low-Intensity Exercise in Mice Is Sufficient to Protect Retinal Function During Light-Induced Retinal Degeneration

The Use of the RETeval Portable Electroretinography Device for Low-Cost Screening: A Mini-Review

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