The effect of physical conditioning on antipyrine clearance

Abstract

The eects of physical conditioning on antipyrine clearance were studied in two groups of subjects. Healthy men not engaged in the systematic practice of any sport were compared with endurance runners (de®ned as men running >80 km/week). Studies were carried out at three dierent periods of the annual plan training at 4-month intervals. Antipyrine was administered orally and pharmacokinetic parameters were obtained from saliva samples by the multiple-sample method. Endurance performance, expressed in terms of the maximal oxygen uptake ( O 2 max ), the ventilatory threshold and the 4-mM á l A1 lactate threshold (OBLA), was higher in trained than in control subjects at each of the three periods. Antipyrine clearance was also signi®-cantly elevated and antipyrine half-life reduced in runners during all periods. No signi®cant dierence in O 2 max or antipyrine clearance was found between the various periods in either trained or control subjects. Both ventilatory threshold and OBLA increased significantly along the training period in conditioned subjects. Signi®cant correlations were found between antipyrine clearance and O 2 max , ventilatory threshold and OBLA. In summary, these results indicate an association between aerobic conditioning and increased hepatic oxidative metabolism of low-clearance drugs.

Physical exercise and improvement of liver oxidative metabolism in the elderly

“…The eects of physical exercise on liver oxidative metabolism are sometimes unclear due to lack of control of environmental factors, or to the use of inappropriate experimental designs and kinetic models (Boel et al 1984;De Vito et al 1995;Fabbri et al 1991;Frenkl et al 1980;Oriolli et al 1990). However, we have recently reported the existence of an association between aerobic conditioning and antipyrine clearance that suggests an increased hepatic oxidative metabolism of low-clearance drugs (Villa et al 1998). Participation in regular exercise programs could thus be proposed as an eective intervention to reduce or prevent the decline of drug metabolism capacity in the elderly.…”

Expression Profiles of Cytochrome P450s Following Swimming Exercise in Aging Rats

“…Other studies have reported that swimming exercise increases antipyrine clearance by excretion. 31,32 It was previously reported that CYP450 27B1, which metabolizes vitamin D, was significantly up-regulated between 1 and 3 hours after the end of exercise. Resistance exercises that improve vitamin D metabolism in skeletal muscle increased the levels of CYP450 27B1.…”

“…6 Additionally, sprinters and long-distance runners show significantly increased antipyrine clearance than sedentary subjects. 31,36 Maximal exercise has been shown to alter the activity of GH, IGF-1, and CYP1A2. High-intensity exercise in young ice hockey players increased the GH concentration, with a concomitant increase in CYP1A2 mRNA levels.…”

“…18 CYP levels were also found to be increased in rats after 14 days of exercise compared with that in sedentary rats. 19,20 Similarly, physical activity in elderly individuals shows beneficial effects on oxidative metabolism in the liver, 21 and regular exercise contributes to the health of aged humans. Additionally, aerobic exercise activity increases the hepatic oxidative metabolism of low-clearance drugs.…”

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“…Measuring of antipyrine clearance (plasma or saliva) makes it possible to explain interindividual and intra-individual variations drug response variations, which may be genetic 20 , secondary to a pathological situation 21 , a drug interaction 22 or related to exogenous factors, such as diet 23,24 , tobacco 25 , physical activity 26 and exposure to chemical substances 27 .…”